公开(公告)号：EP3536345A1

公开(公告)日：2019-09-11

申请号：EP19169083.3

申请日：2015-05-06

申请人： The Johns Hopkins University ,  Northwestern University

发明人： RAY, Sangeeta ,  POMPER, Martin G. ,  MEADE, Thomas J. ,  MEASE, Ronnie C ,  CHEN, Ying ,  YANG, Xing ,  ROTZ, Matthew

IPC分类号： A61K51/04 ,  A61K49/00 ,  A61K49/10 ,  A61P35/00 ,  A61K49/12 ,  A61K51/06 ,  C07D257/02 ,  C07D403/14 ,  A61K103/00 ,  A61K103/20 ,  A61K103/30 ,  A61K103/32

摘要： Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T 1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86 Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.

公开(公告)号：EP3964498A1

公开(公告)日：2022-03-09

申请号：EP21198593.2

申请日：2010-03-19

申请人： The Johns Hopkins University

发明人： POMPER, Martin G ,  MEASE, Ronnie C ,  RAY, Sangeeta ,  CHEN, Ying

IPC分类号： C07D209/10 ,  C07D311/82 ,  A61K31/352 ,  A61K49/00 ,  A61P35/00

摘要： Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.

公开(公告)号：EP3524277A1

公开(公告)日：2019-08-14

申请号：EP19163516.8

申请日：2012-11-30

申请人： The Johns Hopkins University

发明人： POMPER, Martin Gilbert ,  RAY, Sangeeta ,  MEASE, Ronnie C ,  SHALLAL, Hassan

IPC分类号： A61K51/08 ,  C07K5/02

摘要： The present invention provides a compound contains a PSMA binding Lys-Glu urea moiety linked to DOTA in complex with 111 In 3+ and its use in imaging PSMA cells.