公开(公告)号：EP3313182A1

公开(公告)日：2018-05-02

申请号：EP16800686.4

申请日：2016-05-26

申请人： The Regents of The University of Michigan

发明人： SHERMAN, David, H. ,  YU, Fengan ,  XI, Chuanwu ,  WU, Jianfeng ,  SCHULTZ, Pam ,  TRIPATHI, Ashootosh ,  PARK, Sung, Ryeol

IPC分类号： A01N25/00

CPC分类号： C07K7/06 ,  A01N37/46 ,  A01N43/76 ,  A61K38/07 ,  A61K45/06 ,  C07D413/12 ,  C07K5/00 ,  C07K5/081 ,  C07K5/1013 ,  C07K14/195 ,  C12N9/88 ,  C12Y402/99021 ,  Y02A50/473

摘要： Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm inhibitors, cahuitamycins. Also provided are mutant S. gandocaensis, methods of inhibiting biofilm formation, methods of producing, or increasing the production of, cahuitamycins, methods for synthesizing cahuitamycins, and methods of purifying cahuitamycins.