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公开(公告)号：EP2929046B1
公开(公告)日：2019-03-20
申请号：EP13863036.3
申请日：2013-12-10
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公开(公告)号：EP3561068A1
公开(公告)日：2019-10-30
申请号：EP19160104.6
申请日：2013-12-10
发明人： MATJE, Douglas , PATEL, Paul , HOLMES, Elizabeth , GIBBONS, Ian
摘要： Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed. Assays may be performed in a single reaction mixture, allowing more accurate and precise cholesterol determinations, including ratios of cholesterol sub-fractions to total cholesterol, at less expense, than would be expected by performing several different assays in different reaction mixtures.
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公开(公告)号：EP3456358A1
公开(公告)日：2019-03-20
申请号：EP18197488.2
申请日：2007-05-10
发明人： HOLMES, Elizabeth A , GIBBONS, Ian
IPC分类号： A61K49/00 , A61K39/00 , G01N33/543 , G01N33/569 , B01L3/00 , C12Q1/70
摘要： The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection in a sample of bodily fluid.
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