公开(公告)号：EP2183253A1

公开(公告)日：2010-05-12

申请号：EP08775964.3

申请日：2008-07-16

申请人： UCB Pharma, S.A.

发明人： JOHNSON, James Andrew ,  BROOKINGS, Daniel Christopher ,  HUTCHINGS, Martin Clive ,  LANGHAM, Barry John ,  NEUSS, Judi Charlotte

IPC分类号： C07D495/04 ,  A61K31/4365

CPC分类号： C07D495/04

摘要： A series of thieno[2,3-b]pyridine derivatives which are substituted in the 2- position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment, of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.

公开(公告)号：EP2099805A2

公开(公告)日：2009-09-16

申请号：EP07846789.1

申请日：2007-11-23

申请人： UCB Pharma S.A.

发明人： DAVIS, Jeremy Martin ,  BROOKINGS, Daniel Christopher ,  LANGHAM, Barry, John ,  HUTCHINGS, Martin, Clive

IPC分类号： C07D495/04 ,  A61K31/4365 ,  A61P29/00

CPC分类号： C07D495/04

摘要： The present invention concerns novel 3-aminothienopyridinone derivatives of the formula I, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

公开(公告)号：EP2029570A1

公开(公告)日：2009-03-04

申请号：EP07733067.8

申请日：2007-06-04

申请人： UCB Pharma S.A.

发明人： ALEXANDER, Rikki Peter ,  BAILEY, Stuart ,  BRAND, Stephen ,  BROOKINGS, Daniel Christopher ,  BROWN, Julien Alistair ,  HAUGHAN, Alan Findlay ,  KINSELLA, Natasha ,  LOWE, Christopher ,  MACK, Stephen Robert ,  PITT, William Ross ,  RICHARD, Marianna Dilani ,  SHARPE, Andrew ,  TAIT, Laura Jane

IPC分类号： C07D333/66

CPC分类号： C07D333/66 ,  C07D333/68 ,  C07D333/76 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D451/04 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： A series of 5,6-dihydro-1-benzothiophen-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

公开(公告)号：EP2029570B1

公开(公告)日：2014-10-15

申请号：EP07733067.8

申请日：2007-06-04

申请人： UCB Pharma S.A.

发明人： ALEXANDER, Rikki Peter ,  BAILEY, Stuart ,  BRAND, Stephen ,  BROOKINGS, Daniel Christopher ,  BROWN, Julien Alistair ,  HAUGHAN, Alan Findlay ,  KINSELLA, Natasha ,  LOWE, Christopher ,  MACK, Stephen Robert ,  PITT, William Ross ,  RICHARD, Marianna Dilani ,  SHARPE, Andrew ,  TAIT, Laura Jane

IPC分类号： C07D333/66

CPC分类号： C07D333/66 ,  C07D333/68 ,  C07D333/76 ,  C07D409/04 ,  C07D409/06 ,  C07D409/10 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D451/04 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

公开(公告)号：EP2614061B1

公开(公告)日：2015-05-20

申请号：EP11755423.8

申请日：2011-09-02

申请人： UCB Pharma, S.A.

发明人： PARTON, Andrew Harry ,  ALI, Mezher Hussein ,  BROOKINGS, Daniel Christopher ,  BROWN, Julien Alistair ,  FORD, Daniel James ,  FRANKLIN, Richard Jeremy ,  LANGHAM, Barry John ,  NEUSS, Judi Charlotte ,  QUINCEY, Joanna Rachel

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00

CPC分类号： C07D471/04 ,  A61K31/519

公开(公告)号：EP2744812A2

公开(公告)日：2014-06-25

申请号：EP12753225.7

申请日：2012-08-15

申请人： UCB Pharma, S.A. ,  Katholieke Universiteit Leuven, K.U. Leuven R&D

发明人： BROOKINGS, Daniel Christopher ,  FORD, Daniel James ,  GHAWALKAR, Anant Ramrao ,  HERMAN, Jean ,  HUANG, Qiuya ,  KULISA, Claire Louise ,  LOUAT, Thierry ,  NEUSS, Judi Charlotte ,  REUBERSON, James Thomas ,  VANDERHOYDONCK, Bart

IPC分类号： C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  A61K31/519 ,  A61P29/00

CPC分类号： C07D495/04 ,  A61K31/519 ,  C07D513/04 ,  C07D519/00

摘要： A series of monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.

公开(公告)号：EP2614061A1

公开(公告)日：2013-07-17

申请号：EP11755423.8

申请日：2011-09-02

申请人： UCB Pharma, S.A.

发明人： PARTON, Andrew Harry ,  ALI, Mezher Hussein ,  BROOKINGS, Daniel Christopher ,  BROWN, Julien Alistair ,  FORD, Daniel James ,  FRANKLIN, Richard Jeremy ,  LANGHAM, Barry John ,  NEUSS, Judi Charlotte ,  QUINCEY, Joanna Rachel

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00

CPC分类号： C07D471/04 ,  A61K31/519

摘要： A series of quinoline and quinoxaline derivatives comprising a fluorinated ethyl side-chain, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

公开(公告)号：EP2776445A1

公开(公告)日：2014-09-17

申请号：EP12801466.9

申请日：2012-11-08

申请人： UCB Pharma, S.A. ,  Katholieke Universiteit Leuven K.U. Leuven R&D

发明人： BROOKINGS, Daniel Christopher ,  FORD, Daniel James ,  FRANKLIN, Richard Jeremy ,  GHAWALKAR, Anant Ramrao ,  KULISA, Claire Louise ,  NEUSS, Judi Charlotte ,  REUBERSON, James Thomas

IPC分类号： C07D513/04 ,  A61K31/519 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D513/04 ,  A61K31/519 ,  C07D519/00

摘要： A series of thiazolo[5,4-
d ]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.

公开(公告)号：EP2183253B1

公开(公告)日：2013-12-18

申请号：EP08775964.3

申请日：2008-07-16

申请人： UCB Pharma, S.A.

发明人： JOHNSON, James Andrew ,  BROOKINGS, Daniel Christopher ,  HUTCHINGS, Martin Clive ,  LANGHAM, Barry John ,  NEUSS, Judi Charlotte

IPC分类号： C07D495/04 ,  A61K31/4365

CPC分类号： C07D495/04

摘要： A series of thieno[2,3-b]pyridine derivatives which are substituted in the 2-position by a substituted anilino moiety, being selective inhibitors of human MEK (MAPKK) enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.

公开(公告)号：EP2240494A1

公开(公告)日：2010-10-20

申请号：EP09703360.9

申请日：2009-01-20

申请人： UCB Pharma, S.A.

发明人： BROOKINGS, Daniel Christopher ,  HUTCHINGS, Martin Clive ,  LANGHAM, Barry John

IPC分类号： C07D495/04 ,  C07D519/00

CPC分类号： C07D495/04 ,  C07D519/00

摘要： The invention provides a series of thieno[2,3-b]pyridine derivatives wherein Y represents a linkage of formula C(O) or S(O)2; R1 represents hydrogen, halogen, cyano, nitro, C|-6 alkyl, trifluoromethyl, Ci.6 alkoxy, trifluoromethoxy, C1-6 alkylthio, C1-6 alkylsulphinyl or C1-6 alkylsulphonyl; R2 represents halogen, nitro, cyano, C1-6 alkyl, C2-6 alkynyl, hydroxy(C1-6)alkyl or formyl; and R3 represents a group of formula (a), (b), (c), (d) or (e): wherein the asterisk (*) represents the point of attachment to the remainder of the molecule. The compounds of formula (I) are selective inhibitors of human MEK (MAPICIC) enzymes and are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, proliferative (including oncological) and nociceptive conditions.