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公开(公告)号：EP2776445A1
公开(公告)日：2014-09-17
申请号：EP12801466.9
申请日：2012-11-08
发明人： BROOKINGS, Daniel Christopher , FORD, Daniel James , FRANKLIN, Richard Jeremy , GHAWALKAR, Anant Ramrao , KULISA, Claire Louise , NEUSS, Judi Charlotte , REUBERSON, James Thomas
IPC分类号： C07D513/04 , A61K31/519 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00
CPC分类号： C07D513/04 , A61K31/519 , C07D519/00
摘要： A series of thiazolo[5,4-
d ]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.-
公开(公告)号：EP2614061B1
公开(公告)日：2015-05-20
申请号：EP11755423.8
申请日：2011-09-02
申请人： UCB Pharma, S.A.
发明人： PARTON, Andrew Harry , ALI, Mezher Hussein , BROOKINGS, Daniel Christopher , BROWN, Julien Alistair , FORD, Daniel James , FRANKLIN, Richard Jeremy , LANGHAM, Barry John , NEUSS, Judi Charlotte , QUINCEY, Joanna Rachel
IPC分类号： C07D471/04 , A61K31/519 , A61P9/00 , A61P25/28 , A61P29/00
CPC分类号： C07D471/04 , A61K31/519
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公开(公告)号：EP2744812A2
公开(公告)日：2014-06-25
申请号：EP12753225.7
申请日：2012-08-15
发明人： BROOKINGS, Daniel Christopher , FORD, Daniel James , GHAWALKAR, Anant Ramrao , HERMAN, Jean , HUANG, Qiuya , KULISA, Claire Louise , LOUAT, Thierry , NEUSS, Judi Charlotte , REUBERSON, James Thomas , VANDERHOYDONCK, Bart
IPC分类号： C07D495/04 , C07D513/04 , C07D519/00 , A61K31/519 , A61P29/00
CPC分类号： C07D495/04 , A61K31/519 , C07D513/04 , C07D519/00
摘要： A series of monocyclic or bicyclic diamine-substituted thieno[2,3-d]pyrimidine and isothiazolo[5,4-d]pyrimidine derivatives are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
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公开(公告)号：EP2614061A1
公开(公告)日：2013-07-17
申请号：EP11755423.8
申请日：2011-09-02
申请人： UCB Pharma, S.A.
发明人： PARTON, Andrew Harry , ALI, Mezher Hussein , BROOKINGS, Daniel Christopher , BROWN, Julien Alistair , FORD, Daniel James , FRANKLIN, Richard Jeremy , LANGHAM, Barry John , NEUSS, Judi Charlotte , QUINCEY, Joanna Rachel
IPC分类号： C07D471/04 , A61K31/519 , A61P9/00 , A61P25/28 , A61P29/00
CPC分类号： C07D471/04 , A61K31/519
摘要： A series of quinoline and quinoxaline derivatives comprising a fluorinated ethyl side-chain, being selective inhibitors of P13 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
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