公开(公告)号：EP3256139A4

公开(公告)日：2018-07-18

申请号：EP16750009

申请日：2016-02-12

申请人： UNIV PENNSYLVANIA

发明人： KOO HYUN ,  GAO LIZENG ,  CORMODE DAVID ,  NAHA PRATAP

IPC分类号： A61K9/51 ,  A01N59/16 ,  A01P1/00 ,  A61K33/26

CPC分类号： A61K8/19 ,  A01N59/16 ,  A61K8/0245 ,  A61K8/20 ,  A61K8/22 ,  A61K8/66 ,  A61K8/73 ,  A61K9/006 ,  A61K9/0063 ,  A61K9/14 ,  A61K9/5161 ,  A61K33/26 ,  A61K33/40 ,  A61K47/6923 ,  A61K2800/413 ,  A61K2800/624 ,  A61K2800/92 ,  A61Q11/00 ,  Y02A50/471 ,  Y02A50/473 ,  A61K2300/00 ,  A01N25/12 ,  A01N25/26 ,  A01N59/00 ,  A01N59/06 ,  A01N59/10 ,  A01N59/20 ,  A01N59/26

摘要： The presently disclosed subject matter relates to iron oxide nanoparticle compositions and formulations thereof for: (1) the treatment and elimination of biofilms; (2) the prevention of biofilm formation; (3) biofilm extracellular matrix degradation; (4) the inhibition of bacterial viability and growth within the biofilm; and (5) the prevention of tooth or apatitic demineralization. In particular, the presently disclosed subject matter provides a composition for the prevention and treatment of an oral disease (e.g., dental caries) that includes one or more iron oxide nanoparticles and hydrogen peroxide.