公开(公告)号：EP2648718A4

公开(公告)日：2016-01-06

申请号：EP11846156

申请日：2011-12-09

申请人： UNIV RUTGERS

发明人： LIN SHELDON SUTON ,  PAGLIA DAVID NAISBY ,  O'CONNOR JOHN PATRICK ,  BREITBART ERIC ,  BENEVENIA JOSEPH

IPC分类号： A61K31/28 ,  A61K47/04 ,  A61L27/54 ,  A61L31/16

CPC分类号： A61L31/08 ,  A61K9/0024 ,  A61K9/0092 ,  A61K31/28 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/40 ,  A61L2420/04 ,  A61L2430/02

摘要： The present invention discloses vanadium-based insulin-mimetic agent composite coatings, application of these coatings onto implantable devices, and use of the implantable devices for accelerating osseous healing. The invention also encompasses methods of manufacturing implantable devices coated with vanadium-based insulin-mimetic agent composite coatings and the implantable devices so manufactured. The implantable devices have wide applications, including but not limited to treating bone fracture, bone trauma, arthrodesis, and other bone deficit conditions, as well as bone injuries incurred in military and sports activities.

摘要翻译： 本发明公开了基于钒的胰岛素模拟剂复合涂层，将这些涂层应用于可植入装置，以及使用可植入装置来加速骨愈合。 本发明还包括制造涂覆有基于钒的胰岛素模拟剂复合涂层的可植入装置和如此制造的可植入装置的方法。 可植入装置具有广泛的应用，包括但不限于治疗骨折，骨创伤，关节固定术和其他骨缺损状况，以及在军事和体育活动中引起的骨损伤。

公开(公告)号：EP2911614A4

公开(公告)日：2016-04-13

申请号：EP13849022

申请日：2013-10-25

申请人： UNIV RUTGERS

发明人： LIN SHELDON SUTON ,  KOERNER JOHN ,  VIVES MICHAEL J ,  BENEVENIA JOSEPH ,  BREITBART ERIC

IPC分类号： A61L27/54 ,  A61F2/30 ,  A61F2/44 ,  A61K33/04 ,  A61K33/24 ,  A61K33/30 ,  A61K35/32 ,  A61K45/06 ,  A61K47/46 ,  A61L27/30

CPC分类号： A61K33/30 ,  A61F2/4455 ,  A61F2002/30677 ,  A61F2310/00179 ,  A61F2310/00293 ,  A61F2310/00359 ,  A61F2310/0097 ,  A61K33/04 ,  A61K33/24 ,  A61K35/32 ,  A61K47/46 ,  A61L27/306 ,  A61L27/54 ,  A61L2300/102 ,  A61L2430/38

摘要： Bone tissue materials comprising insulin-mimetic agents, such as suitable zinc, vanadium, tungsten, molybdenum, niobium, selenium, and manganese compounds, for facilitating spinal fusion of vertebrae in spinal fusion surgical procedures, and methods thereof. Additionally provided is a bone tissue kit for facilitating fusion of vertebrae in a spinal fusion surgical procedure including a composition formulated for facile application in a spinal fusion procedure comprising an insulin-mimetic agent and a pharmaceutically acceptable carrier. Yet further provided is an implantable device for enhancing spinal fusion including a prosthetic implant configured to stabilize and promote the fusion of two adjacent vertebrae, wherein the bone tissue contacting surfaces of the prosthetic implant are coated with a composition comprising an insulin-mimetic agent.

公开(公告)号：EP2785358A4

公开(公告)日：2015-10-21

申请号：EP12853488

申请日：2012-11-29

申请人： UNIV RUTGERS

发明人： LIN SHELDON SUTON ,  PAGLIA DAVID NAISBY ,  O'CONNOR JAMES PATRICK ,  BENEVENIA JOSEPH ,  WEY AARON ,  SUBRAMANIAN SANGEETA ,  CHIRICHELLA PAUL ,  VIVES MICHAEL J ,  KOERNER JOHN D

IPC分类号： A61K33/24 ,  A61K9/00 ,  A61K33/30 ,  A61K33/32 ,  A61K35/32 ,  A61K38/17 ,  A61K38/18 ,  A61K38/20 ,  A61K38/29 ,  A61K45/06 ,  A61L27/54

CPC分类号： A61K33/24 ,  A61K9/0024 ,  A61K33/04 ,  A61K33/30 ,  A61K33/32 ,  A61K35/32 ,  A61K38/179 ,  A61K38/1793 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/1875 ,  A61K38/2026 ,  A61K38/2066 ,  A61K38/2086 ,  A61K38/29 ,  A61K45/06 ,  A61L27/54 ,  A61L2430/38 ,  A61K2300/00

摘要： Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic agents or compositions thereof to patients in need of such treatment are also disclosed.

摘要翻译： 公开了通过局部给予有需要的患者的胰岛素模拟物促进骨愈合或再生的方法以及用于加速骨愈合过程的胰岛素模拟化合物的新用途。 还公开了骨损伤治疗和适用于局部给予需要这种治疗的患者胰岛素模拟剂或其组合物的空隙填充装置，产品和试剂盒。