公开(公告)号：EP3373990A1

公开(公告)日：2018-09-19

申请号：EP16805611.7

申请日：2016-11-10

申请人： The General Hospital Corporation

发明人： ORAL, Ebru ,  SUHARDI, Jeremy V. ,  MURATOGLU, Orhun K. ,  MALCHAU, Henrik ,  RUBASH, Harry E. ,  FREIBERG, Andrew A.

IPC分类号： A61L27/16 ,  A61L27/54

CPC分类号： A61L27/54 ,  A61F2/34 ,  A61F2/389 ,  A61F2/4081 ,  A61F2002/30677 ,  A61F2002/30971 ,  A61L27/04 ,  A61L27/16 ,  A61L27/26 ,  A61L2300/406 ,  A61L2300/428 ,  A61L2300/608 ,  A61L2300/61 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2420/06 ,  A61L2420/08 ,  A61L2430/24 ,  C08L23/06

摘要： Therapeutic polymeric materials, therapeutic polymeric materials containing medical implants and methods for making the same, and related materials are described. Methods of making medical implants containing additives antibiotics, therapeutic polymers, and materials used therewith also are described. Methods of spatially controlling additive/antibiotic concentrations, non-homogenous distribution of therapeutic agents in polymeric materials and therapeutic medical implants containing layered constructs of polymeric materials are provided. Therapeutic medical implants containing incorporated therapeutic agents in the polymeric materials, for example, antibiotics into polymeric total joint implants, are useful for delivery of the therapeutic agents into the surrounding mediums.

公开(公告)号：EP3328452A1

公开(公告)日：2018-06-06

申请号：EP16750671.6

申请日：2016-07-28

申请人： CeramTec GmbH

发明人： PORPORATI, Alessandro, Alan ,  RASCHKE, Marita ,  STREICHER,Robert ,  KUNTZ, Meinhard ,  PREUSS, Roman ,  GOTTWIK, Lukas

IPC分类号： A61L27/10 ,  A61L27/30 ,  A61L27/50

CPC分类号： A61L27/306 ,  A61L27/10 ,  A61L27/50 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2420/08 ,  A61L2430/02

摘要： The present invention relates to metallic and/or ceramic components, in particular in the field of medical technology, having improved osseointegrative and osteoinductive properties. The present invention also relates to a method for producing the ceramic components.

公开(公告)号：EP3251633A1

公开(公告)日：2017-12-06

申请号：EP17176541.5

申请日：2012-06-01

申请人： W.L. Gore & Associates Inc.

发明人： BRUCHMAN, William, C. ,  HARTMAN, Cody, L.

IPC分类号： A61F2/24

CPC分类号： A61F2/2403 ,  A61F2/24 ,  A61F2/2415 ,  A61F2210/0076 ,  A61F2230/00 ,  A61F2240/001 ,  A61F2240/005 ,  A61L27/34 ,  A61L27/48 ,  A61L27/507 ,  A61L27/56 ,  A61L2420/04 ,  A61L2420/08 ,  A61L2430/20 ,  Y10T29/49412 ,  C08L27/18

摘要： A thin, biocompatible, high-strength, composite material is disclosed that is suitable for use in various implanted configurations. The composite material maintains flexibility in high-cycle flexural applications, making it particularly applicable to high-flex implants such as heart pacing lead or heart valve leaflet. The composite material includes at least one porous expanded fluoropolymer layer and an elastomeric material substantially filling substantially all of the pores of the porous expanded fluoropolymer.

摘要翻译： 公开了一种适用于各种植入结构的薄的生物相容性高强度复合材料。 该复合材料在高循环弯曲应用中保持灵活性，使其特别适用于高柔性植入物，如心脏起搏铅或心脏瓣膜小叶。 复合材料包括至少一个多孔膨胀含氟聚合物层和基本上充满多孔膨胀含氟聚合物的所有孔的弹性体材料。

公开(公告)号：EP2967824A4

公开(公告)日：2016-11-23

申请号：EP14779096

申请日：2014-03-12

申请人： UNIV CARNEGIE MELLON

发明人： BETTINGER CHRISTOPHER J ,  HOROWITZ MICHAEL BRUCE

IPC分类号： A61L31/10 ,  A61B17/12 ,  A61L29/08 ,  A61L29/16 ,  A61L31/16

CPC分类号： A61L29/085 ,  A61B17/12031 ,  A61B17/12113 ,  A61B17/12145 ,  A61B17/1215 ,  A61K31/352 ,  A61L29/148 ,  A61L29/16 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2420/04 ,  A61L2420/08 ,  A61L2430/36 ,  A61M25/0045 ,  C08L67/04

摘要： A method is described herein for the treatment of intracranial aneurysms. The method comprises inserting into an aneurysm an embolism coil coated with a polymeric coating comprising a genipin, such as genipin or a derivative thereof, thereby increasing the stability of clots within the aneurysm. According to one example, the coating is a poly(L-lactide-co-glycolide) (PLGA) is used to release genipin to crosslink fibrin clots thereby creating more stable occlusions. Increased clotting can improve segregation of the weakened portion of the blood vessel from the rest of the vasculature and reduce the risk of recurrence.

公开(公告)号：EP2897656B1

公开(公告)日：2016-11-02

申请号：EP13766000.7

申请日：2013-09-18

申请人： Corticalis AS

发明人： LYNGSTADAAS, Petter, S. ,  HAUGEN, Håvard, J. ,  TIAINEN, Hanna

IPC分类号： A61L27/06 ,  A61L27/10 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56

CPC分类号： A61L27/34 ,  A61L27/06 ,  A61L27/10 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/425 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/25 ,  A61L2300/412 ,  A61L2300/422 ,  A61L2300/64 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2420/06 ,  A61L2430/02 ,  A61L2430/12

摘要： The present document is directed to a titanium dioxide scaffold comprising a hydrogel coating comprising a biologically active substance. Also disclosed is a method for producing a thin hydrogel coating on a titanium dioxide scaffold and uses of the hydrogel coated scaffolds as medical implants.

公开(公告)号：EP2968661A1

公开(公告)日：2016-01-20

申请号：EP13877867.5

申请日：2013-07-22

申请人： Board of Trustees of the University of Arkansas

发明人： BIRIS, Alexandru, S.

IPC分类号： A61L27/14 ,  C08L101/16 ,  A61F2/28

CPC分类号： A61L27/54 ,  A61F2/28 ,  A61F2002/30224 ,  A61F2002/30971 ,  A61L27/34 ,  A61L27/446 ,  A61L27/46 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2420/04 ,  A61L2420/08 ,  A61L2430/02 ,  A61L2430/12 ,  Y10T156/1075

摘要： A method for producing a polymer film includes: obtaining a load graph representing a functional relationship between a weight percentage of tissue forming nanoparticles in a polymer film and a maximum load of that polymer film; obtaining a stress graph representing a functional relationship between the weight percentage of tissue forming nanoparticles in a polymer film and maximum stress of that polymer film; determining a first weight percentage corresponding to a peak of the load graph and determining a second weight percentage corresponding to a peak of the stress graph; determining an optimal weight percentage based on the first and second weight percentage values; and producing a polymer film having tissue forming nanoparticles at the optimal weight percentage.

公开(公告)号：EP2648718A4

公开(公告)日：2016-01-06

申请号：EP11846156

申请日：2011-12-09

申请人： UNIV RUTGERS

发明人： LIN SHELDON SUTON ,  PAGLIA DAVID NAISBY ,  O'CONNOR JOHN PATRICK ,  BREITBART ERIC ,  BENEVENIA JOSEPH

IPC分类号： A61K31/28 ,  A61K47/04 ,  A61L27/54 ,  A61L31/16

CPC分类号： A61L31/08 ,  A61K9/0024 ,  A61K9/0092 ,  A61K31/28 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/40 ,  A61L2420/04 ,  A61L2430/02

摘要： The present invention discloses vanadium-based insulin-mimetic agent composite coatings, application of these coatings onto implantable devices, and use of the implantable devices for accelerating osseous healing. The invention also encompasses methods of manufacturing implantable devices coated with vanadium-based insulin-mimetic agent composite coatings and the implantable devices so manufactured. The implantable devices have wide applications, including but not limited to treating bone fracture, bone trauma, arthrodesis, and other bone deficit conditions, as well as bone injuries incurred in military and sports activities.

摘要翻译： 本发明公开了基于钒的胰岛素模拟剂复合涂层，将这些涂层应用于可植入装置，以及使用可植入装置来加速骨愈合。 本发明还包括制造涂覆有基于钒的胰岛素模拟剂复合涂层的可植入装置和如此制造的可植入装置的方法。 可植入装置具有广泛的应用，包括但不限于治疗骨折，骨创伤，关节固定术和其他骨缺损状况，以及在军事和体育活动中引起的骨损伤。

公开(公告)号：EP2839849A4

公开(公告)日：2015-11-18

申请号：EP13778464

申请日：2013-04-19

申请人： NAT INST FOR MATERIALS SCIENCE ,  NAT UNIV CORP TOKYO MED & DENT

发明人： KIKUCHI MASANORI ,  TAKAKUDA KAZUO ,  MORIYAMA KEIJI ,  SUZUKI SHOICHI ,  UEZONO MASAYOSHI

IPC分类号： A61L27/46 ,  A61K6/00 ,  A61L27/04 ,  A61L27/06 ,  A61L27/28

CPC分类号： A61L27/46 ,  A61K6/0067 ,  A61K6/0085 ,  A61K6/033 ,  A61K6/04 ,  A61L27/04 ,  A61L27/06 ,  A61L27/12 ,  A61L27/24 ,  A61L27/28 ,  A61L27/32 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/112 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/45 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2420/06 ,  A61L2430/02 ,  C08L89/06

公开(公告)号：EP2531225A4

公开(公告)日：2015-11-11

申请号：EP11740446

申请日：2011-02-04

申请人： AMXTEK LLC

发明人： WALLS JAMES

IPC分类号： A61L27/02 ,  A61B17/60 ,  A61B17/86 ,  A61F2/02 ,  A61F2/44 ,  A61K9/70 ,  A61K33/38 ,  A61K33/42 ,  A61L24/00 ,  A61L27/38 ,  A61L27/42 ,  A61L27/44 ,  A61L27/54 ,  A61L27/56 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16

CPC分类号： A61L31/086 ,  A61B17/60 ,  A61B17/8625 ,  A61B17/866 ,  A61F2/28 ,  A61F2/32 ,  A61F2/4455 ,  A61F2/4644 ,  A61F2002/30032 ,  A61F2002/30034 ,  A61F2002/30036 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2310/00329 ,  A61F2310/00359 ,  A61F2310/00928 ,  A61K9/70 ,  A61K33/38 ,  A61K33/42 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/0063 ,  A61L24/0068 ,  A61L24/0084 ,  A61L24/0089 ,  A61L27/10 ,  A61L27/425 ,  A61L27/427 ,  A61L27/446 ,  A61L31/022 ,  A61L31/082 ,  A61L31/123 ,  A61L31/124 ,  A61L31/127 ,  A61L31/128 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/04 ,  A61L2430/02 ,  A61L2430/10 ,  A61L2430/34

摘要： A method for controlling generation of biologically desirable voids in a composition placed in proximity to bone or other tissue in a patient by selecting at least one water-soluble inorganic material having a desired particle size and solubility, and mixing the water-soluble inorganic material with at least one poorly-water-soluble or biodegradable matrix material. The matrix material, after it is mixed with the water-soluble inorganic material, is placed into the patient in proximity to tissue so that the water-soluble inorganic material dissolves at a predetermined rate to generate biologically desirable voids in the matrix material into which bone or other tissue can then grow.

摘要翻译： 一种用于通过选择至少一种具有所需粒度和溶解度的水溶性无机材料，并将水溶性无机材料与 至少一种难溶于水或可生物降解的基质材料。 将基质材料与水溶性无机材料混合后，在组织附近放置在患者体内，使得水溶性无机材料以预定的速率溶解，以在基质材料中产生生物上希望的空隙 或其他组织然后可以生长。

公开(公告)号：EP2893901A1

公开(公告)日：2015-07-15

申请号：EP13834583.0

申请日：2013-09-06

申请人： Kabushiki Kaisya Advance

发明人： URAKABE, Nobuchika

IPC分类号： A61C8/00 ,  A61L27/00

CPC分类号： A61C8/0013 ,  A61C8/0015 ,  A61C8/0022 ,  A61C8/0048 ,  A61C13/0006 ,  A61L27/32 ,  A61L2420/04 ,  A61L2430/12

摘要： A dental implant including a columnar core member and a covering layer which is covered over at least part of the outer circumferential surface of the core member and which is comprised of recrystallized apatite-based ceramic, wherein the covering layer is comprised of a hydrothermal treated layer of a plasma spray-deposited covering which is formed by spraying a plasma of a composite containing at least two types of calcium phosphate-based compounds which differ in melting point at the outer circumferential surface of the core member based on the melting point of the low melting point calcium phosphate-based compound among the calcium phosphate-based compounds. This dental implant is provided with a strength enabling it to sufficiently withstand a chewing force over a long period of time and with a fast bondability and affinity with the gum and furthermore is excellent in extraction strength as well.

摘要翻译： 一种牙科植入物，其包括柱状芯部件和覆盖层，所述覆盖层覆盖在所述芯部件的外周表面的至少一部分上并且由重结晶的磷灰石基陶瓷组成，其中所述覆盖层由水热处理层 基于低熔点的熔点，通过喷涂含有至少两种不同熔点的磷酸钙基化合物的复合材料的等离子体而形成的等离子喷涂沉积覆盖物 基于磷酸钙的化合物中的磷酸钙基化合物。 该牙科植入物具有使其能够在长时间内充分耐受咀嚼力并且与胶的快速粘合性和亲和性的强度，并且还具有优异的提取强度。