专利检索 ap:("USV Limited") AND inv:"CHOTHE, Santosh, Sadashiv" 第 1 页

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发明公开
STABLE PHARMACEUTICAL COMPOSITIONS OF CLOPIDOGREL BISULFATE AND PROCESS OF PREPARATION THEREOF 审中-公开
标题翻译：硫酸氢氯吡格雷稳定的药物组合物确保两HERSTELLUNGSVEFAHREN

公开(公告)号：EP2155168A2

公开(公告)日：2010-02-24

申请号：EP08738409.5

申请日：2008-04-08

申请人： USV Limited

发明人： HEGDE, Deepak, Anant , CHOTHE, Santosh, Sadashiv , GHOGARI, Imran, Shakur , OMRAY, Ashok

IPC分类号： A61K9/20 , A61K9/28 , A61K31/4365

CPC分类号： A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2866 , A61K31/4365

摘要： The present invention discloses novel stable oral pharmaceutical compositions comprising the active ingredient Clopidogrel bisulfate and hydrophilic polymers along with pharmaceutically acceptable excipients. Particularly, the said Clopidogrel bisulfate is crystalline Form 1 and the composition additionally comprises of one or more chelating agents and antioxidants. Further the invention relates to a novel process for preparation of stable pharmaceutical compositions wherein the Clopidogrel bisulfate Form I is coated with a hydrophilic polymer thereby providing an increased physical and chemical stability to the composition.