公开(公告)号：EP2609099A2

公开(公告)日：2013-07-03

申请号：EP11768174.2

申请日：2011-08-26

申请人： USV Limited

发明人： SATHE, Dhananjay Govind ,  DAMLE, Subhash Vishwanath ,  AROTE, Nitin Dnyaneshwar ,  AMBRE, Rakesh Ramchandra ,  SAWANT, Kamlesh Digambar ,  NAIK, Tushar Anil

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： The present invention relates to an improved process for preparation of Sitagliptin or pharmaceutically acceptable salts thereof. The present invention further relates to novel polymorphs of Sitagliptin salts and process for preparation thereof.

摘要翻译： 本发明涉及一种改善西他列汀或其药学上可接受的盐的制备方法。 本发明还涉及西他列汀盐的新型多晶型物及其制备方法。

公开(公告)号：EP2364967A3

公开(公告)日：2012-02-22

申请号：EP10192579.0

申请日：2010-11-25

申请人： USV Limited

发明人： Sathe, Dhananjay Govind ,  Damle, Subhash Vishwanath ,  Sawant, Kamlesh Digambar ,  Gatne, Parag Sukumar ,  Naik, Tushar Anil

IPC分类号： C07C211/42 ,  C07C209/16 ,  A61P25/16 ,  A61K31/135

CPC分类号： C07C209/16 ,  C07B2200/07 ,  C07C69/24 ,  C07C211/42 ,  C07C2602/08

摘要： The present invention relates to an improved process for the preparation of Rasagiline or pharmaceutically acceptable salts thereof. The present invention also relates to Rasagiline salts, polymorphs thereof and process for preparation thereof.

公开(公告)号：EP2364967A8

公开(公告)日：2011-12-07

申请号：EP10192579.0

申请日：2010-11-25

申请人： USV Limited

发明人： Sathe, Dhananjay Govind ,  Damle, Subhash Vishwanath ,  Sawant, Kamlesh Digambar ,  Gatne, Parag Sukumar ,  Naik, Tushar Anil

IPC分类号： C07C211/42 ,  C07C209/16 ,  A61P25/16 ,  A61K31/135

CPC分类号： C07C209/16 ,  C07B2200/07 ,  C07C69/24 ,  C07C211/42 ,  C07C2602/08

摘要： The present invention relates to an improved process for the preparation of Rasagiline or pharmaceutically acceptable salts thereof. The present invention also relates to Rasagiline salts, polymorphs thereof and process for preparation thereof.

摘要翻译： 本发明涉及一种制备雷沙吉兰或其药学上可接受的盐的改进方法。 本发明还涉及雷沙吉兰盐，其多晶型物及其制备方法。

公开(公告)号：EP2364967A2

公开(公告)日：2011-09-14

申请号：EP10192579.0

申请日：2010-11-25

申请人： USV Limited

发明人： Sathe, Dhananjay Govind

IPC分类号： C07C211/42 ,  C07C209/16 ,  A61P25/16 ,  A61K31/135

CPC分类号： C07C209/16 ,  C07B2200/07 ,  C07C69/24 ,  C07C211/42 ,  C07C2602/08

摘要： The present invention relates to an improved process for the preparation of Rasagiline or pharmaceutically acceptable salts thereof. The present invention also relates to Rasagiline salts, polymorphs thereof and process for preparation thereof.

摘要翻译： 本发明涉及制备雷沙吉兰或其药学上可接受的盐的改进方法。 本发明还涉及雷沙吉兰盐，其多晶型物及其制备方法。

公开(公告)号：EP2173768A1

公开(公告)日：2010-04-14

申请号：EP07870535.7

申请日：2007-12-06

申请人： USV Limited

发明人： SANKARARAMAN, Uma ,  MAITI, Dipanwita ,  SANKARANKUTTY, Meera ,  SHEKHAWAT, Rakesh ,  KOPPARAPU, Narasimha, Kumar ,  ZAIDI, Gulnaz ,  RATHOD, Bipinchandra ,  THAKAR, Niren, Praful ,  THAKUR, Priti ,  CHUTKE, Anjali ,  MISHRA, Shrikant

IPC分类号： C07K14/635 ,  C07K1/36

CPC分类号： C07K14/635 ,  C07K2319/21 ,  C07K2319/35 ,  C07K2319/50 ,  C07K2319/61

摘要： The present invention discloses a process for the preparation of rhPTH (1-34) also known as teriparatide by construction of a novel nucleotide, as an NcoI.IXhoI fragemt as set forth in SEQ. ID. No.:l encoding a chimeric fusion protein as set forth in SEQ.ID. No.:2 comprising of a fusion partrner consisting of 41 amino acids belonging to Escherichia coli β-galactosidase (LacZ) gene, an endopeptidase cleavage site, rhPTH (1-34) gene fragment, cloning the said nucleotide in an expression vector under the control of T7 promoter, transforming Escherichia coli with the said vector and expressing the chimeric fusion protein in fed batch fermentation. The present invention further discloses a low feed rate lactose induction for optimized expression of rhPTH (1-34) in Escherichia coli. The present invention also discloses an unique, novel two step orthogonal purification process for rhPTH (1-34) comprising of cation exchange chromatography optionally followed by preparative chromatography selected from HIC or RP- HPLC to yield a target protein of ≥ 99% purity. The present invention discloses a simple, cost-effective, environmentally benign method of producing high purity rhPTH (1-34).

公开(公告)号：EP1945607A1

公开(公告)日：2008-07-23

申请号：EP05826478.9

申请日：2005-11-09

申请人： USV Limited

发明人： TARUR, Venkatasubramanian, Radhakrishnan ,  SATHE, Dhananjay, Govind ,  BHISE, Nandu, Baban ,  NAIDU, Avinash, Venkatraman ,  AHER, Umesh, Parashram ,  PATIL, Sachin, Shivaji

IPC分类号： C07C253/30 ,  C07C255/41

CPC分类号： C07C253/30 ,  C07C253/34 ,  C07C255/41

摘要： A process for the preparation of highly pure (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl) acrylamide (Entacapone). It comprises condensing3,4-dihydroxy-5-nitro benzaldehyde with N,N-diethyl cyano acetamide in an organic solvent in the presence of an organic base and an acid under reflux conditions followed by distilling off the solvent under vacuum and treating the residue with a lower aliphatic carboxylic acid at 40 - 8O0C. The resulting residue is extracted with a chlorinated solvent and the solvent is distilled off under vacuum. The resulting residue is extracted with an organic solvent to obtain crude N,N-diethyl-2-cyano-3-3,4-dihydroxy-5-nitrophenyl)acrylamide. The crude product N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl) acrylamide formed is treated with a mixture of organic alcohol and organic acid in the molar ratio of the crude product to organic alcohol 1:5 to 15 and crude product to organic acid 1:1 to 3 under reflux conditions.

公开(公告)号：EP1904033A2

公开(公告)日：2008-04-02

申请号：EP06762653.1

申请日：2006-07-17

申请人： ALFRED, E. TIEFENBACHER GMBH & CO. KG ,  USV Limited

发明人： SINGNURKAR, Prurushottam, S. ,  TEWARI, Prashant, Kumar ,  KORITKE, Claudia ,  STARK, Georg

IPC分类号： A61K9/16 ,  A61K31/64

CPC分类号： A61K9/2077 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2059 ,  A61K31/64

摘要： The invention relates to a method for producing solid oral pharmaceutical compositions containing glimepiride. The compositions produced according to the inventive method are characterized by a high stability.

公开(公告)号：EP1848720A1

公开(公告)日：2007-10-31

申请号：EP05747156.7

申请日：2005-02-15

申请人： USV LIMITED

发明人： TARUR, Venkatasubramanian, Radhakrishnan ,  SATHE, Dhananjay, Govind ,  SAWANT, Kamlesh, Digambar ,  MONDKAR, Harish, Kashinath ,  DESHPANDE, Manoj, Madhukarrao Indrayani Niwas ,  NAIK, Tushar, Anil

IPC分类号： C07D495/04

CPC分类号： C07D495/04

摘要： The present invention discloses a rapid resolution process of racemic clopidogrel base followed by conversion of the resolved (S) isomer to crystalline Clopidogrel bisulfate Form I. The invention also discloses novel racemization process of the unwanted (R) isomer of clopidogrel base. The invention further discloses an improved process for preparation of acid addition salts of clopidogrel.

公开(公告)号：EP1831219A2

公开(公告)日：2007-09-12

申请号：EP05850947.2

申请日：2005-12-23

申请人： USV LIMITED

发明人： TARUR, Venkatasubramanian Radhakrishnan, USV Limited ,  KADAM, Suresh Mahadev, USV Limited ,  JOSHI, Anil Purushottam, USV Limited ,  GAVHANE, Sachin Baban, USV Limited ,  SAWANT, Kamlesh, Digambar ,  SATHE, Dhananjay, Govind ,  NAIK, Tushar, Anil ,  WADHAWA, Gurmeet, Chandramohan, Swatantra Sainik

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： A process for preparation of Imiquimod comprising oxidation of 1-Isobutyl-1H-imidazo-[4,5-c]-quinoline (II) afforded 1-Isobutyl-1H- imidazo-[4,5-c]-quinoline-5-N-oxide(III) which is isolated in pure form as its hydrochloride salt (IV) followed by conversion to 4-chloro derivative(V) and conversion to corresponding 4-iodo derivative (VI) which is a novel intermediate. This novel intermediate is converted to imiquimod (VIII) and purified via its organic salt. The invention also relates to crystalline polymorphic forms of Imiquimod Maleate, Fumarate and Oxalate.

公开(公告)号：EP1706113A1

公开(公告)日：2006-10-04

申请号：EP04806731.8

申请日：2004-07-16

申请人： USV Limited

发明人： TARUR, Venkatasubramanian Radhakrishnan ,  SATHE, Dhananjay Govind ,  MONDKAR, Harish Kashinath ,  BHOPALKAR, Rajesh Ganpat ,  PATIL, Samadhan Daulat

IPC分类号： A61K31/4035 ,  C07D209/48 ,  C07D403/06 ,  C07D209/34 ,  A61K31/4045 ,  A61P25/16

CPC分类号： C07D209/48 ,  C07D209/34

摘要： The present invention discloses a novel process and novel intermediates for the Preparation of 4-[2-(di -n-propyl amino) ethyl]-1,3-dihydro-2H-indol-2-one, commonly known as Ropinirole (I) and pharmaceutical composition comprising the same. Further the present invention also discloses a method of treatment for cardiovascular disorders and Parkinson’s disease.