公开(公告)号：EP4000675A1

公开(公告)日：2022-05-25

申请号：EP20839750.5

申请日：2020-07-15

申请人： Universidade de São Paulo - USP ,  Universidade de Coimbra - UC

发明人： ZANGIROLAMI, Amanda Cristina ,  BLANCO, Kate Cristina ,  BAGNATO, Vanderlei Salvador ,  INADA, Natalia Mayumi ,  VINAGREIRO, Carolina dos Santos ,  DIAS, Lucas Danilo ,  MOREIRA, Luís Guilherme da Silva Arnaut ,  PEREIRA, Maria Miguéns

IPC分类号： A61M16/04 ,  A61L29/04 ,  A61L29/16 ,  A61K47/58 ,  A61K31/33 ,  A61K31/12

摘要： The present invention describes methods for obtaining functionalized polymeric surfaces (MPn-PSm) from polymers or copolymers with appropriate functionalizations (X), which can be a halogen of a leaving group, such as polyvinyl chloride (MP1) and (chloromethyl)polystyrene-Merrifield (MP2), and curcumin photosensitizers (PS1), meso-tetra (aryl)porphyrins, chlorins or bacteriochlorins halogenated and functionalized with nucleophilic groups (PS2), in particular including P2 of the type meso-imidazoyl-porphyrins, chlorins or bacteriochlorins (PS3). The structures of all the photosensitizers in the present application incorporate a functional group (Y), which is a OH, SH or NH 2 nucleophile. The application also describes the covalent bonding process of the photosensitizers PS1-PS3 to the functional polymeric materials MP1-MP2 by means of a nucleophilic substitution reaction to prepare the MPn-Psm products. The formed products prevent microbial proliferation, which can cause the serious infections that are one of the main causes of death in patients using these devices.