公开(公告)号：EP1082750B1

公开(公告)日：2005-11-09

申请号：EP00913934.6

申请日：2000-03-15

Applicant: Varian, Inc.

Inventor： WELLS, Gregory, J. ,  YEE, Peter, P. ,  RUPORT, Marvin, A. ,  HUSTON, Charles, K.

IPC: H01J49/14

CPC classification number: H01J49/147

Abstract: An ion source (108) for use with an ion trap mass spectrometer (120). The ion source includes an electron source which produces a stream of electrons. The electrons are injected into an ionization chamber by the action of a repeller plate (104) and electron lens (106). Inside the ionization chamber, the electrons interact with a gas-phase sample to produce sample ions through the electron ionization process, or with a reagent gas to form reagent ions as part of a chemical ionization process. The sample ions produced are extracted from the ionization chamber by the action of an ion repeller (112) and an ion lens (105). The potentials on the electron repeller and lens, and ion repeller and lens are controlled to direct the electron stream away from the ionization chamber or to direct the sample ion beam away from an ion trap at the appropriate times during measurement of the sample ions.

公开(公告)号：EP1082750A1

公开(公告)日：2001-03-14

申请号：EP00913934.6

申请日：2000-03-15

Applicant: Varian, Inc.

Inventor： WELLS, Gregory, J. ,  YEE, Peter, P. ,  RUPORT, Marvin, A. ,  HUSTON, Charles, K.

IPC: H01J49/14

CPC classification number: H01J49/147

Abstract: An ion source (108) for use with an ion trap mass spectrometer (120). The ion source includes an electron source which produces a stream of electrons. The electrons are injected into an ionization chamber by the action of a repeller plate (104) and electron lens (106). Inside the ionization chamber, the electrons interact with a gas-phase sample to produce sample ions through the electron ionization process, or with a reagent gas to form reagent ions as part of a chemical ionization process. The sample ions produced are extracted from the ionization chamber by the action of an ion repeller (112) and an ion lens (105). The potentials on the electron repeller and lens, and ion repeller and lens are controlled to direct the electron stream away from the ionization chamber or to direct the sample ion beam away from an ion trap at the appropriate times during measurement of the sample ions.

公开(公告)号：EP1118098B1

公开(公告)日：2004-11-24

申请号：EP99954672.4

申请日：1999-09-27

Applicant: Varian, Inc.

Inventor： WELLS, Gregory, J. ,  TONG, Roger, C. ,  YEE, Peter, P.

IPC: H01J49/04

CPC classification number: H01J49/165 ,  H01J49/0431

公开(公告)号：EP1117993A1

公开(公告)日：2001-07-25

申请号：EP99956493.3

申请日：1999-09-27

Applicant: Varian, Inc.

Inventor： WELLS, Gregory, J. ,  TONG, Roger, C. ,  YEE, Peter, P.

IPC: G01N30/72 ,  H01J49/04

CPC classification number: H01J49/165 ,  G01N30/7266 ,  H01J49/045

Abstract: An apparatus for producing gas-phase ions from a sample compound in a carrier liquid. The electrospray needle (or capillary) (100) of the present invention includes a central metal tube (102) which carries the liquid containing the sample compound. The central tube (102) is surrounded by a plurality of tubes (104) which transport a nebulizing gas. The nebulizing gas tubes are placed symmetrically around the outside of the liquid containing tube. The nebulizer of the present invention produces a symmetric, non-annular gas flow which has variations in pressure around the circumference of the central tube. The pressure variations of the nebulizing gas flow produce additional shear forces on the liquid emerging from the central tube. This assists in forming a uniform electrospray of droplets from the liquid at lower nebulizing gas flow rates, thereby reducing the disadvantageous effects of the higber gas flow rates used in the art. The symmetric arrangement of the nebulizing gas tube provides support for the central sample carrying tube, thereby reducing the alignment problems found in prior art devices, and enhancing uniformity of the electrospray.

公开(公告)号：EP1118097B1

公开(公告)日：2006-11-22

申请号：EP99954671.6

申请日：1999-09-27

Applicant: Varian, Inc.

Inventor： WELLS, Gregory, J. ,  TONG, Roger, C. ,  YEE, Peter, P.

IPC: H01J49/04

CPC classification number: H01J49/165 ,  G01N30/7246 ,  G01N30/7266 ,  H01J49/049

Abstract: An apparatus for efficiently removing a carrier liquid from charged liquid drops formed by electrospray ionization prior to introduction of the drops into a mass spectrometer (209). A central capillary tube (210) connects a region of the low pressure vacuum system containing the mass spectrometer (209) with a region at substantially atmospheric pressure, in which ion formation is produced by electrospray ionization. Heated, drying gas flows through a plurality of vortex forming channels (214) symmetrically disposed about the axis of the central capillary tube (210) which provides an entrance to the spectrometer (209). Gas exiting the vortex forming channels (214) enters tangentially to the inside of a vortex drying tube (222) with a small helix angle, causing the gas to swirl around the tube, forming a vortex. The vortex drying gas flows in a direction that is substantially transverse to the axis of the entrance capillary into the mass spectrometer (209). The vortex gas intersects the electrospray, separating undesired large drops from smaller drops by a vortex gas flow which imparts a centrifugal force to the drops. The largest drops are driven to the wall of the drying tube (222) and caused to fragment into smaller drops by evaporation and collision with the wall (222).

公开(公告)号：EP1118098A2

公开(公告)日：2001-07-25

申请号：EP99954672.4

申请日：1999-09-27

Applicant: Varian, Inc.

Inventor： WELLS, Gregory, J. ,  TONG, Roger, C. ,  YEE, Peter, P.

IPC: H01J49/04

CPC classification number: H01J49/165 ,  H01J49/0431

Abstract: An apparatus for electrospray ionization of a liquid sample matrix to prepare the sample for introduction into a mass spectrometer. The inventive electrospray interface is arranged between a source of a liquid sample matrix and an electrospray ionization needle. The interface includes a central chamber which contains elements for passively mixing the liquid sample flow with a modifying liquid added to the central chamber through a side channel. The side channel is isolated from the central chamber by a flow restrictor and the modifying liquid is provided to the side channel through a valve. A second valve, side channel, and flow restrictor are used to permit introduction of a calibration fluid into the central chamber through the first side channel. The inventive interface permits mixing of a modifying liquid with the liquid sample matrix to assist in nebulization of the liquid sample by reducing the surface tension of the sample containing fluid.

Abstract translation: 一种用于液体样品基质的电喷雾电离以制备样品以引入质谱仪的设备。 本发明的电喷雾界面布置在液体样品基质的源和电喷雾电离针之间。 该界面包括中央室，该中央室包含用于被动地将液体样品流与通过侧通道添加到中央室的改性液体混合的元件。 侧通道通过限流器与中央室隔离，并且改性液体通过阀提供到侧通道。 使用第二阀，侧通道和限流器以允许通过第一侧通道将校准流体引入到中央室中。 本发明的界面允许改性液体与液体样品基质混合，以通过降低含有流体的样品的表面张力来帮助液体样品的雾化。

公开(公告)号：EP1118097A1

公开(公告)日：2001-07-25

申请号：EP99954671.6

申请日：1999-09-27

Applicant: Varian, Inc.

Inventor： WELLS, Gregory, J. ,  TONG, Roger, C. ,  YEE, Peter, P.

IPC: H01J49/04

CPC classification number: H01J49/165 ,  G01N30/7246 ,  G01N30/7266 ,  H01J49/049

Abstract: An apparatus for efficiently removing a carrier liquid from charged liquid drops formed by electrospray ionization prior to introduction of the drops into a mass spectrometer (209). A central capillary tube (210) connects a region of the low pressure vacuum system containing the mass spectrometer (209) with a region at substantially atmospheric pressure, in which ion formation is produced by electrospray ionization. Heated, drying gas flows through a plurality of vortex forming channels (214) symmetrically disposed about the axis of the central capillary tube (210) which provides an entrance to the spectrometer (209). Gas exiting the vortex forming channels (214) enters tangentially to the inside of a vortex drying tube (222) with a small helix angle, causing the gas to swirl around the tube, forming a vortex. The vortex drying gas flows in a direction that is substantially transverse to the axis of the entrance capillary into the mass spectrometer (209). The vortex gas intersects the electrospray, separating undesired large drops from smaller drops by a vortex gas flow which imparts a centrifugal force to the drops. The largest drops are driven to the wall of the drying tube (222) and caused to fragment into smaller drops by evaporation and collision with the wall (222).