公开(公告)号：EP1648874B1

公开(公告)日：2011-10-05

申请号：EP04779562.0

申请日：2004-07-29

申请人： Xenon Pharmaceuticals Inc.

发明人： ABREO, Melwyn ,  CHAFEEV, Mikhail ,  CHAKKA, Nagasree ,  CHOWDHURY, Sultan ,  FU, Jian-Min ,  GSCHWEND, Heinz W. ,  HOLLADAY, Mark W. ,  HOU, Duanjie ,  KAMBOJ, Rajender ,  KODUMURU, Vishnumurthy ,  LI, Wenbao ,  LIU, Shifeng ,  RAINA, Vandna ,  SUN, Sengen ,  SUN, Shaoyi ,  SVIRIDOV, Serguei ,  TU, Chi ,  WINTHER, Michael D. ,  ZHANG, Zaihui

IPC分类号： C07D237/20 ,  C07D237/24 ,  A61K31/501 ,  A61P3/06

CPC分类号： A61K31/00 ,  A61K31/501 ,  A61K31/551 ,  C07D237/20 ,  C07D237/24

摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

公开(公告)号：EP1648874A2

公开(公告)日：2006-04-26

申请号：EP04779562.0

申请日：2004-07-29

申请人： XENON PHARMACEUTICALS INC.

发明人： ABREO, Melwyn ,  CHAFEEV, Mikhail ,  CHAKKA, Nagasree ,  CHOWDHURY, Sultan ,  FU, Jian-Min ,  GSCHWEND, Heinz W. ,  HOLLADAY, Mark W. ,  HOU, Duanjie ,  KAMBOJ, Rajender ,  KODUMURU, Vishnumurthy ,  LI, Wenbao ,  LIU, Shifeng ,  RAINA, Vandna ,  SUN, Sengen ,  SUN, Shaoyi ,  SVIRIDOV, Serguei ,  TU, Chi ,  WINTHER, Michael D. ,  ZHANG, Zaihui

IPC分类号： C07D237/20 ,  C07D237/24 ,  A61K31/501 ,  A61P3/06

CPC分类号： A61K31/00 ,  A61K31/501 ,  A61K31/551 ,  C07D237/20 ,  C07D237/24

摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.