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公开(公告)号：EP1851205B1
公开(公告)日：2012-04-11
申请号：EP06748193.7
申请日：2006-02-08
发明人： CHAKKA, Nagasree , CHAFEEV, Mikhail , CHOWDHURY, Sultan , FU, Jian-Min , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LIU, Shifeng , RAINA, Vandna , SUN, Shaoyi , SVIRIDOV, Serguei , WINTHER, Michael, D. , ZHANG, Zaihui , ABREO, Melwyn , HOLLADAY, Mark, W. , LI, Wenbao , SUN, Sengen , TU, Chi , GSCHWEND, Heinz, W.
IPC分类号： C07D237/20 , C07D237/22 , A61K31/501 , A61P3/06
CPC分类号： C07D237/20 , A61K31/00 , A61K31/501 , A61K31/551 , C07D237/22 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1799667B1
公开(公告)日：2013-03-20
申请号：EP05812357.1
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , CHOWDHURY, Sultan , LIU, Shifeng , KODUMURU, Vishnumurthy
IPC分类号： C07D401/04
CPC分类号： C07D213/82
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3.发明公开HETEROCYCLIC DERIVATIVES AND THEIR USE AS STEAROYL-COA DESATURASE INHIBITORS 有权杂环衍生物及其作为硬脂酰-coA去饱和酶抑制剂的用途
公开(公告)号：EP1804799A2
公开(公告)日：2007-07-11
申请号：EP05857721.4
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , RAINA, Vandna , SVIRIDOV, Serguei , KODUMURU, Vishnumurthy , CHAKKA, Nagasree , LIU, Shifeng , SUN, Shaoyi , HOU, Duanjie
IPC分类号： A61K31/501 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P1/06 , C07D403/00 , C07D237/00
CPC分类号： A61K31/501 , C07D237/24 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferebly a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, R2, R3, R5 , R5a, R6, R6a, R7, R7a, R8 and R8a are difined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了治疗哺乳动物，优选人的SCD介导的疾病或病症的方法，其中所述方法包括向需要其的哺乳动物施用式（I）的化合物：其中x，y，G，J，K ，L，M，W，R 2，R 3，R 5，R 5a，R 6，R 6a，R 7，R 7a，R 8和R 8a是本文定义的。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：EP1763350B1
公开(公告)日：2011-12-21
申请号：EP04756752.4
申请日：2004-07-06
发明人： FU, Jian-Min , KODUMURU, Vishnumurthy , SUN, Shaoyi , WINTHER, Michael, D. , FINE, Richard, M. , HARVEY, Daniel, F. , KLEBANSKY, Boris , GRAY-KELLER, Mark , GSCHWEND, Heinz, W. , LI, Wenbao
IPC分类号： A61K31/496 , C07D401/00 , A61P43/00 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： A61K31/496
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where m, n, p, V, R1, R2, R3, R4, R5 and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1851205A2
公开(公告)日：2007-11-07
申请号：EP06748193.7
申请日：2006-02-08
发明人： CHAKKA, Nagasree , CHAFEEV, Mikhail , CHOWDHURY, Sultan , FU, Jian-Min , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LIU, Shifeng , RAINA, Vandna , SUN, Shaoyi , SVIRIDOV, Serguei , WINTHER, Michael, D. , ZHANG, Zaihui , ABREO, Melwyn , HOLLADAY, Mark, W. , LI, Wenbao , SUN, Sengen , TU, Chi , GSCHWEND, Heinz, W.
IPC分类号： C07D237/20 , C07D237/22 , A61K31/501 , A61P3/06
CPC分类号： C07D237/20 , A61K31/00 , A61K31/501 , A61K31/551 , C07D237/22 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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6.发明公开HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY STEAROYL-COA DESATURASE ENZYMES 有权杂环衍生物用于治疗由硬脂酰辅酶A去饱和酶引起的疾病
公开(公告)号：EP1830837A2
公开(公告)日：2007-09-12
申请号：EP05808947.5
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , KODUMURU, Vishnumurthy , LIU, Shifeng , SUN, Shaoyi , CHAKKA, Nagasree
IPC分类号： A61K31/381 , A61K31/41 , A61K31/415 , C07D285/00 , C07D271/10 , C07D231/38 , C07D277/28 , A61P3/04
CPC分类号： C07D277/28 , A61K31/381 , A61K31/41 , A61K31/415 , C07D231/38 , C07D271/113 , C07D285/01
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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7.发明公开PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开PYRIDAZINDERIVATE UND DEREN VERWENDUNG ALS THERAPEUTISCHE WIRKSTOFFE
公开(公告)号：EP3042895A1
公开(公告)日：2016-07-13
申请号：EP16000190.5
申请日：2004-07-29
发明人： Abreo, Melwyn , Chafev, Mikhail , Chakka, Nagasree , Chowdhury, Sultan , FU, Jian-Min , Gschwend, Heinz W. , Holladay, Mark W. , HOU, Duanjie , Kamboj, Rajender , Kodumuru, Vishnumurthy , LI, Wenbao , LIU, Shifeng , Raina, Vandna , SUN, Sengen , SUN, Shaoyi , Sviridov, Serguei , TU, Chi , Winther, Michael D. , Zhang, Zaihui
IPC分类号： C07D237/20 , C07D237/22 , A61K31/501 , A61P3/06
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I):
where x, y, W, V, R 2 , R 3 , R 4 , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , R 8a , R 9 and R 9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.摘要翻译： 公开了治疗哺乳动物，优选人类的SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，W，V，R 2，R 3，R 4，R 5，R 6，R 6a，R 7，R 7a，R 8，R 8a，R 9和R 9a如本文所定义。 还公开了包含式（I）化合物的药物组合物。
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8.发明授权HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY STEAROYL-COA DESATURASE ENZYMES 有权杂环衍生物用于治疗由硬脂酰辅酶A去饱和酶引起的疾病
公开(公告)号：EP1830837B1
公开(公告)日：2013-09-04
申请号：EP05808947.5
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , KODUMURU, Vishnumurthy , LIU, Shifeng , SUN, Shaoyi , CHAKKA, Nagasree
IPC分类号： A61K31/381 , A61K31/41 , A61K31/415 , C07D285/00 , C07D271/10 , C07D231/38 , C07D277/28 , A61P3/04
CPC分类号： C07D277/28 , A61K31/381 , A61K31/41 , A61K31/415 , C07D231/38 , C07D271/113 , C07D285/01
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公开(公告)号：EP1648874B1
公开(公告)日：2011-10-05
申请号：EP04779562.0
申请日：2004-07-29
发明人： ABREO, Melwyn , CHAFEEV, Mikhail , CHAKKA, Nagasree , CHOWDHURY, Sultan , FU, Jian-Min , GSCHWEND, Heinz W. , HOLLADAY, Mark W. , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LI, Wenbao , LIU, Shifeng , RAINA, Vandna , SUN, Sengen , SUN, Shaoyi , SVIRIDOV, Serguei , TU, Chi , WINTHER, Michael D. , ZHANG, Zaihui
IPC分类号： C07D237/20 , C07D237/24 , A61K31/501 , A61P3/06
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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10.发明公开
公开(公告)号：EP1814551A2
公开(公告)日：2007-08-08
申请号：EP05813076.6
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , SVIRIDOV, Serguei , CHOWDHURY, Sultan , KODUMURU, Vishnumurthy
IPC分类号： A61K31/501
CPC分类号： C07D401/12 , A61K31/501 , C07D237/24 , C07D403/12
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, G, J, K, L, M, Q, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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