公开(公告)号：EP2044118A2

公开(公告)日：2009-04-08

申请号：EP07798524.0

申请日：2007-06-13

申请人： Zymogenetics, Inc.

发明人： LEWIS, Katherine, E. ,  PRESNELL, Scott R. ,  WEST, James, W. ,  MABRY, Robert, ,  MEENGS, Brent

IPC分类号： C07K16/24 ,  C12N15/13 ,  A61K39/395 ,  A61P37/06

CPC分类号： C07K16/244 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.