公开(公告)号：EP1931697A2

公开(公告)日：2008-06-18

申请号：EP06815733.8

申请日：2006-09-28

申请人： ZymoGenetics, Inc.

发明人： LEVIN, Steven, D. ,  RIXON, Mark, W. ,  GAO, Zeren ,  LEWIS, Katherine, E. ,  BILLSBOROUGH, Janine ,  TAFT, David, W.

IPC分类号： C07K14/00 ,  C07K16/28

CPC分类号： C07K14/54 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30

摘要： The present invention relates antagonists of IL-17A and IL-17F. The antagonists of the invention are based on IL-17RC alone or on both IL-17RC and IL-17RA ('IL-17RC/IL-17RA') . Such antagonists serve to block, inhibit, reduce, antagonize or neutralize the activity of IL-17F, IL-17A, or both IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. IL- 17RA is a receptor for IL-17A and IL-17RC is a common receptor for both IL-17A and IL-17F. The present invention includes soluble IL-17A and IL-17F antagonists, as well as methods for using the same.

公开(公告)号：EP1551440A2

公开(公告)日：2005-07-13

申请号：EP03786525.0

申请日：2003-10-07

申请人： ZymoGenetics, Inc.

发明人： THOMPSON, Penny, J. ,  LEWIS, Katherine, E. ,  JASPERS, Stephen, R. ,  GARCIA, Richard, M. ,  WEST, Robert, R. ,  HOLDERMAN, Susan, D. ,  CHAN, Chung

IPC分类号： A61K38/00 ,  C07K14/00 ,  C12N5/02 ,  C12N15/74

CPC分类号： A61K38/1709 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4702 ,  G01N2800/06

摘要： The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal funciton with Zven1 and Zven2 polypeptides.

公开(公告)号：EP2044118A2

公开(公告)日：2009-04-08

申请号：EP07798524.0

申请日：2007-06-13

申请人： Zymogenetics, Inc.

发明人： LEWIS, Katherine, E. ,  PRESNELL, Scott R. ,  WEST, James, W. ,  MABRY, Robert, ,  MEENGS, Brent

IPC分类号： C07K16/24 ,  C12N15/13 ,  A61K39/395 ,  A61P37/06

CPC分类号： C07K16/244 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.

公开(公告)号：EP2150564A2

公开(公告)日：2010-02-10

申请号：EP08754949.9

申请日：2008-04-28

申请人： ZymoGenetics, Inc.

发明人： LEWIS, Katherine, E. ,  PRESNELL, Scott, R. ,  LEVIN, Steven, D.

IPC分类号： C07K16/24 ,  C07K16/46 ,  A61K39/395 ,  A61P37/06

CPC分类号： C07K16/244 ,  A61K2039/507 ,  C07K2317/31 ,  C07K2317/56

摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.

公开(公告)号：EP1931708A1

公开(公告)日：2008-06-18

申请号：EP06817108.1

申请日：2006-10-18

申请人： Zymogenetics, Inc.

发明人： GAO, Zeren, ,  KUESTNER, Rolf, E. ,  APPLEBY, Mark, W. ,  LEWIS, Katherine, E. ,  MCKERNAN, Patricia, A. ,  OKADA, Shannon, L. ,  TAFT, David, W. ,  KUIJPER, Joseph, L. ,  JASPERS, Stephen, R. ,  LEVIN, Steven, D.

IPC分类号： C07K14/715 ,  C12N15/62 ,  C12N15/12 ,  A61K38/17

CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K2319/20 ,  C07K2319/21 ,  C07K2319/30

摘要： The present invention relates IL-17RE antagonists, such as soluble receptors and anti-IL-17RE antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. IL-17RE is a receptor for IL-17C. The present invention includes soluble IL-17RE, anti-IL-17RE antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.

公开(公告)号：EP1802657A2

公开(公告)日：2007-07-04

申请号：EP05818898.8

申请日：2005-10-18

申请人： ZymoGenetics, Inc.

发明人： GAO, Zeren ,  KUESTNER, Rolf, E. ,  APPLEBY, Mark, W. ,  LEWIS, Katherine, E. ,  MCKERNAN, Patricia, A. ,  OKADA, Shannon, L. ,  TAFT, David, W. ,  KUIJPER, Joseph, L. ,  JASPERS, Stephen, R. ,  LEVIN, Steven, D.

IPC分类号： C07K14/715

CPC分类号： C07K14/7155 ,  A61K38/00 ,  A61K39/395 ,  A61K47/50 ,  A61K47/60 ,  C07K14/54 ,  C07K16/00

摘要： The present invention relates ZcytoR21 antagonists, such as soluble receptors and anti-ZcytoR21 antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. ZcytoR21 is a receptor for IL-17C. The present invention includes soluble ZcytoR21, anti-ZcytoR21 antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.