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公开(公告)号：EP3344641A1
公开(公告)日：2018-07-11
申请号：EP16840988.6
申请日：2016-09-02
发明人： BAASOV, Timor , TUVIA, Shmuel
IPC分类号： C07H15/23 , A61K31/7036 , A61P7/04 , A61P21/00 , A61P21/04 , C07H15/222 , C07H15/224
CPC分类号： C07H15/224 , C07H15/23
摘要： Novel aminoglycosides, represented by Formulae Ia and Ib, as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
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2.发明公开USE OF AMINOGLYCOSIDE ANALOGS IN THE TREATMENT OF RETT SYNDROME 审中-公开VERWENDUNG VON AMINOGLYCOSID-ANALOGA BEI DER BEHANDLUNG DES RETT-SYNDROMS
公开(公告)号：EP3151840A1
公开(公告)日：2017-04-12
申请号：EP15735743.5
申请日：2015-06-04
发明人： BAASOV, Timor , TUVIA, Shmuel , PELLED, Dori
IPC分类号： A61K31/7036 , A61P25/00 , A61P43/00
CPC分类号： A61K31/7036
摘要： or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification, in the treatment of Rett syndrome are disclosed.
摘要翻译： 由通式I表示的假三糖氨基糖苷类或其药学上可接受的盐的化合物，方法和用途，其中R 1选自烷基，环烷基和芳基; 并且所有其他变量和特征如说明书中所述，在Rett综合征的治疗中被公开。
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公开(公告)号：EP3634973A1
公开(公告)日：2020-04-15
申请号：EP18814198.0
申请日：2018-06-05
发明人： BAASOV, Timor , FIRZON, Vera , BELAKHOV, Valery , EYLON, Bat-Hen
IPC分类号： C07H15/224 , C07H15/23 , C07H15/222 , A61P21/04 , A61P21/00
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4.发明公开
公开(公告)号：EP3609902A1
公开(公告)日：2020-02-19
申请号：EP18767330.6
申请日：2018-03-15
IPC分类号： C07H5/06 , C07H15/224 , C07H15/232 , A61K31/7036
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公开(公告)号：EP3400232A1
公开(公告)日：2018-11-14
申请号：EP16883508.0
申请日：2016-09-02
发明人： BAASOV, Timor , TUVIA, Shmuel
IPC分类号： C07H15/23 , A61K31/7036 , A61P7/04 , A61P21/00 , A61P21/04 , C07H15/222 , C07H15/224
CPC分类号： C07H15/23 , C07H15/224
摘要： Novel aminoglycosides, represented by Formulae (I), (Ia), (III) and (IIIa), as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
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公开(公告)号：EP3350194A1
公开(公告)日：2018-07-25
申请号：EP16840987.8
申请日：2016-09-02
发明人： BAASOV, Timor
IPC分类号： C07H15/23 , A61K31/7036 , A61P7/04 , A61P21/00 , A61P21/04
CPC分类号： A61K31/7036 , A61P7/04 , A61P21/04 , C07H15/23
摘要： Novel pseudo-trisaccharide aminoglycosides, represented by Formula I, as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
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公开(公告)号：EP3344640A1
公开(公告)日：2018-07-11
申请号：EP16840986.0
申请日：2016-09-02
发明人： BAASOV, Timor
IPC分类号： C07H15/23 , A61K31/7036 , A61P7/04 , A61P21/04 , C07H15/222 , C07H15/224
CPC分类号： C07H15/224 , A61P7/04 , A61P7/12 , A61P21/04 , C07H15/23
摘要： Novel pseudo-disaccharide and pseudo-trisaccharide aminoglycosides, represented by Formulae I or Ia, as defined in the instant specification, designed to exhibit stop codon mutation readthrough activity, are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic diseases and disorders, such as diseases and disorders associated with stop codon mutations.
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