公开(公告)号：EP4488281A1

公开(公告)日：2025-01-08

申请号：EP23763353.2

申请日：2023-02-24

Applicant: OSAKA UNIVERSITY ,  Japan As Represented By Director General Of National Institute Of Health Sciences

Inventor： OBIKA, Satoshi ,  YAMAGUCHI, Takao ,  SAKAUE, Shiori ,  INOUE, Takao ,  YOSHIDA, Tokuyuki

IPC: C07H19/073 ,  A61K9/06 ,  A61K9/08 ,  A61K31/7088 ,  A61K48/00 ,  A61P21/00 ,  A61P21/04 ,  A61P31/12 ,  A61P35/00 ,  A61P43/00 ,  C07H19/10 ,  C07H19/173 ,  C07H21/04 ,  C12N5/10 ,  C12N15/10 ,  C12N15/11 ,  C12N15/113

Abstract: A 5'-modified nucleoside and a nucleotide using the same are disclosed. The nucleoside of the present invention is a compound represented by a formula (I) below or a salt thereof. The nucleoside of the present invention has a suitable double-strand forming ability for a target RNA and an excellent nuclease-resistant ability and can be produced with high efficiency without the need for an operation for separating diastereomers in the pathway for the synthesis thereof. The nucleoside of the present invention is usable as an alternative to phosphorothioate-modified nucleic acids, which have a risk of, for example, accumulation in a specific organ, and also has high industrial productivity.

公开(公告)号：EP4374922A3

公开(公告)日：2024-08-28

申请号：EP24156366.7

申请日：2017-06-13

Applicant: Regeneron Pharmaceuticals, Inc.

Inventor： HU, Ying ,  LATUSZEK, Adrianna ,  ROMANO, Carmelo ,  OLSON, William

IPC: C07K16/18 ,  A61P1/04 ,  A61K39/00 ,  A61P3/04 ,  A61P3/10 ,  A61P7/00 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/10 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/08

CPC classification number: A61K2039/50520130101 ,  C07K16/18 ,  C07K2317/2120130101 ,  C07K2317/3320130101 ,  C07K2317/3420130101 ,  C07K2317/7620130101 ,  C07K2317/9220130101 ,  C07K2317/9420130101 ,  A61P1/04 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/10 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P3/04 ,  A61P31/00 ,  A61P31/04 ,  A61P3/10 ,  A61P37/02 ,  A61P37/06 ,  A61P7/00 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10

Abstract: The present invention provides monoclonal antibodies that bind to the complement factor 5 (C5) protein, and methods of use thereof. In various embodiments of the invention, the antibodies are fully human antibodies that bind to C5 protein. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing C5 activity, thus providing a means of treating or preventing a C5-related disease or disorder in humans. In some embodiments, the invention provides for an anti-C5 antibody that has improved pharmacokinetic and pharmacodynamic properties, e.g., a half-life of more than 10 days.

公开(公告)号：EP3986873B9

公开(公告)日：2024-05-29

申请号：EP20734158.7

申请日：2020-06-19

IPC: C07D257/04 ,  C07D207/12 ,  C07D261/08 ,  C07D285/08 ,  C07D249/08 ,  C07D271/06 ,  C07C259/00 ,  C07C261/04 ,  C07C259/14 ,  C07C311/51 ,  A61K31/40 ,  A61K31/41 ,  A61K31/433 ,  A61K31/165 ,  A61K31/277 ,  A61P21/00 ,  A61P21/02 ,  A61P21/04

CPC classification number: A61P21/00 ,  A61P21/02 ,  A61P21/04 ,  C07C261/04 ,  C07C311/51 ,  C07D207/12 ,  C07D257/04 ,  C07D261/08 ,  C07D285/08 ,  C07D271/06 ,  C07D249/08

公开(公告)号：EP3721892B1

公开(公告)日：2024-05-22

申请号：EP20160287.7

申请日：2015-06-04

IPC: A61K38/00 ,  A61K38/16 ,  A61P21/06 ,  C07K14/47 ,  C07K19/00 ,  C12N15/62 ,  A61K38/17 ,  A61P21/00 ,  A61P21/04

CPC classification number: A61K38/00 ,  C07K2319/3020130101 ,  A61K38/1709 ,  A61P21/06 ,  C07K14/4703 ,  A61P21/00 ,  A61P21/04

公开(公告)号：EP4346816A2

公开(公告)日：2024-04-10

申请号：EP22733550.2

申请日：2022-05-31

Applicant: Cellestia Biotech AG

Inventor： LEHAL, Rajwinder ,  VIGOLO, Michele ,  MAGNIN, Morgane ,  LAMY, Sebastien

IPC: A61K31/44 ,  A61K31/4412 ,  A61K31/351 ,  A61P17/06 ,  A61P19/02 ,  A61P21/04 ,  A61P29/00 ,  A61P37/00

公开(公告)号：EP3065721B1

公开(公告)日：2024-03-13

申请号：EP14795634.6

申请日：2014-11-07

Inventor： COULTER, Ivan ,  AVERSA, Vincenzo ,  ROSA, Monica

IPC: A61K9/50 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P15/00 ,  A61K38/13 ,  A61P17/00 ,  A61P19/02 ,  A61P21/04 ,  A61P17/06 ,  A61P29/00 ,  A61P35/00 ,  A61P37/08 ,  A61P37/06

公开(公告)号：EP3654989B1

公开(公告)日：2024-01-03

申请号：EP18739593.4

申请日：2018-06-28

Inventor： REJDAK, Konrad

IPC: A61K31/7076 ,  A61P21/04 ,  A61P37/06

公开(公告)号：EP4279084A1

公开(公告)日：2023-11-22

申请号：EP23191483.9

申请日：2016-10-28

Applicant: Vertex Pharmaceuticals Inc.

Inventor： KABADI, Ami, Meda ,  COWAN, Chad, Albert ,  LUNDBERG, Ante, Sven

IPC: A61K38/46 ,  A61K48/00 ,  C07K14/47 ,  C12N9/22 ,  C12N9/96 ,  C12N15/85 ,  C12N15/90 ,  C12N15/10 ,  C12N5/074 ,  C12N5/077 ,  C12N5/0775 ,  A61K35/28 ,  A61K35/34 ,  A61P21/00 ,  A61P21/04 ,  A61P25/14 ,  C12N15/113

Abstract: The present application provides materials and methods for treating a patient with Duchenne Muscular Dystrophy (DMD) both ex vivo and in vivo. In addition, the present application provides materials and methods for editing a dystrophin gene in a cell by genome editing.

公开(公告)号：EP4223297A3

公开(公告)日：2023-11-15

申请号：EP23165202.5

申请日：2017-07-25

Applicant: WisTa Laboratories Ltd.

Inventor： WISCHIK, Claude Michel ,  SCHELTER, Björn Olaf ,  WISCHIK, Damon Jude ,  STOREY, John Mervyn David

IPC: A61K31/5415 ,  A61P25/28 ,  A61P9/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/00 ,  A61P25/02 ,  A61P3/02 ,  A61P25/14 ,  A61P25/16 ,  A61P43/00

Abstract: The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels.

公开(公告)号：EP3321259B1

公开(公告)日：2023-10-04

申请号：EP16820624.1

申请日：2016-07-04

Inventor： WANG, Yuqiang ,  YU, Pei ,  SUN, Yewei ,  SHAN, Luchen ,  ZHANG, Gaoxiao ,  ZHANG, Zaijun ,  YI, Peng

IPC: C07D241/12 ,  A61K31/497 ,  A61P9/00 ,  A61P9/10 ,  A61P7/02 ,  A61P11/00 ,  A61P25/28 ,  A61P25/16 ,  A61P25/14 ,  A61P21/00 ,  A61P21/04 ,  A61P27/06