公开(公告)号：EP3359652A1

公开(公告)日：2018-08-15

申请号：EP16854065.6

申请日：2016-09-20

申请人： The University of North Carolina at Chapel Hill

发明人： METZ, Stefan ,  DESILVA, Aravinda ,  MILEY, Michael

IPC分类号： C12N7/04 ,  C07K14/005 ,  G01N33/53 ,  A61K39/12

CPC分类号： A61K39/12 ,  A61P31/14 ,  C07K14/005 ,  C07K2319/21 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24151 ,  G01N33/56983 ,  G01N33/6854 ,  G01N2333/185 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/396 ,  Y02A50/53

摘要： The present invention provides compositions directed to recombinant flavivirus E glycoprotein ectodomain dimers for use in diagnostic and immunotherapeutic methods.

公开(公告)号：EP3347043A1

公开(公告)日：2018-07-18

申请号：EP16782176.8

申请日：2016-09-06

申请人： Fundação Butantan

发明人： GALLINA, Neuza Maria Frazatti

IPC分类号： A61K39/12

CPC分类号： A61K39/12 ,  A61K9/19 ,  A61K2039/5254 ,  A61K2039/70 ,  B65B3/003 ,  C12N7/00 ,  C12N2770/24134 ,  C12N2770/24151 ,  C12N2770/24164 ,  Y02A50/386

摘要： The present invention refers to a process for preparing an attenuated tetravalent dengue vaccine and its product. The present invention also refers to a process for preparing a tetravalent dengue vaccine for administration to a subject, to a method for inducing an immune response to virus dengue serotype 1, 2, 3 and 4 in a patient and to a tetravalent dengue vaccine kit.

公开(公告)号：EP2043681B1

公开(公告)日：2015-10-07

申请号：EP07852387.5

申请日：2007-07-16

申请人： Sanofi Pasteur Biologics, LLC

发明人： PUGACHEV, Konstantin, V. ,  RUMYANTSEV, Alexander, A.

IPC分类号： A61K39/12 ,  C12N7/02

CPC分类号： C12N7/00 ,  A61K2039/5256 ,  C12N15/86 ,  C12N2770/24143 ,  C12N2770/24151 ,  C12N2800/50 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396

摘要： The invention provides viral vectors, such as chimeric flavivirus vectors, including foreign peptides inserted into the target proteins of the vectors, methods of making and using these vectors, and compositions including the vectors.

公开(公告)号：EP1739167B1

公开(公告)日：2015-08-12

申请号：EP05734402.0

申请日：2005-04-19

申请人： DENKA SEIKEN Co., Ltd. ,  Sanyo Chemical Industries, Ltd.

发明人： KAI, Hikaru, Denka Seiken Co., LTD. ,  TSUBAKI, Masayuki, Denka Seiken Co., LTD. ,  KUROKAWA, Masato, Sanyo Chemical Industries, LTD.

IPC分类号： C12N5/071

CPC分类号： C12N7/00 ,  C12N2760/16051 ,  C12N2770/24151

公开(公告)号：EP1604685B1

公开(公告)日：2012-02-22

申请号：EP05014317.1

申请日：1998-08-25

申请人： CJ Cheiljedang Corporation ,  Walter Reed Army Institute of Research

发明人： Kim, Hyun, Su ,  Yoo, Wang, Don ,  Kim, Soo, Ok ,  Lee, Sung, hee ,  Moon, Sang, Bum ,  Hong, Sun, Pyo ,  Shin, Yong, Cheol ,  Chung, Yong, Ju ,  Eckels, Kenneth, H. Walter Reed Army ,  Innis, Bruce Walter Reed Army ,  Putnak, Joseph, R. Walter Reed Army ,  Binn, Leonard, N. Walter Reed Army ,  Dubois, Doria, R. Walter Reed Army ,  Srivastava, Ashok, I. Walter Reed Army

IPC分类号： A61K39/12 ,  C07K14/18

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/55505 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24151 ,  Y02A50/39

摘要： A vaccine comprises Japanese encephalitis virus and aluminium hydroxide as adjuvant.

公开(公告)号：EP2043681A4

公开(公告)日：2009-11-25

申请号：EP07852387

申请日：2007-07-16

申请人： SANOFI PASTEUR BIOLOGICS CO

发明人： PUGACHEV KONSTANTIN V ,  RUMYANTSEV ALEXANDER A

IPC分类号： A61K39/12 ,  C12N7/02

CPC分类号： C12N7/00 ,  A61K2039/5256 ,  C12N15/86 ,  C12N2770/24143 ,  C12N2770/24151 ,  C12N2800/50

摘要： The invention provides viral vectors, such as chimeric flavivirus vectors, including foreign peptides inserted into the target proteins of the vectors, methods of making and using these vectors, and compositions including the vectors.

公开(公告)号：EP1213030B1

公开(公告)日：2009-04-22

申请号：EP01130212.2

申请日：1995-11-10

申请人： Baxter Healthcare SA

发明人： Kistner, Otfried ,  Barret, Noel ,  Mundt, Wolfgang ,  Dorner, Friedrich

IPC分类号： A61K39/12 ,  C12N7/00 ,  A61K39/15

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/245 ,  A61K2039/5252 ,  A61K2039/55505 ,  C12N7/00 ,  C12N2500/95 ,  C12N2710/16634 ,  C12N2710/16651 ,  C12N2710/24151 ,  C12N2720/12351 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16234 ,  C12N2770/24151 ,  Y02A50/388 ,  Y02A50/396 ,  Y02A50/464

摘要： The present invention refers to a method for producing viruses, selected from the group of flaviviridae, poxviridae and reoviridae and vaccines derived therefrom as well as to cells cultured under protein-free conditions. These cells show improved capabilities for propagating viruses, and eliminate the need for costly and time-consuming viral passaging und purification.

公开(公告)号：EP1604685A3

公开(公告)日：2006-07-05

申请号：EP05014317.1

申请日：1998-08-25

申请人： Cheil Jedang Corporation ,  Walter Reed Army Institute of Research

发明人： Kim, Hyun, Su ,  Yoo, Wang, Don ,  Kim, Soo, Ok ,  Lee, Sung, hee ,  Moon, Sang, Bum ,  Hong, Sun, Pyo ,  Shin, Yong, Cheol ,  Chung, Yong, Ju ,  Eckels, Kenneth, H. Walter Reed Army ,  Innis, Bruce Walter Reed Army ,  Putnak, Joseph, R. Walter Reed Army ,  Binn, Leonard, N. Walter Reed Army ,  Dubois, Doria, R. Walter Reed Army ,  Srivastava, Ashok, I. Walter Reed Army

IPC分类号： A61K39/12 ,  C07K14/18

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/55505 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24151 ,  Y02A50/39

摘要： A vaccine comprises Japanese encephalitis virus and aluminium hydroxide as adjuvant.

摘要翻译： 疫苗包括日本脑炎病毒和氢氧化铝作为佐剂。

公开(公告)号：EP1604685A2

公开(公告)日：2005-12-14

申请号：EP05014317.1

申请日：1998-08-25

申请人： Cheil Jedang Corporation ,  Walter Reed Army Institute of Research

发明人： Kim, Hyun, Su ,  Yoo, Wang, Don ,  Kim, Soo, Ok ,  Lee, Sung, hee ,  Moon, Sang, Bum ,  Hong, Sun, Pyo ,  Shin, Yong, Cheol ,  Chung, Yong, Ju ,  Eckels, Kenneth, H. Walter Reed Army ,  Innis, Bruce Walter Reed Army ,  Putnak, Joseph, R. Walter Reed Army ,  Binn, Leonard, N. Walter Reed Army ,  Dubois, Doria, R. Walter Reed Army ,  Srivastava, Ashok, I. Walter Reed Army

IPC分类号： A61K39/12

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/55505 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24151 ,  Y02A50/39

摘要： A vaccine comprises Japanese encephalitis virus and aluminium hydroxide as adjuvant.

公开(公告)号：EP0841942B1

公开(公告)日：2003-01-29

申请号：EP96927102.2

申请日：1996-07-29

申请人： Aventis Pasteur

发明人： FANGET, Bernard ,  FRANCON, Alain ,  HEIMENDINGER, Pierre

IPC分类号： A61K39/12 ,  C12N7/02

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5252 ,  C12N2770/24134 ,  C12N2770/24151 ,  Y02A50/39

摘要： A method is disclosed for industrially producing a Japanese encephalitis vaccine, wherein (a) cells from a cell line are cultured, (b) the resulting cell culture is inoculated with a Japanese encephalitis virus in the presence of a viral growth medium, (c) the virus is propagated and multiplied on the cells, (d) the viral growth medium is recovered in the form of a suspension of viruses produced by the cells, (e) the virus suspension is purified in at least one ion exchange chromatography step and a gel permeation step, and (f) the virus suspension is formulated and converted into a pharmaceutical form to preserve it until the moment of use. A Japanese encephalitis vaccine characterised in that it comprises a Japanese encephalitis virus produced by culturing cells from a cell line, and in that the cellular DNA content is less than 100 pg/dose, is also disclosed.