公开(公告)号：EP2972381A2

公开(公告)日：2016-01-20

申请号：EP14708867.8

申请日：2014-03-07

申请人： Galapagos NV

发明人： JANSSEN, Richard Antonius Jozef ,  LEKKERKERKER, Annemarie Nicolette ,  AARBIOU, Jamil

IPC分类号： G01N33/68 ,  C12Q1/68

CPC分类号： G01N33/5073 ,  A01K67/027 ,  A01K2207/10 ,  A01K2207/30 ,  A01K2227/105 ,  A01K2267/03 ,  C07K16/18 ,  C07K16/40 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2320/10 ,  C12N2320/12 ,  C12N2320/30 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Y204/0203 ,  C12Y207/11001 ,  C12Y207/11015 ,  C12Y207/12001 ,  G01N33/5011 ,  G01N33/5044 ,  G01N2333/70596 ,  G01N2333/78 ,  G01N2333/96486 ,  G01N2500/04 ,  G01N2500/10

摘要： The present invention relates to methods and assays for identifying agents useful in the treatment of diseases associated with epithelial mesenchymal transition(EMT), in particular fibrotic diseases and cancer. The invention provides polypeptide and nucleic acid TARGETs, siRNA sequences based on these TARGETs and antibodies against the TARGETs. The invention is further related to pharmaceutical composition comprising siRNA sequences based on the TARGETs and antibodies against the TARGETs for use in the treatment of diseases associated withepithelial mesenchymal transition, in particular fibrotic disease and cancer. The invention further provides
in vitro methods for inhibition of epithelial mesenchymal transition.