公开(公告)号：EP1600168A2

公开(公告)日：2005-11-30

申请号：EP05019211.1

申请日：2000-11-27

申请人： UCB, S.A.

发明人： Lamberty, Yves ,  Matagne, Alain ,  Klitgaard, Henrik ,  Waegemans, Tony

IPC分类号： A61K45/06 ,  A61K31/4015 ,  A61P25/18 ,  A61K31/19

CPC分类号： A61K45/06 ,  A61K31/19 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/515 ,  A61K31/55 ,  A61K31/56 ,  Y10S514/922 ,  A61K2300/00

摘要： A use of (S)-(-)-α-ethyl-2-oxo-1-pyrrolidineacetamide for the manufacture of a medicament for treatment of particular diseases and new pharmaceutical compositions comprising (S)-(-)-α-ethyl-2-oxo-1-pyrrolidineacetamide.

摘要翻译： （S） - （ - ） - - - - 乙基-2-氧代-1-吡咯烷乙酰胺用于制备用于治疗特定疾病的药物的用途和包含（S） - （ - ） - 2-氧代-1-吡咯烷乙酰胺。

公开(公告)号：EP1587620A1

公开(公告)日：2005-10-26

申请号：EP04700999.8

申请日：2004-01-09

申请人： UCB, S.A.

发明人： JACOBS, Pierre ,  COLLIGNON, François ,  VAN VAERENBERGH, Emmanuel ,  SURTEES, John ,  BURTEAU, Anne-Catherine

IPC分类号： B01J29/70 ,  B01J23/46 ,  B01J31/18

CPC分类号： C07B53/00 ,  B01J29/70 ,  B01J31/2414 ,  B01J2231/645 ,  B01J2531/822 ,  C07D207/27

摘要： A catalyst comprising a chiral transition metal-(1,2-bis(2,5-dialkylphospholano) complex immobilised on a specific zeolitic support useful for the hydrogenation of prochiral substrates.

公开(公告)号：EP1254104B1

公开(公告)日：2005-04-13

申请号：EP00986919.9

申请日：2000-12-15

申请人： UCB FARCHIM, S.A.

发明人： CHOI, Lewis, Siu, Leung ,  BEATCH, Gregory, N. ,  PAGE, Clive, P.

IPC分类号： C07C217/14 ,  C07C217/30 ,  C07D211/14 ,  A61K31/135 ,  A61P11/14

CPC分类号： C07D209/08 ,  C07C217/18 ,  C07C217/30

摘要： In one aspect, the present invention concerns the use of certain quaternary ammonium compounds as active ingredient in the manufacture of a medicament for use in the treatment and/or prevention of cough in warm-blooded animals, including humans, such as compounds of formula Y-J-E An- (I), wherein J is independently selected from a group represented by one of formulae (II), (III) and (IV).

公开(公告)号：EP1465607A1

公开(公告)日：2004-10-13

申请号：EP03701497.4

申请日：2003-01-08

申请人： UCB, S.A.

发明人： BERWAER, Monique ,  DELEERS, Michel ,  FANARA, Domenico ,  GUICHAUX, Anthony

IPC分类号： A61K9/24 ,  A61K31/495

CPC分类号： A61K9/209 ,  A61K31/495

摘要： The invention relates to a pharmaceutical formulation to be administered orally, which contains efletirizine as an active principle and has a fast-release fraction and a timed-release fraction.

公开(公告)号：EP1447399A1

公开(公告)日：2004-08-18

申请号：EP04007733.1

申请日：2001-02-21

申请人： UCB, S.A.

发明人： Differding, Edmond ,  Kenda, Benoît ,  Lallemand, Bénédicte ,  Matagne, Alain ,  Michel, Philippe ,  Pasau, Patrick ,  Talaga, Patrice

IPC分类号： C07D207/27 ,  A61K31/4015 ,  A61P25/08

CPC分类号： C07D207/26 ,  A61K31/4015 ,  C07C237/12 ,  C07D207/27 ,  C07D207/273 ,  C07D207/277 ,  C07D307/33 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/12 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D495/04

摘要： A compound selected from (2S)-2-[(4S)-4-(2,2-difluorovinyl)-2-oxopyrrolidinyl]butanamide or a pharmaceutically acceptable salt thereof.
The compounds of the invention are particularly suited for treating neurological disorders such as epilepsy.

摘要翻译： 选自（2S）-2 - [（4S）-4-（2,2-二氟乙烯基）-2-氧代吡咯烷基]丁酰胺或其药学上可接受的盐的化合物。 本发明的化合物特别适用于治疗神经疾病如癫痫。

公开(公告)号：EP1435943A2

公开(公告)日：2004-07-14

申请号：EP02774687.4

申请日：2002-10-07

申请人： UCB, S.A.

发明人： GRIMEE, Renee ,  KLITGAARD, Henrik

IPC分类号： A61K31/4015 ,  A61P25/14

CPC分类号： A61K31/4015

摘要： The present invention relates to the use of 2-oxo-1-pyrrolidine derivatives (and in particular (S)-(-)-α-ethyl-2-oxo-1-pyrrolidineacetamide) for the preparation of drugs for the curative and/or prophylactic treatment of dyskinesia

公开(公告)号：EP1419144A2

公开(公告)日：2004-05-19

申请号：EP02764832.8

申请日：2002-08-05

申请人： UCB, S.A.

发明人： ATES, Célal ,  SURTEES, John ,  BURTEAU, Anne-Catherine ,  MARMON, Violeta ,  CAVOY, Emile

IPC分类号： C07D207/26

CPC分类号： C07D207/27 ,  C07D207/26

摘要： The present invention relates to an improved process for the preparation of (S)-(-)-α-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R1 is methyl or ethyl ; and R2 is C2'-C4191 alkyl, C2191-C4191 alkenyl or C2191-C41 91 alkynyl, optionally substituted by one or more halogen, and their preparation processes.

公开(公告)号：EP1414460A1

公开(公告)日：2004-05-06

申请号：EP02758376.4

申请日：2002-07-22

申请人： UCB, S.A.

发明人： DIOUF, Ousmane ,  SURTEES, John

IPC分类号： A61K31/495 ,  C07D295/088

CPC分类号： C07D295/088 ,  A61K31/495

摘要： The present invention relates to a process for the manufacture of 2-{2-[4-(bis(4-fluorophenyl)methyl)-1-piperazinyl]ethoxy}acetic acids, amides or related derivatives, of the general formula (I) wherein: Y represents hydroxy or -NR1R2; R1 and R2 each independently represent hydrogen or C?1-4#191 alkyl; m is 1 or 2, and n is 1 or 2, as well as the non-toxic, pharmaceutically acceptable salts and mixtures thereof. The present invention concerns also a polymorphic form of efletirizine.

公开(公告)号：EP1356034A2

公开(公告)日：2003-10-29

申请号：EP01987251.4

申请日：2001-12-07

申请人： UCB, S.A.

发明人： NOCKA, Karl ,  PIROZZI, Gregorio ,  EINSTEIN, Richard

IPC分类号： C12N15/00

CPC分类号： C07K14/47 ,  A01K2217/075

摘要： The invention relates generally to the changes in gene expression in mast cells during maturation and in tissues removed from patients with urticaria or allergic hypersensitivity relative to gene expression in mast cells removed from normal subjects. The invention specifically relates to four novel gene families which are differentially expressed in mast cells and allergic hypersensitivity diseases, such as urticaria, compared to normal tissues.

公开(公告)号：EP1244456A1

公开(公告)日：2002-10-02

申请号：EP00977580.0

申请日：2000-11-27

申请人： UCB, S.A.

发明人： LAMBERTY, Yves ,  MATAGNE, Alain ,  KLITGAARD, Henrik ,  WAEGEMANS, Tony

IPC分类号： A61K31/55 ,  A61K31/515 ,  A61K31/56 ,  A61K31/40 ,  A61P25/00

CPC分类号： A61K45/06 ,  A61K31/19 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/515 ,  A61K31/55 ,  A61K31/56 ,  Y10S514/922 ,  A61K2300/00

摘要： A use of (S)-(-)-α-ethyl-2-oxo-1-pyrrolidineacetamide for the manufacture of a medicament for treatment of particular diseases and new pharmaceutical compositions comprising (S)-(-)-α-ethyl-2-oxo-1-pyrrolidineacetamide.

摘要翻译： （S） - （ - ） - - - - 乙基-2-氧代-1-吡咯烷乙酰胺用于制备用于治疗特定疾病的药物的用途和包含（S） - （ - ） - 2-氧代-1-吡咯烷乙酰胺。