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    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    91.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2625524A2

    公开(公告)日：2013-08-14

    申请号：EP11831575.3

    申请日：2011-10-06

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  McPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James Patrick

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Beta-nerve growth factor, Interleukin-17A, Follitropin subunit beta, Collagenase 3, Follistatin, Vitamin D Binding Protein, Islet amyloid polypeptide, Insulin C-peptide, Complement Factor H, Gastric inhibitory polypeptide, Glucagon-like peptide 1, Glucagon, Involucrin, Type II cytoskeletal Keratin-1/Keratin-10, Type II cytoskeletal Keratin-6A/6B/6C, Osteocalcin, Lipopolysaccharide, Pancreatic prohormone, Peptide YY, Agouti-related protein, Ciliary neurotrophic factor, Appetite-regulating hormone, Transthyretin, Insulin receptor substrate 1, and NF-kappa-B inhibitor alpha as diagnostic and prognostic biomarker assays in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 特别地，本发明涉及使用检测选自以下的一种或多种生物标记的测定法：β-神经生长因子，白细胞介素-17A，促卵泡素亚基β，胶原酶3，卵泡抑素，维生素D结合蛋白，胰岛淀粉样多肽，胰岛素 C-肽，补体因子H，胃抑制性多肽，胰高血糖素样肽1，胰高血糖素，Involucrin，II型细胞骨架角蛋白-1 /角蛋白-10，II型细胞骨架角蛋白-6A / 6B / 6C，骨钙素，脂多糖，胰激素原 ，肽YY，刺鼠相关蛋白，睫状神经营养因子，食欲调节激素，转甲状腺素蛋白，胰岛素受体底物1和NF-κB抑制剂α作为肾损伤诊断和预后生物标志物测定。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    92.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2593794A2

    公开(公告)日：2013-05-22

    申请号：EP11807169.5

    申请日：2011-06-23

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  McPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

    IPC分类号： G01N33/543

    CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/60

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Alpha-2-HS-glycoprotein, Interleukin-9, Leukemia inhibitory factor, Macrophage colony-stimulating factor 1, Prolactin, and Stromal cell-derived factor 12 as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 特别地，本发明涉及使用一种或多种配置为检测选自由α-2-HS-糖蛋白，白细胞介素-9，白血病抑制因子，巨噬细胞集落刺激因子1，催乳素 和基质细胞衍生因子12作为肾损伤的诊断和预后生物标志物。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    94.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 有权
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2585825A1

    公开(公告)日：2013-05-01

    申请号：EP11798514.3

    申请日：2011-06-23

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  McPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

    IPC分类号： G01N33/48 ,  G01N33/53

    CPC分类号： G01N33/6893 ,  G01N33/573 ,  G01N33/74 ,  G01N33/92 ,  G01N2800/347 ,  G01N2800/60

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect Insulin-like growth factor-binding protein 4, and optionally further a kidney injury marker of Tumor necrosis factor receptor superfamily member 8, Alpha-Fetoprotein, Thyroxine-binding globulin, Prostate-specific antigen (free form), Apolipoprotein A, Apolipoprotein E, Thyrotropin subunit beta, Platelet-derived growth factor B/B dimer, C-C motif chemokine 7, C-C motif chemokine 26, Complement C4-B, Corticotropin, Interferon alpha-2, Interleukin-4 receptor alpha chain, , Insulin-like growth factor-binding protein 5, Interleukin 21, Interleukin 23 alpha subunit, Interleukin-28A, Interleukin-33, Lutropin subunit beta, Matrix Metalloproteinase-1, Neural cell adhesion molecule 1, Pigment epithelium-derived factor, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 3, and IgG4 as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 具体而言，本发明涉及使用一种或多种配置为检测选自肿瘤坏死因子受体超家族成员8，α-甲胎蛋白，甲状腺素 - 结合球蛋白，前列腺特异性抗原（游离形式 ），载脂蛋白A，载脂蛋白E，促甲状腺素亚基β，血小板衍生生长因子B / B二聚体，CC基序趋化因子7，CC基序趋化因子26，补体C4-B，促肾上腺皮质激素，干扰素α-2，白细胞介素-4受体α链 ，胰岛素样生长因子结合蛋白4，胰岛素样生长因子结合蛋白5，白细胞介素21，白细胞介素23α亚基，白细胞介素-28A，白细胞介素33，葫芦巴亚基β，基质金属蛋白酶-1，神经细胞粘附分子 1，色素上皮衍生因子，血管内皮生长因子受体2，血管内皮生长因子受体3和IgG4作为肾损伤诊断和预后生物标志物。