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1.发明授权
公开(公告)号：EP2265957B1
公开(公告)日：2013-07-24
申请号：EP09731279.7
申请日：2009-04-08
申请人： B.R.A.H.M.S GmbH
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/5754 , G01N2800/32
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公开(公告)号：EP2147316A2
公开(公告)日：2010-01-27
申请号：EP08758039.5
申请日：2008-05-08
发明人： BERGMANN, Andreas , STRUCK, Joachim
IPC分类号： G01N33/74
CPC分类号： G01N33/6893 , G01N33/74 , G01N2333/5754 , G01N2800/12 , G01N2800/122 , G01N2800/32 , G01N2800/324 , G01N2800/50 , G01N2800/52
摘要： The invention relates to a method for the diagnosis and/or risk stratification of cardiac diseases and diseases of the respiratory tract and lungs. According to said method, the free fragment N-terminal proEndothelin (NT-proET-1; AS 18-52 of the preproET according to fig. 1) or fragments and partial peptides thereof is or are determined.
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3.发明公开Verfahren zur Bestimmung der Bildung von Endothelinen zu Zwecken der medizinischen Diagnostik, sowie Antikörper und Kits für die Durchführung eines solchen Verfahrens 有权一种用于确定内皮素的形成用于医疗诊断的目的，以及抗体和试剂盒用于执行这样的方法的方法
公开(公告)号：EP1564558A1
公开(公告)日：2005-08-17
申请号：EP04003295.5
申请日：2004-02-13
IPC分类号： G01N33/74 , G01N33/68 , G01N33/574
CPC分类号： C07K16/00 , G01N33/57488 , G01N33/6893 , G01N33/74 , G01N2333/5754 , Y10S435/975
摘要： In vitro-Verfahren zur Bestimmung der Bildung von Endothelinen bei schweren Erkrankungen, insbesondere Herz-Kreislauf-Erkrankungen, Entzündungen, Sepsis und Krebs, in Vollblut, Plasma oder Serum eines menschlichen Patienten zu Zwecken der medizinischen Diagnostik, bei dem man relativ langlebige Peptidfragmente der prozessierten primären Präpro- bzw. Pro-Endotheline bestimmt, die weder das eigentliche biologisch aktive Endothelin noch dessen unmittelbaren Vorläufer big-Endothelin enthalten, insbesondere ein C-terminales Peptidfragment.
摘要翻译： 在体外测试，以确定在矿井的人全血或血浆或血清endolithins形成标识的发展endolethin-1和大endolethin -1。 preproendolethin-1的C-末端片段是确定性的开采其由抗体键合到肽识别。 的肽序列相匹配的93氨基酸范围到preproendolethin -1的212。 在生物流体中的确定是通过竞争性或夹心免疫测定，与仅特定于特定的肽片段的至少一个经标记的抗体工作。
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公开(公告)号：EP2438447B1
公开(公告)日：2015-02-18
申请号：EP10724303.2
申请日：2010-06-04
申请人： B.R.A.H.M.S GmbH
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/575 , G01N2333/5754 , G01N2333/58 , G01N2800/12 , G01N2800/26
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5.发明授权PRO-ENDOTHELIN-1 LEVELS FOR THE PREDICTION OF RISK OF TACHYARRHYTMIC EVENTS 有权PRO-内皮素-1镜事件的风险测定TACHYARRHYTHMISCHEN
公开(公告)号：EP2260307B1
公开(公告)日：2014-03-26
申请号：EP09727643.0
申请日：2009-04-03
申请人： B.R.A.H.M.S GmbH
CPC分类号： G01N33/74 , G01N33/6893 , G01N2333/5754 , G01N2800/326
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公开(公告)号：EP2267455A3
公开(公告)日：2012-01-04
申请号：EP10183988.4
申请日：2005-03-18
CPC分类号： G01N33/6893 , G01N33/6887 , G01N33/74 , G01N2333/5754 , G01N2333/58 , G01N2800/325
摘要： Provided are methods for predicting survival outcome of an individual suffering from congestive heart failure. In accordance with the method, a patient's survival outcome is determined by taking into consideration the levels of two markers in combination, the combination being more predictive of survival than either marker alone. The markers include endothelin, atrial natriurctic peptide and brain natriurctic peptide, their precursors and fragments thereof. Individuals with congestive heart failure identified as having increased risk of mortality using the methods of the invention are appropriately targeted for more aggressive therapy.
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公开(公告)号：EP2267456A3
公开(公告)日：2011-08-17
申请号：EP10184000.7
申请日：2005-03-18
CPC分类号： G01N33/6893 , G01N33/6887 , G01N33/74 , G01N2333/5754 , G01N2333/58 , G01N2800/325
摘要： Provided are methods for predicting survival outcome of an individual suffering from congestive heart failure. In accordance with the method, a patient's survival outcome is determined by taking into consideration the levels of two markers in combination, the combination being more predictive of survival than either marker alone. The markers include endothelin, atrial natriurctic peptide and brain natriurctic pcptidc, their precursors and fragments thereof. Individuals with congestive heart failure identified as having increased risk of mortality using the methods of the invention are appropriately targeted for more aggressive therapy.
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公开(公告)号：EP2267456A2
公开(公告)日：2010-12-29
申请号：EP10184000.7
申请日：2005-03-18
CPC分类号： G01N33/6893 , G01N33/6887 , G01N33/74 , G01N2333/5754 , G01N2333/58 , G01N2800/325
摘要： Provided are methods for predicting survival outcome of an individual suffering from congestive heart failure. In accordance with the method, a patient's survival outcome is determined by taking into consideration the levels of two markers in combination, the combination being more predictive of survival than either marker alone. The markers include endothelin, atrial natriurctic peptide and brain natriurctic pcptidc, their precursors and fragments thereof. Individuals with congestive heart failure identified as having increased risk of mortality using the methods of the invention are appropriately targeted for more aggressive therapy.
摘要翻译： 提供了用于预测患有充血性心力衰竭的个体的存活结果的方法。 根据该方法，通过考虑两种标志物组合的水平来确定患者的存活结果，该组合比单独的任一标志物更能预测存活。 标记物包括内皮素，心房三硝酸肽和脑钠三肽，它们的前体及其片段。 使用本发明的方法鉴定具有增加的死亡风险的充血性心力衰竭患者适合用于更积极的治疗。
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9.发明公开PRO-ENDOTHELIN-1 LEVELS FOR THE PREDICTION OF RISK OF TACHYARRHYTMIC EVENTS 有权PRO-内皮素-1镜事件的风险测定TACHYARRHYTHMISCHEN
公开(公告)号：EP2260307A1
公开(公告)日：2010-12-15
申请号：EP09727643.0
申请日：2009-04-03
申请人： B.R.A.H.M.S GmbH
CPC分类号： G01N33/74 , G01N33/6893 , G01N2333/5754 , G01N2800/326
摘要： The invention relates to in vitro methods for prognosis and risk-stratification for a patient having a cardiac disease as heart failure. The invention further relates to the use of such a method.
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10.发明公开Pro-endothelin-1 levels for the prediction of risk of tachyarrhytmic events 审中-公开Pro-Endothelin-1-Spiegelfürdie Risikobestimmung von tachyarrhthmischen Ereignissen
公开(公告)号：EP2107377A1
公开(公告)日：2009-10-07
申请号：EP08154109.6
申请日：2008-04-04
CPC分类号： G01N33/74 , G01N33/6893 , G01N2333/5754 , G01N2800/326
摘要： The invention relates to in vitro methods for prognosis and risk-stratification for a patient having a cardiac disease as heart failure. The invention further relates to the use of such a method.
摘要翻译： 本发明涉及具有心脏病作为心力衰竭的患者的预后和风险分层的体外方法。 本发明还涉及这种方法的使用。
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