-
公开(公告)号：EP3421499A1
公开(公告)日：2019-01-02
申请号：EP18188488.3
申请日：2011-03-10
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K16/30
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, hepatocellular cancer, colon cancer, pancreatic cancer, esophageal cancer, head & neck cancer, kidney cancer, in particular renal cell carcinoma, prostate cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid cancer, and the metastatic forms thereof. In one embodiment, the tumor disease is metastatic cancer in the lung.
-
公开(公告)号：EP2550296B1
公开(公告)日：2018-08-15
申请号：EP11708201.6
申请日：2011-03-10
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/462 , C07K16/464 , C07K2317/14 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C12N5/163 , C12N15/1138 , C12N2310/14
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, hepatocellular cancer, colon cancer, pancreatic cancer, esophageal cancer, head & neck cancer, kidney cancer, in particular renal cell carcinoma, prostate cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid cancer, and the metastatic forms thereof. In one embodiment, the tumor disease is metastatic cancer in the lung.
-
公开(公告)号：EP3305813A1
公开(公告)日：2018-04-11
申请号：EP17189247.4
申请日：2010-11-11
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael
IPC分类号： C07K16/28 , C07K14/705 , A61P35/00 , A61K39/395 , C07K16/30 , A61K39/00
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了用作治疗和/或预防与表达紧密连接蛋白-6（CLDN6）的细胞有关的疾病的抗体，所述疾病包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌 ，皮肤癌，恶性黑色素瘤，头颈部癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，宫颈癌，睾丸癌和子宫癌。
-
94.发明公开METHODS AND COMPOSITIONS FOR PREDICTION OF THERAPEUTIC EFFICACY OF CANCER TREATMENTS AND CANCER PROGNOSIS 审中-公开预测癌症治疗和癌症预后的疗效的方法和组合物
公开(公告)号：EP3283644A1
公开(公告)日：2018-02-21
申请号：EP16717324.4
申请日：2016-04-13
申请人： Ganymed Pharmaceuticals GmbH , Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg Universität Mainz gGmbH (TRON)
发明人： SAHIN, Ugur , TÜRECI, Özlem , MAURUS, Daniel
IPC分类号： C12Q1/68
摘要： The invention generally relates to methods and compositions for the prediction of therapeutic efficacy of cancer treatments and the prognosis of cancer. The invention discloses markers that are associated with favorable and unfavorable outcomes, respectively, in certain cancer treatments and are useful as prognostic markers for cancer. Methods involving these markers are disclosed for predicting cancer therapy benefit and prognosing clinical outcome for cancer patients.
-
95.发明公开
公开(公告)号：EP3254695A1
公开(公告)日：2017-12-13
申请号：EP17171169.0
申请日：2013-05-21
申请人： GANYMED Pharmaceuticals AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Stefan, Denis , UTSCH, Magdalena, Jadwiga , HEINZ, Cornelia, Adriana, Maria , STADLER, Christiane, Regina
IPC分类号： A61K39/395 , C07K16/30 , A61K45/06
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
-
公开(公告)号：EP2342234B1
公开(公告)日：2017-11-15
申请号：EP09778564.6
申请日：2009-09-16
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/34 , C07K2317/73
-
公开(公告)号：EP3213765A2
公开(公告)日：2017-09-06
申请号：EP17165403.1
申请日：2011-09-19
申请人： BioNTech Cell & Gene Therapies GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , SIMON, Petra , OMOKOKO, Tana
IPC分类号： A61K39/00 , C07K14/705 , C07K14/47 , C07K14/045
CPC分类号： A61K39/0011 , A61K39/12 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/7051 , C12N5/0636 , C12N9/16 , C12N15/85 , C12N2510/00 , C12N2710/16134 , C12Y301/03048 , G01N33/5017 , G01N2333/916
摘要： The present invention relates to efficient methods for providing antigen- specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
-
98.发明公开METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER 审中-公开VERFAHREN UND ZUSAMMENSETZUNGEN ZUR DIAGNOSE UND BEHANDLUNG VON KREBS
公开(公告)号：EP3170511A1
公开(公告)日：2017-05-24
申请号：EP16202946.6
申请日：2010-02-18
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael
IPC分类号： A61K39/395
CPC分类号： C07K16/3046 , A61K2039/505 , C07K2317/34 , G01N33/57419 , G01N33/57446
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of colorectal, in particular colonic, and gastric tumor tissues and colorectal, in particular colonic, and gastric tissues, and which represent targets for therapy or diagnosis of such tumor diseases in a subject.
摘要翻译： 本发明涉及特异性结肠直肠，特别是结肠和胃肿瘤组织和结肠直肠特别是结肠和胃组织的特征的核酸和氨基酸序列的鉴定，其代表治疗或诊断这种肿瘤的靶点 一个科目的疾病
-
公开(公告)号：EP2499161A1
公开(公告)日：2012-09-19
申请号：EP10778877.0
申请日：2010-11-11
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael
IPC分类号： C07K16/28 , C07K14/705 , A61P35/00 , A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达紧密连接蛋白-6（CLDN6）的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌 ，皮肤癌，恶性黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。
-
100.发明公开MONOCLONAL ANTIBODIES FOR TREATMENT OF CANCER 有权MONOKLONALE ANTI-GT468ANTIKÖRPERZUR BEHANDLUNG VON KREBS
公开(公告)号：EP2342234A2
公开(公告)日：2011-07-13
申请号：EP09778564.6
申请日：2009-09-16
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/34 , C07K2317/73
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast Cancer, lung Cancer, gastric Cancer, ovarian Cancer, hepatocellular Cancer, colon Cancer, pancreatic Cancer, esophageal Cancer, head & neck Cancer, kidney Cancer, in particular renal cell Carcinoma, prostate Cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid Cancer, and the metastatic forms thereof. In one embodiment, the rumor disease is metastatic cancer in the lung.
摘要翻译： 本发明提供了用作治疗和/或预防与表达GT468的细胞相关疾病（包括肿瘤相关疾病如乳腺癌，肺癌，胃癌，卵巢癌和肝细胞癌）的治疗剂的抗体。
-
-
-
-
-
-
-
-
-
搜索结果
109 条记录 (耗时 0.052 秒)
