公开(公告)号：EP4416292A2

公开(公告)日：2024-08-21

申请号：EP22882061.9

申请日：2022-10-14

申请人： Arsenal Biosciences, Inc.

发明人： WILLIAMS, Jasper ,  NGUYEN, Michelle ,  YAO, Anzhi ,  SANTORO, Stephen ,  COOPER, Aaron ,  GAGNON, John ,  LITTERMAN, Adam ,  KHAN, Omar ,  BEZMAN, Natalie ,  HARRIS, Katherine ,  MALIK CHAUDHRY, Harbani Kaur ,  ALLEN, Nicole

IPC分类号： C12N15/62 ,  C07K14/705 ,  C12N5/16 ,  C12N9/22 ,  C12N15/113

CPC分类号： A61K48/005 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464468 ,  A61K2239/5920230501 ,  A61K2239/2820230501 ,  A61K39/464463 ,  A61K39/464412 ,  C12N2740/1604320130101 ,  C07K14/7051 ,  C07K14/70578 ,  C07K2319/0020130101 ,  C12N15/62 ,  C12N9/16 ,  C12Y301/03048 ,  C07K14/4702 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2320/3120130101

公开(公告)号：EP3189333A4

公开(公告)日：2018-04-18

申请号：EP15831971

申请日：2015-08-13

申请人： AGENCY FOR SCIENCE TECH AND RESEARCH

发明人： ZENG QI

IPC分类号： G01N33/574 ,  A61K39/00 ,  A61K39/395 ,  C07K16/40

CPC分类号： G01N33/5748 ,  A61K2039/505 ,  C07K16/40 ,  C12Y301/03048 ,  G01N33/57488 ,  G01N2333/82 ,  G01N2333/916

摘要： The data provided herewith show that, biomarkers found within the cells of a tumor or cancer may also be present at adequate levels within the patient's urine to enable detection. Method of diagnosis, patient selection and treatment are provided, along with kits and devices.

公开(公告)号：EP2839006B1

公开(公告)日：2018-01-03

申请号：EP13777683.7

申请日：2013-04-22

申请人： Ionis Pharmaceuticals, Inc.

发明人： FREIER, Susan, M. ,  SWAYZE, Eric, E.

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/343 ,  C12N2310/3525 ,  C12N2320/51 ,  C12Y301/03016 ,  C12Y301/03048 ,  C12Y301/03067

摘要： The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.

公开(公告)号：EP3011332A4

公开(公告)日：2017-04-05

申请号：EP14814488

申请日：2014-06-17

申请人： CHU SAINTE-JUSTINE

发明人： MOREAU ALAIN ,  AKOUME NDONG MARIE-YVONNE ,  ELBAKRY MOHAMED

IPC分类号： G01N33/68 ,  A61K31/135 ,  A61K31/519 ,  A61K31/713 ,  C12Q1/42 ,  C12Q1/48 ,  G01N33/50

CPC分类号： G01N33/573 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q1/42 ,  C12Q1/485 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Y207/01068 ,  C12Y301/03048 ,  G01N33/5047 ,  G01N33/5091 ,  G01N33/6893 ,  G01N2333/912 ,  G01N2333/91215 ,  G01N2333/916 ,  G01N2800/10 ,  G01N2800/50 ,  G01N2800/56

摘要： Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1γ tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1γ expression and/or activity.

公开(公告)号：EP2922394B1

公开(公告)日：2017-02-22

申请号：EP14781783.7

申请日：2014-09-23

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MURPHY, Andrew J. ,  THURSTON, O. Gavin ,  VARGHESE, Bindu ,  GURER, Cagan

IPC分类号： A01K67/027 ,  C12N15/90 ,  C07K14/705

CPC分类号： A01K67/0278 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2217/054 ,  A01K2217/072 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/0331 ,  A01K2267/0381 ,  A01K2267/0387 ,  A61K49/0008 ,  C07K14/70503 ,  C07K14/70596 ,  C07K16/2809 ,  C07K16/2887 ,  C07K2317/31 ,  C07K2319/00 ,  C12N9/16 ,  C12N15/8509 ,  C12N15/89 ,  C12N15/902 ,  C12N15/907 ,  C12N2015/8518 ,  C12N2015/8527 ,  C12N2015/8572 ,  C12N2800/30 ,  C12Y301/03048 ,  G01N33/5011 ,  G01N33/5088 ,  G01N2500/04 ,  G01N2500/10

公开(公告)号：EP2536420A4

公开(公告)日：2016-02-24

申请号：EP11745260

申请日：2011-02-17

申请人： UNIV COLUMBIA

发明人： PARSONS RAMON

IPC分类号： A61K38/02 ,  A61K38/00 ,  A61K47/48 ,  C12N9/16

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K47/64 ,  A61K47/645 ,  C07K14/4746 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/10 ,  C12N9/16 ,  C12Y301/03048

摘要： A composition for delivering cargo molecules across biological membranes is provided comprising (i) a peptide comprising consecutive amino acid residues having the sequence set forth in SEQ ID NO 1 for the transport of a cargo molecule across a biological membrane and (ii) the cargo molecule, wherein the cargo molecule is not a peptide comprising amino acid residues having the sequence set forth in SEQ ID NO 4. Methods of delivering cargo molecules across biological membranes are also provided. Methods of treating a tumor, cancer, a metabolic disorder, and a cardiovascular disorder are also provided.

公开(公告)号：EP2841086A4

公开(公告)日：2015-12-02

申请号：EP13775928

申请日：2013-04-09

申请人： UNIV CASE WESTERN RESERVE

发明人： LANG BRADLEY T ,  CREGG JARED M ,  SILVER JERRY ,  WANG YI-LAN

IPC分类号： A61K38/17 ,  A61K38/16 ,  A61K38/46 ,  A61P35/00

CPC分类号： A61K38/465 ,  C12Y301/03048

摘要： A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.

摘要翻译： 抑制和/或降低由蛋白多糖诱导的受试者细胞中白细胞共同抗原相关（LAR）家族磷酸酶的活性，信号传导和/或功能的方法包括向细胞施用抑制一种或多种 更多的LAR家族磷酸酶的催化​​活性，信号和功能，而不抑制蛋白聚糖结合或激活LAR家族磷酸酶。

公开(公告)号：EP2618835A1

公开(公告)日：2013-07-31

申请号：EP11761508.8

申请日：2011-09-19

申请人： Biontech AG ,  Universitätsmedizin der Johannes Gutenberg-Universität Mainz ,  TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH

发明人： SAHIN, Ugur ,  TÜRECI, Özlem ,  SIMON, Petra ,  OMOKOKO, Tana

IPC分类号： A61K39/00 ,  C07K14/705 ,  C07K14/47 ,  C07K14/045

CPC分类号： A61K39/0011 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/7051 ,  C12N5/0636 ,  C12N9/16 ,  C12N15/85 ,  C12N2510/00 ,  C12N2710/16134 ,  C12Y301/03048 ,  G01N33/5017 ,  G01N2333/916

摘要： The present invention relates to efficient methods for providing antigen- specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.

摘要翻译： 本发明涉及提供抗原特异性淋巴样细胞的有效方法。 这些淋巴样细胞可用于提供具有确定的MHC限制的抗原特异性T细胞受体并鉴定免疫相关的T细胞表位。 此外，本发明涉及抗原特异性T细胞受体和T细胞表位及其在免疫治疗中的用途。

公开(公告)号：EP2552451A1

公开(公告)日：2013-02-06

申请号：EP11712218.4

申请日：2011-03-28

申请人： Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research

发明人： BENTIRES-ALJ, Mohamed ,  ACETO, Nicola

IPC分类号： A61K31/65 ,  A61K38/00 ,  A61K39/00 ,  A61P35/00

CPC分类号： A61K31/713 ,  C12N9/16 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/531 ,  C12Y301/03048

摘要： The present invention relates to a method for treating cancer in a subject by killing tumor initiating cells, inducing differentiation of tumor initiating cells into differentiated cells or blocking the conversion of differentiated tumor cells into tumor initiating cells, which method comprises the step of administering to said subject a therapeutically effective amount of a modulator of the protein tyrosine phosphatase, non-receptor type 11 (PTPN11) gene or of its gene product (Shp2). The present invention also provides a siRNA decreasing or silencing the expression of protein tyrosine phosphatase, non-receptor type 11 (PTPN11) and/or an antibody specifically binding to protein tyrosine phosphatase, non-receptor type 11 (PTPN11), for use as a medicament to treat cancer according to the methods described herein. The present invention also provides a peptide comprising an amino acid sequence specifically recognized by protein tyrosine phosphatase, non-receptor type 11 (PTPN11), for use as a medicament to treat cancer according to the methods described herein above.

摘要翻译： 本发明涉及通过杀死肿瘤起始细胞，诱导肿瘤起始细胞分化成分化细胞或阻断分化肿瘤细胞转化成肿瘤起始细胞来治疗受试者的癌症的方法，该方法包括给所述 患有治疗有效量的蛋白酪氨酸磷酸酶，非受体型11（PTPN11）基因或其基因产物（Shp2）的调节剂。 本发明还提供降低或沉默蛋白质酪氨酸磷酸酶，非受体型11（PTPN11）和/或特异性结合蛋白酪氨酸磷酸酶，非受体型11（PTPN11）的抗体的表达的siRNA，用作 根据本文所述的方法治疗癌症的药物。 本发明还提供了包含蛋白酪氨酸磷酸酶，非受体型11型（PTPN11）特异性识别的氨基酸序列的肽，其用作根据上述方法治疗癌症的药物。

公开(公告)号：EP2408821A4

公开(公告)日：2012-03-07

申请号：EP10749086

申请日：2010-02-05

申请人： VITALIANO FRANCO ,  VITALIANO GORDANA

发明人： VITALIANO FRANCO ,  VITALIANO GORDANA

IPC分类号： C07K17/00 ,  A61K9/50 ,  A61K9/51

CPC分类号： A61K9/5169 ,  A61K38/17 ,  A61K38/1709 ,  A61K38/45 ,  A61K38/465 ,  A61K45/06 ,  A61K47/42 ,  A61K47/62 ,  A61K47/6949 ,  A61K49/0004 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  C07K14/47 ,  C12Y205/01018 ,  C12Y301/03048 ,  G01N33/15 ,  G01N35/00722 ,  G06N5/02 ,  Y10S977/773 ,  Y10S977/795 ,  Y10S977/904 ,  Y10S977/906 ,  Y10S977/919 ,  Y10S977/923 ,  Y10S977/932

摘要： The invention relates generally to the field of nanoparticles, and more specifically, in one embodiment, to bio-nanoparticle elements formed from materials comprised of self-assembling protein molecules, which are capable of coating one or more type of elements. In another invention embodiment, the invention relates to a protein that coats one or more elements in order to modify or improve one or more characteristic of the element, including, but not limited to, stability, rigidity, or functionality of the element that is coated with the instant invention.

摘要翻译： 合适的实施方案中的本发明涉及使用纯化的非笼状网格蛋白，用于协助药物发现和开发。 在一个方面，由全部或部分一个或多个蛋白质序列组成的分离的，合成的和/或重组的氨基酸残基全部或部分形成的工具组合物形成用于进行各种元件和活性的一种或多种类型的工具 的药物发现与发展。