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公开(公告)号：EP1508047B1
公开(公告)日：2008-08-06
申请号：EP03735383.6
申请日：2003-05-14
CPC分类号： C40B30/04 , A61K38/1709 , A61K39/0011 , C07K14/4748
摘要： The invention relates to a method for identifying immunoreactive peptides. According to said method, a sample consisting of tumorous and corresponding healthy tissue is first prepared, the tumour-specific expression profile is subsequently determined and antigenic peptides are isolated from the tumorous tissue and analysed. The respective data that has been obtained is then matched and peptides are identified on the basis of said matched data.
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公开(公告)号：EP1508047A2
公开(公告)日：2005-02-23
申请号：EP03735383.6
申请日：2003-05-14
CPC分类号： C40B30/04 , A61K38/1709 , A61K39/0011 , C07K14/4748
摘要： The invention relates to a method for identifying immunoreactive peptides. According to said method, a sample consisting of tumorous and corresponding healthy tissue is first prepared, the tumour-specific expression profile is subsequently determined and antigenic peptides are isolated from the tumorous tissue and analysed. The respective data that has been obtained is then matched and peptides are identified on the basis of said matched data.
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公开(公告)号：EP4014043A1
公开(公告)日：2022-06-22
申请号：EP20757269.4
申请日：2020-08-12
发明人： SCHUSTER, Heiko , HUTT, Meike , WEINSCHENK, Toni , BUNK, Sebastian , SCHOOR, Oliver , BACKERT, Linus , HOFMANN, Martin , FRITSCHE, Jens , UNVERDORBEN, Felix , SCHIMMACK, Gisela , SCHWÖRER, Florian
IPC分类号： G01N33/569
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94.发明公开
公开(公告)号：EP3919507A2
公开(公告)日：2021-12-08
申请号：EP21177102.7
申请日：2016-06-29
发明人： MAHR, Andrea , WEINSCHENK, Toni , HÖRZER, Helen , SCHOOR, Oliver , FRITSCHE, Jens , SINGH, Harpreet
摘要： Provided is a peptide of up to 30 amino acids comprising the amino acid sequence of SEQ ID NO: 217 or one of SEQ ID NOs: 1 to 10, 12 to 216 and 218 to 640. Provided are inter alia also a nucleic acid encoding such peptide, a host cell comprising the same, a T-cell receptor reactive with such peptide and an activated T lymphocyte recognizing a cell which presents such peptide. Provided is also the use of any of the above in cancer treatment.
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95.发明公开
公开(公告)号：EP3875467A3
公开(公告)日：2021-12-08
申请号：EP21162594.2
申请日：2016-11-29
发明人： MAHR, Andrea , WEINSCHENK, Toni , HÖRZER, Helen , SCHOOR, Oliver , FRITSCHE, Jens , SINGH, Harpreet
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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96.发明公开
公开(公告)号：EP3829720A1
公开(公告)日：2021-06-09
申请号：EP19748790.3
申请日：2019-07-30
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97.发明公开
公开(公告)号：EP3760225A3
公开(公告)日：2021-03-24
申请号：EP20179381.7
申请日：2016-04-22
发明人： MAHR, Andrea , WEINSCHENK, Toni , SCHOOR, Oliver , FRITSCHE, Jens , SINGH, Harpreet , WAGNER, Claudia , LEIBOLD, Julia , SONG, Colette
摘要： The present invention relates to peptides, especially the peptide of SEQ ID Nos. 24, 26 and 159, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor- associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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98.发明公开
公开(公告)号：EP3738606A1
公开(公告)日：2020-11-18
申请号：EP20179386.6
申请日：2011-03-15
摘要： The present invention relates to peptides, in particular the peptide of SEQ ID No. 88, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses.
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99.发明公开
公开(公告)号：EP3715357A1
公开(公告)日：2020-09-30
申请号：EP20172206.3
申请日：2015-12-16
发明人： WEINSCHENK, Toni , MAHR, Andrea , FRITSCHE, Jens , MÜLLER, Phillip , WIEBE, Anita , MISSEL, Sarah
摘要： The current invention relates to a pharmaceutical composition comprising a peptide of the sequence according to SEQ ID No. 303 together with at least one suitable carrier and/or excipient for use in the treatment of Hepatocellular carcinoma cancer (HCC).
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100.发明授权
公开(公告)号：EP3317296B1
公开(公告)日：2020-09-30
申请号：EP16733523.1
申请日：2016-06-29
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