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566 条记录 (耗时 0.027 秒)

    DRUG DELIVERY DEVICE COMPRISING A DUAL CHAMBER RESERVOIR
    91.
    发明公开
    DRUG DELIVERY DEVICE COMPRISING A DUAL CHAMBER RESERVOIR 审中-公开
    DEVICE毒品与两室集装箱提货

    公开(公告)号：EP1171194A1

    公开(公告)日：2002-01-16

    申请号：EP00922160.7

    申请日：2000-04-13

    申请人： JOHNSON & JOHNSON CONSUMER COMPANIES, INC.

    发明人： SUN, Ying ,  OAKESON, Ralph, W. ,  WISNIEWSKI, Stephen, J. ,  WANG, Jonas, C., T.

    IPC分类号： A61N1/30 ,  A61N1/32

    CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/0448 ,  A61N1/325

    摘要： The present invention relates to an apparatus (100) for the delivery of an active agent through a body surface (e.g., the skin or mucosa) of a mammal comprising: a housing with a delivery orifice (134) through the housing (102); an active agent reservoir (120) within the housing for containing the active agent where the active agent reservoir is in communication with the delivery orifice; a fluid reservoir (110) within the housing for containing a fluid; and a semi-permeable membrane (108) in communication with the active agent reservoir and the fluid reservoir for permitting the movement of fluid between the active agent reservoir and the fluid reservoir and substantially preventing the movement of the active agent between the active agent reservoir and the fluid reservoir.

    Method of preparing a water soluble film
    94.
    发明公开
    Method of preparing a water soluble film 审中-公开
    Verfahren zur Herstellung vonwasserlöslichenFilmen

    公开(公告)号：EP1110546A1

    公开(公告)日：2001-06-27

    申请号：EP00311610.0

    申请日：2000-12-22

    申请人： Johnson & Johnson Consumer Companies, Inc.

    发明人： Lin, Shun Y. ,  Patel, Kalpana J. ,  Link, Martin ,  Kang, Maria L.

    IPC分类号： A61K9/70 ,  A61K9/00

    CPC分类号： A61K9/7007 ,  A61K9/0034

    摘要： The present invention provides a method of preparing a water soluble film. The method comprises (a) preparing a solution comprising a film former, a water soluble plasticizer, a pharmaceutically active agent, and a solvent; (b) drying the solution at a temperature of from about 50 to about 100° C to form a film; and (c) curing the film at a temperature of from about 15 to about 60° C and at a relative humidity of at least about 30%. The film former is a polyacrylic acid, cellulose derivatives, polyethylene oxide, polyvinyl alcohol, or any combination of any of the foregoing. The water soluble plasticizer contains at least one of a hydroxyl, amido, or amino group and has a boiling point greater than about 150° C. The water soluble film of the present invention may be incorporated into vaginal devices, such as tampons and applicators. This method produces a uniform and homogeneous film which is more flexible and drips less than prior water soluble films, especially those incorporated into vaginal dosage forms. As a result, the film is less irritating. Furthermore, unlike most prior art water soluble films, the film may be shaped to provide a larger contact area within a body cavity, such as the vagina, in order to increase drug delivery. The film is also non-messy.

    摘要翻译： 本发明提供了制备水溶性薄膜的方法。 该方法包括（a）制备包含成膜剂，水溶性增塑剂，药物活性剂和溶剂的溶液; （b）在约50至约100℃的温度下干燥溶液以形成膜; 和（c）在约15至约60℃的温度和至少约30％的相对湿度下固化该膜。 成膜剂是聚丙烯酸，纤维素衍生物，聚环氧乙烷，聚乙烯醇，或任何上述物质的组合。 水溶性增塑剂含有羟基，酰胺基或氨基中的至少一种，并且具有大于约150℃的沸点。本发明的水溶性薄膜可以并入阴道装置如棉塞和涂抹器中。 该方法产生均匀且均匀的膜，其比现有的水溶性薄膜，特别是并入阴道剂型更为柔软并且滴下。 因此，这部电影不那么刺激。 此外，与大多数现有技术的水溶性膜不同，膜可以被成形为在体腔（例如阴道）内提供更大的接触面积，以增加药物递送。 这部电影也是不乱的。

    Controlled release composition comprising a sustained release layer and a fast release layer
    95.
    发明公开
    Controlled release composition comprising a sustained release layer and a fast release layer 有权
    组合物对于活性成分的受控释放包括延迟feisetzende层和快速释放层

    公开(公告)号：EP1110541A1

    公开(公告)日：2001-06-27

    申请号：EP00311631.6

    申请日：2000-12-22

    申请人： JOHNSON & JOHNSON CONSUMER COMPANIES, INC.

    发明人： Lin, Shun Y ,  Wearley, Lorraine L. ,  Gole, Dilip J. ,  Posage, Gary W. ,  Wilkinson, Paul K.

    IPC分类号： A61K9/19

    CPC分类号： A61K9/2095 ,  A61K9/0034 ,  A61K9/209

    摘要： The present invention provides a composition comprising a sustained release layer and a fast release layer. The sustained release layer comprises a water-soluble polymer and a first pharmaceutically active agent. The fast release layer comprises a matrix forming agent and a second pharmaceutically active agent. Generally, the composition provides fast and sustained (or controlled) release of a pharmaceutically active agent for at least 6 hours and preferably for at least 1 to 3 days. The composition may be incorporated into a dosage unit form, such as a vaginal insert. The compositions are prepared by freeze-drying.

    摘要翻译： 本发明提供的组合物包含缓释层和近释放层。 持续释放层包含一种水溶性聚合物和一种第一药物活性剂。 释放层几乎包含基质形成剂和第二药物活性剂。 通常，该组合物提供至少6小时药物活性剂的快速和持续（或受控）释放，并且优选为至少1至3天。 该组合物可以被合并到一个剂量单位形式，搜索作为阴道插入物。 的组合物是通过冷冻干燥制备。