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    Monosaccharide derivatives
    91.
    发明公开
    Monosaccharide derivatives 审中-公开
    Monosaccharidderivate

    公开(公告)号：EP1864992A2

    公开(公告)日：2007-12-12

    申请号：EP07010703.2

    申请日：2007-05-30

    申请人： RANBAXY LABORATORIES, LTD.

    发明人： Verma, Ashwani Kumar ,  Malhotra, Sanjay ,  Dharmarajan, Sankaranaryanan ,  Ray, Abhijit ,  Shirumalla, Rajkumar

    IPC分类号： C07H13/12 ,  C07H9/04 ,  A61K31/7028 ,  A61P37/02

    CPC分类号： C07H13/12 ,  C07H9/04

    摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinids and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

    摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒症和过敏性鼻炎。 包含本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏 还提供了使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

    MONOSACCHARIDE DERIVATIVES AS ANTI-INFLAMMATORY AND/OR ANTI-CANCER AGENTS
    92.
    发明公开
    MONOSACCHARIDE DERIVATIVES AS ANTI-INFLAMMATORY AND/OR ANTI-CANCER AGENTS 审中-公开
    Monosaccharidderivate alsEntzündungshemmendeund / oder Anti-Tumor Agentien

    公开(公告)号：EP1842855A2

    公开(公告)日：2007-10-10

    申请号：EP07105121.3

    申请日：2007-03-28

    申请人： Ranbaxy Laboratories Limited

    发明人： Sattigeri, Viswajanani Jitendra ,  Arora, Sudershan K. ,  Salman, Mohammad ,  Palle, Venkata P. ,  Mukherji, Ashis ,  Verma, Ashwani Kumar ,  Malhotra, Sanjay ,  Dharmarahan, Sankaranarayanan ,  Ray, Abhijit ,  Shirumalla, Raj Kumar

    IPC分类号： C07H9/04 ,  C07H15/00 ,  C07H3/02 ,  A61K31/70 ,  A61K31/7004 ,  A61K31/7028 ,  A61K31/7042 ,  A61P37/00 ,  A61P35/00 ,  A61P17/00 ,  A61P11/06

    CPC分类号： C07H9/04 ,  C07H3/02 ,  C07H15/00

    摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type 1 diabetes, psoriasis, allograft rejection, inflammatory bowel disease, Ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

    摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文中的化合物障碍可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮， 动脉粥样硬化，癌症，瘙痒症和过敏性鼻炎。 包含本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，1型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性 还提供了使用这些化合物的鼻炎和其它炎性和/或自身免疫性疾病。

    NEW COMPOSITIONS
    94.
    发明公开
    NEW COMPOSITIONS 审中-公开
    新作品

    公开(公告)号：EP1765363A2

    公开(公告)日：2007-03-28

    申请号：EP05757818.9

    申请日：2005-07-14

    申请人： GLUCOGENE MEDICAL HFM AB

    发明人： ELLERVIK, Ulf ,  FRANSSON, Lars-Åke ,  BELTING, Mattias, Nils, Henry ,  MANI, Katrin

    IPC分类号： A61K31/7028

    CPC分类号： A61K45/06 ,  A61K31/7028 ,  A61K2300/00

    摘要： The invention relates to pharmaceutical composition comprising a) at least one 2-A-aryl-4-A-galactosyl-xylopyranoside derivative of formula I : (I), wherein the R1 groups are the same or different and independently selected from NY1Y2 and OY; Y, Y1 and Y2 are independently selected from H, alkyl, C(O)aryl, CH2aryl, C(O)alkyl, C(O)Oalkyl and C(O)Oalkenyl (wherein alkyl and alkenyl are as defined in the description); R2 is a galactopyranosyl or a galactopyranosyl derived mono-, di- or trisaccharide moiety as defined in the description; A is O, S, NH or CH2; B is selected from naphthyl, naphthylalkyl, antracenyl, antracenylalkyl or biphenyl, substituted with one or more substituents independently selected from F, C1, Br, I, NO2, CF3, COOH, NY1Y2 and OY; in combination with b) non-xylose compounds chosen from at least one polyamine synthesis inhibitor (e.g. α-difluoromethylornithine, DFMO) and at least one nitric oxide donor (e.g. spermineNONOate) or stimulator of nitric oxide synthesis or inducer of nitric oxide release from S-nitrosothiols, and optionally (an) other anti-tumour agent(s). The invention also relates to new compounds of formula I, and to use of the compounds and compositions in the manufacture of medicaments for the treatment of proliferative diseases, including various forms of cancer.

    EPIMEREDI GLYCOSIDE A, THE FORMULATION CONTAINING THEREOF AND THEIR PREPARATION METHOD
    98.
    发明公开
    EPIMEREDI GLYCOSIDE A, THE FORMULATION CONTAINING THEREOF AND THEIR PREPARATION METHOD 有权
    EPIMEREDI-GLYCOSID-A，DIESES ENTHALTENDE FORMULIERUNG UND VERFAHREN ZU DEREN HERSTELLUNG

    公开(公告)号：EP1681296A1

    公开(公告)日：2006-07-19

    申请号：EP04762203.0

    申请日：2004-09-20

    申请人： Shanghai Yao Gang Biological Technology Co., Ltd.

    发明人： HUANG, Huan

    IPC分类号： C07H15/18 ,  A61K31/70 ,  A61K31/7028 ,  A61K36/18 ,  A61P3/00 ,  A61P15/02 ,  A61P15/08 ,  A61P15/12 ,  A61P19/10

    CPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K36/53 ,  C07H1/08 ,  C07H15/18

    摘要： The invention relates to Epimeredinoside A and its structure as shown in Fig. I, and the preparation methods of pharmaceutics made from the Epimeredi indica root extract containing Epimeredinoside A. It includes all kinds of oral pharmaceutics made up of the Epimeredi indica root extract and pharmaceutical adjuvants. The root extract is the extracta sicca prepared by extracting water and concentrating the Epimeredi indica root to contain 0.10 % to 1.50 % of Epimeredinoside A. The invention, pharmaceutical preparations of Epimeredi indica root extract, DOES NOT contain any hormones. NO progesterone has to be taken in to prevent the side effects of using this drug. The pharmaceutical preparation has doubtless clinical effects and is stable, controllable and safe, thereby being especially compatible for the female menopause.

    摘要翻译： 本发明涉及视神经酰胺A及其结构，如图1所示。 I，以及由Epimeredinoide A制成的Epimeredi indica根提取物的制剂制备方法。它包括由Epimeredi indica根提取物和药物佐剂组成的各种口服药物。 根提取物是通过提取水并将Epimeredi a根浓缩成含有0.10％至1.50％的Epimedinoside A制备的提取物。本发明是Epimeredi indica根提取物的药物制剂，不含任何激素。 不要服用孕酮，以防止使用这种药物的副作用。 该药物制剂无疑具有临床效果，稳定，可控和安全，因此与女性绝经尤其相容。