公开(公告)号：EP0286242A3

公开(公告)日：1989-08-09

申请号：EP88302151.1

申请日：1988-03-11

申请人： GLAXO GROUP LIMITED

发明人： Skidmore, Ian Frederick ,  Finch, Harry ,  Mitchell, William Leonard ,  Naylor, Alan ,  Lunts, Lawrence Henry ,  Hartley, David

IPC分类号： C07C93/08 ,  C07C149/32 ,  C07C143/75 ,  C07C127/17 ,  C07C103/76 ,  C07D213/65 ,  C07D215/52 ,  A61K31/10 ,  A61K31/135 ,  A61K31/165

CPC分类号： C07D213/30 ,  C07D213/32 ,  C07D213/63

摘要： This invention relates to compounds of the general formula (I)
and physiologically acceptable salts and solvates thereof where Ar represents
where
R 3 is a bond or a straight or branched C 1 2 alkylene group, R 4 is a hydroxy group or a group R 5 NH-where R 5 represents a group CH 3 SO 2 -, HCO-or NH 2 CO-,
where R 6 is a chlorine atom or the group F 3 C-,
k represents an integer from 1 to 8, m represents zero or an integer from 2 to 7 and n represents an integer from 2 to 7 with the proviso that the sum total of k. m and n is 4 to 12; R 1 and R 2 each represents a hydrogen atom or a methyl or ethyl group with the proviso that the sum total of carbon atoms in R 1 and R 2 is not more than 2; R 30 represents hydrogen or C 12 alkyl; X represents an oxygen or sulphur atom: and Y and Q may each represent a bond or an oxygen or sulphur atom with the provisos that at least one of Y and Q represents an oxygen or sulphur atom and when Y is a bond m is zero, or when Y represents an oxygen or sulphur atom m is an integer from 2 to 7: P represents a phenyl group otionally substituted by one or more substituents selected from halogen atoms, or the groups C 1 3 alkyl, C 1 3 alkoxy, hydroxy, -CH 2 OH-, -(CH 2 ) 2 OH, -CO 2 H. -CO 2 CH 3 , ·CO 2 (CH 2 )- 2 CH 3 , -R 7 , COR 7 , -NHCOR s and ·NR 9 SO 2 R 10 ; where R 7 represents an amino, aminoC 1 3 alkyl, aminoC, 3 dialkyl, pyrrolidino. piperidino. hexamethyleneimino, piperazino, N-methylpiperazino or morpholino group; R 8 represents a hydrogen atom or a C, 4 alkyl, C, 4 alkoxy, phenyl or amino group; R 9 represents a hydrogen atom or a methyl group; R 10 represents a methyl, phenyl, amino or dimethylamino group;
or P represents a pyridyl group optionally substituted by one or two substitutents selected from halogen atoms or hydroxy, C, 3 alkyl and C 1 3 alkoxy groups. The compounds have a stimulant action at β 2 -adrenoreceptors and are useful, in particular, in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.

公开(公告)号：EP0112776A3

公开(公告)日：1984-09-12

申请号：EP83402501

申请日：1983-12-21

申请人： RHONE-POULENC SANTE

发明人： Dubroeucq, Marie-Christine ,  Le Fur, Gérard ,  Renault, Christian

IPC分类号： A61K31/47 ,  A61K31/505 ,  A61K31/165 ,  C07D215/52 ,  C07D239/72 ,  C07D217/26 ,  C07D401/04 ,  C07D417/04 ,  C07D401/06 ,  C07D401/12 ,  C07C103/76

CPC分类号： C07D401/04 ,  C07D211/26 ,  C07D215/52 ,  C07D217/26 ,  C07D239/72 ,  C07D401/06 ,  C07D401/12 ,  C07D417/04