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公开(公告)号：EP2637670B2
公开(公告)日：2024-03-13
申请号：EP11788077.3
申请日：2011-10-27
IPC分类号： A61K31/573 , A61K39/395
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公开(公告)号：EP3328893B1
公开(公告)日：2023-09-27
申请号：EP16757163.7
申请日：2016-08-01
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103.发明授权
公开(公告)号：EP2352763B2
公开(公告)日：2022-09-21
申请号：EP09736398.0
申请日：2009-10-01
发明人： KUFER, Peter , BLÜMEL, Claudia , KISCHEL, Roman
IPC分类号： C07K16/08
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公开(公告)号：EP3411402B1
公开(公告)日：2021-12-22
申请号：EP17703376.8
申请日：2017-02-02
发明人： RAUM, Tobias , MUENZ, Markus , BROZY, Johannes , KUFER, Peter , HOFFMANN, Patrick , FRIEDRICH, Matthias , RATTEL, Benno , BOGNER, Pamela , WOLF, Andreas , POMPE, Cornelius
IPC分类号： C07K16/28
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公开(公告)号：EP3043794B1
公开(公告)日：2021-09-01
申请号：EP14783554.0
申请日：2014-09-15
IPC分类号： A61K31/4045 , A61K39/395 , A61P35/02
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公开(公告)号：EP3328890B1
公开(公告)日：2020-10-07
申请号：EP16756951.6
申请日：2016-08-01
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公开(公告)号：EP3623385A8
公开(公告)日：2020-05-06
申请号：EP19192268.1
申请日：2012-11-15
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , A61P37/00
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：EP3623385A1
公开(公告)日：2020-03-18
申请号：EP19192268.1
申请日：2012-11-15
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , A61P37/00
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：EP3531133A1
公开(公告)日：2019-08-28
申请号：EP18213926.1
申请日：2015-05-20
发明人： Zugmaier, Gerhard , Kufer, Peter , Alekar, Shilpa
IPC分类号： G01N33/574
摘要： The present invention relates to a method for risk-stratifying subjects suffering from B-precursor acute lymphoblastic leukemia (ALL), wherein said subjects are intended for a therapy comprising administration of a CD3 binding domain. Risk-stratification is based on the determination of the amount blast cells in a bone marrow sample from said subject, and/or on the determination of the number of blast cells per 1 µl in a CSF sample from said subject. According to the category into which subjects are risk-stratified, said subjects can be appropriately treated, while their risk of a potential adverse neurological reaction can be reduced or even excluded.
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公开(公告)号：EP2982696B1
公开(公告)日：2019-03-27
申请号：EP15185767.9
申请日：2009-11-06
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