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公开(公告)号：EP2780375B1
公开(公告)日：2019-09-11
申请号：EP12805432.7
申请日：2012-11-15
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , A61P37/00
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公开(公告)号：EP2948477A1
公开(公告)日：2015-12-02
申请号：EP14705293.0
申请日：2014-01-27
发明人： XIAO, Shouhua , PAN, Zheng , WICKRAMASINGHE, Dineli , JEFFRIES, M., Shawn , KING, Chadwick Terence , CHAN, Brian Mingtung , KUFER, Peter , LUTTERBUESE, Ralf , RAUM, Tobias , HOFFMANN, Patrick , RAU, Doris , KISCHEL, Roman , LEMON, Bryan , WESCHE, Holger
CPC分类号： C07K16/2809 , A61K47/60 , A61K2039/505 , C07K16/28 , C07K16/2896 , C07K16/3053 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： The present invention provides to a antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
摘要翻译： 本发明提供一种抗体构建物，其包含能够结合靶细胞表面上的人CDH19的第一人结合结构域和能够结合T细胞表面上的人CD3的第二结构域。 此外，本发明涉及编码抗体构建体的核酸序列，包含所述核酸序列的载体和用所述载体转化或转染的宿主细胞。 此外，本发明涉及制备本发明的抗体构建体的方法，所述抗体构建体的医学用途和包含所述抗体构建体的试剂盒。
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公开(公告)号：EP3611193A1
公开(公告)日：2020-02-19
申请号：EP19196304.0
申请日：2012-11-15
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , A61P37/00
摘要： The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：EP2780374B1
公开(公告)日：2019-08-21
申请号：EP12803509.4
申请日：2012-11-15
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02 , A61P37/00
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公开(公告)号：EP3328890A1
公开(公告)日：2018-06-06
申请号：EP16756951.6
申请日：2016-08-01
发明人： RAUM, Tobias , DEISTING, Wibke , BLUEMEL, Claudia , PANZER, Marc , HOFFMANN, Patrick , NAHRWOLD, Elisabeth , NOLAN-STEVAUX, Olivier , LUTTERBUESE, Ralf
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human CD70 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：EP3912997A3
公开(公告)日：2021-12-15
申请号：EP21158075.8
申请日：2014-03-14
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：EP3699194A1
公开(公告)日：2020-08-26
申请号：EP19202926.2
申请日：2014-01-27
发明人： XIAO, Shouhua , PAN, Zheng , WICKRAMASINGHE, Dineli , JEFFRIES, M., Shawn , KING, Chadwick Terence , CHAN, Brian Mingtung , KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , RAU, Doris , KISCHEL, Roman , LEMON, Bryan , WESCHE, Holger , LUTTERBUESE, Ralf
摘要： The present invention provides to an antibody construct comprising a first human binding domain capable of binding to human CDH19 on the surface of a target cell and a second domain capable of binding to human CD3 on the surface of a T cell. Moreover, the invention relates to a nucleic acid sequence encoding the antibody construct, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：EP3186279A1
公开(公告)日：2017-07-05
申请号：EP15753906.5
申请日：2015-07-31
发明人： KUFER, Peter , HOFFMANN, Patrick , RAUM, Tobias , LUTTERBUESE, Ralf , NAHRWOLD, Elisabeth , BLUMEL, Claudia , XIAO, Shouhua , PAN, Zheng , WICKRAMASINGHE, Dineli
CPC分类号： C07K16/468 , A61K47/60 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K2317/21 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The present invention provides a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds a human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising the polynucleotide and a host cell transformed or transfected with the polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of the antibody construct in the treatment of melanoma, and a kit comprising the antibody construct.
摘要翻译： 本发明提供了双特异性抗体构建体，其包含与靶细胞表面上的人CDH19结合的第一人结合结构域和结合T细胞表面上的人CD3的第二结合结构域。 此外，本发明提供编码抗体构建体的多核苷酸，包含所述多核苷酸的载体以及用所述多核苷酸或载体转化或转染的宿主细胞。 此外，本发明提供了用于产生本发明的抗体构建体的方法，所述抗体构建体的医学用途以及包含所述抗体构建体的试剂盒。
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公开(公告)号：EP3912997A2
公开(公告)日：2021-11-24
申请号：EP21158075.8
申请日：2014-03-14
发明人： KUFER, Peter , RAUM, Tobias , HOFFMANN, Patrick , KISCHEL, Roman , LUTTERBUESE, Ralf , RAU, Doris , ADAM, Paul , BORGES, Eric , HEBEIS, Barbara , HIPP, Susanne
IPC分类号： C07K16/28 , A61K39/395 , A61K39/00 , A61P35/00
摘要： The present invention relates to a binding molecule comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope clusters of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.
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公开(公告)号：EP3328890B1
公开(公告)日：2020-10-07
申请号：EP16756951.6
申请日：2016-08-01
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