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    METHOD AND DEVICE FOR CAVITY-ENHANCED BROADBAND INTRAPULSE DIFFERENCE FREQUENCY GENERATION
    101.
    发明公开
    METHOD AND DEVICE FOR CAVITY-ENHANCED BROADBAND INTRAPULSE DIFFERENCE FREQUENCY GENERATION 审中-公开
    用于增强频带宽带突波差频率的方法和装置

    公开(公告)号：EP3186679A1

    公开(公告)日：2017-07-05

    申请号：EP15739515.3

    申请日：2015-07-13

    申请人： Ludwig-Maximilians-Universität München ,  Max-Planck-Gesellschaft zur Förderung der Wissenschaften

    发明人： APOLONSKIY, Alexander ,  FILL, Ernst ,  PUPEZA, Ioachim ,  KRAUSZ, Ferenc

    IPC分类号： G02F1/35

    CPC分类号： G02F1/3534 ,  G02F1/3501 ,  G02F2001/3503 ,  G02F2001/3507 ,  G02F2001/3542 ,  G02F2203/15

    摘要： A method of creating difference frequency (DF) laser pulses (1) by difference frequency generation (DFG) comprises the steps of providing ultrashort laser pulses (2) containing first spectral components and second spectral components having larger frequencies than the first spectral components, and driving a DFG process by the ultrashort laser pulses (2) in an optically non-linear crystal (10), wherein the DF laser pulses (1) are generated in the crystal (10) by difference frequencies between the first and second spectral components, resp., said difference frequencies comprising third spectral components being lower in frequency than the first and second spectral components, wherein at least one enhancement cavity (20) with resonator mirrors (M11 to M14) spanning a beam path (22) is provided and the crystal (10) is placed in the beam path (22) of the enhancement cavity (20), the ultrashort laser pulses (2) are input coupled and coherently added in the at least one enhancement cavity (20), at least one circulating ultrashort laser pulse (3) is created in the at least one enhancement cavity (20), which drives the DFG process in the crystal (10) for generating the DF laser pulses (1), and the at least one enhancement cavity (20) is adapted for recycling the at least one ultrashort laser pulse (3) passing through the crystal (10). Furthermore, a photonic source (100) for creating DF laser pulses (1) is described, including one or more enhancement cavities.

    摘要翻译： 通过差频产生（DFG）产生差频（DF）激光脉冲（1）的方法包括以下步骤：提供包含第一频谱分量和频率大于第一频谱分量的第二频谱分量的超短激光脉冲（2）;以及 在光学非线性晶体（10）中通过超短激光脉冲（2）驱动DFG过程，其中通过第一和第二光谱分量之间的差频在晶体（10）中产生DF激光脉冲（1） 所述差频包括频率低于所述第一和第二频谱分量的第三频谱分量，其中提供了具有跨越光路（22）的谐振器反射镜（M11至M14）的至少一个增强腔（20），并且所述 晶体10被放置在增强腔20的光束路径22中，超短激光脉冲2被输入耦合并且相干地添加在至少一个增强腔2中， 0），在至少一个增强腔（20）中产生至少一个循环超短激光脉冲（3），其驱动晶体（10）中的DFG过程以产生DF激光脉冲（1），并且at 至少一个增强腔（20）适于再循环穿过晶体（10）的至少一个超短激光脉冲（3）。 此外，描述了用于创建DF激光脉冲（1）的光子源（100），其包括一个或多个增强腔。

    EINBRINGPFOSTEN, SYSTEM UND VERFAHREN ZUM ERFASSE DER LAGE EINES EINGEBRACHTEN IMPLANTATS
    102.
    发明公开
    EINBRINGPFOSTEN, SYSTEM UND VERFAHREN ZUM ERFASSE DER LAGE EINES EINGEBRACHTEN IMPLANTATS 有权
    插入后，系统和方法检测到植入体的位置已经提升

    公开(公告)号：EP3113715A1

    公开(公告)日：2017-01-11

    申请号：EP15703911.6

    申请日：2015-01-29

    申请人： Ludwig-Maximilians-Universität München

    发明人： SCHWEIGER, Josef ,  BEUER, Florian

    IPC分类号： A61C8/00 ,  A61C9/00

    CPC分类号： A61C8/0001 ,  A61C8/0071 ,  A61C8/0089 ,  A61C9/0053

    摘要： The present invention relates to an insertion post (12) for inserting an implant (10) into a jaw bone. The insertion post (12) comprises a first drive portion (16) for transferring a torque to the insertion post (12), and a second drive portion for transferring a torque from the insertion post (12) to the implant (10). The insertion post (12) can be connected releasably to the implant (10) in such a way that in the connection there is a clear relationship between the position of the implant (10) and the position of the insertion post (12), and it comprises a scan body portion (14) which permits a determination of the position of the insertion post (12) by means of an intraoral scanner.

    摘要翻译： 本发明涉及在插入后（12），用于在植入物（10）插入到颚骨。 插入柱（12）包括用于传递环的第一驱动部（16）的扭矩到插入柱（12），以及用于传递环的第二驱动部分从插入柱（12）的转矩，以将植入物（10）。 插入柱（12）可释放地连接到所述植入物（10）后在寻求一种方式“那个”在连接有所述植入物（10）的位置之间的明确的关系和插入（12）的位置，和 它包括扫描主体部分（14），其通过口腔内扫描器的装置允许插入柱（12）的位置的确定。

    METHOD AND LASER PULSE SOURCE APPARATUS FOR GENERATING FS LASER PULSES
    104.
    发明公开
    METHOD AND LASER PULSE SOURCE APPARATUS FOR GENERATING FS LASER PULSES 审中-公开
    VERFAHREN UND LASERIMPULSQUELLENVORRICHTUNG ZUR ERZEUGUNG VON FS-LASERIMPULSEN

    公开(公告)号：EP3091620A1

    公开(公告)日：2016-11-09

    申请号：EP15001331.6

    申请日：2015-05-05

    申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. ,  Ludwig-Maximilians-Universität München

    发明人： Zhang, Jinwei ,  Brons, Jonathan ,  Pronin, Oleg

    IPC分类号： H01S3/081 ,  H01S3/098 ,  H01S3/06 ,  H01S3/08 ,  H01S3/16

    CPC分类号： H01S3/1095 ,  H01S3/0604 ,  H01S3/0805 ,  H01S3/081 ,  H01S3/0811 ,  H01S3/0813 ,  H01S3/1068 ,  H01S3/1112 ,  H01S3/1618 ,  H01S3/1643

    摘要： A method of generating fs laser pulses (1), comprises the steps of creating a circulating light field in a resonator cavity (10) with multiple resonator mirrors (11 - 18) by pumping at least one gain medium (21, 22) included in the resonator cavity (10), and passing the circulating light field through a first Kerr medium (31) included in the resonator cavity (10), so that the fs laser pulses (1) are formed by self-amplitude modulation of the circulating light field, wherein the resonator cavity (10) includes at least one supplementary Kerr medium (32 - 36) enhancing the self-amplitude modulation of the circulating light field, and each of the first Kerr medium (31) and the at least one supplementary Kerr medium (32 - 36) provide different non-linear Kerr lens contributions to the self-amplitude modulation of the circulating light field. Furthermore, a laser pulse source apparatus (100) for generating fs laser pulses (1) is described.

    摘要翻译： 一种产生fs激光脉冲（1）的方法，包括以下步骤：通过泵送至少一个增益介质（21,22）来产生具有多个谐振器反射镜（11-18）的谐振腔（10）中的循环光场， 谐振器腔（10），并使循环光场通过包含在谐振器腔（10）中的第一克尔介质（31），使得fs激光脉冲（1）通过循环光的自调幅形成 场，其中所述谐振器腔（10）包括增强所述循环光场的自振幅调制的至少一个补充克尔介质（32-36），并且所述第一克尔介质（31）和所述至少一个补充克尔 介质（32-36）为循环光场的自调幅提供不同的非线性克尔透镜。 此外，描述了用于产生fs激光脉冲（1）的激光脉冲源设备（100）。

    Photo-switchable sulfonylureas and their uses
    107.
    发明公开
    Photo-switchable sulfonylureas and their uses 审中-公开
    Photoschaltbare Sulfonylharnstoffe und deren Verwendungen

    公开(公告)号：EP3009422A1

    公开(公告)日：2016-04-20

    申请号：EP14188799.2

    申请日：2014-10-14

    申请人： Ludwig-Maximilians-Universität München

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： C07C311/58 ,  C07C311/59 ,  C07D285/135 ,  A61K31/64 ,  A61P3/10

    CPC分类号： C07C311/58 ,  A61K31/64 ,  A61K45/06 ,  C07C311/59 ,  C07C2601/14 ,  C07D285/135 ,  A61K2300/00

    摘要： The present invention relates to sulfonylurea analogous compounds comprising a sulfonylurea moiety and a photoresponsive moiety. The present invention further relates to methods for generating the sulfonylurea analogous compounds of the invention and to pharmaceutical compositions comprising at least one sulfonylurea analogous compound of the invention. The present invention relates to the sulfonylurea analogous compounds or the pharmaceutical composition of the invention for use in medicine, in particular for use as anti-diabetic agent and/or in the prevention and/or treatment of diabetes conditions or a disease state requiring modulation of ATP-sensitive potassium (K + ) (K ATP ) channels. The present invention also relates to the use of the sulfonylurea analogous compounds for regulating ATP-sensitive potassium (K + ) (K ATP ) channels and/or for assessing the functional role and/or activation of K ATP channels.

    摘要翻译： 本发明涉及包含磺酰脲部分和光响应部分的磺酰脲类似物。 本发明还涉及产生本发明的磺酰脲类似物的方法和包含本发明的至少一种磺酰脲类似化合物的药物组合物。 本发明涉及用于医药，特别是用作抗糖尿病剂和/或用于预防和/或治疗糖尿病状况或需要调节的疾病状态的本发明的磺酰脲类似物或药物组合物 ATP敏感钾（K +）（K ATP）通道。 本发明还涉及磺酰脲类似物质用于调节ATP敏感钾（K +）（K ATP）通道和/或用于评估K ATP通道的功能作用和/或活化的用途。

    A system and method for inducing and detecting multi-photon processes in a sample
    109.
    发明公开
    A system and method for inducing and detecting multi-photon processes in a sample 审中-公开
    系统和Verfahren zum Induzieren和Nachweisen von Multiphotonprozessen在einer Probe

    公开(公告)号：EP2953215A1

    公开(公告)日：2015-12-09

    申请号：EP14192304.5

    申请日：2014-11-07

    申请人： Ludwig-Maximilians-Universität München

    发明人： Huber, Robert Alexander ,  Karpf, Sebastian ,  Eibl, Matthias

    IPC分类号： H01S3/10 ,  H01S3/30 ,  H01S3/094

    CPC分类号： G01N21/6456 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/65 ,  G01N2021/6484 ,  G01N2201/06146 ,  G01N2201/0635 ,  G01N2201/105 ,  G01N2201/11 ,  G01N2201/12 ,  H01S3/06712 ,  H01S3/06754 ,  H01S3/094007 ,  H01S3/10015 ,  H01S3/1618 ,  H01S3/2316 ,  H01S3/302 ,  H01S2301/02

    摘要： Described is a system for inducing and detecting multi-photon processes, in particular multi-photon fluorescence or higher harmonic generation in a sample. The system comprises a dynamically-controllable light source, said dynamically-controllable light source comprising a first sub-light source, said first sub-light source being electrically controllable such as to generate controllable time-dependent intensity patterns of light having a first wavelength, and at least one optical amplifier, thereby allowing for active time-control of creation of multi-photon-excitation. The system further comprises a beam delivery unit for delivering light generated by said dynamically-controllable light source to a sample site, and a detector unit or detector assembly for detecting signals indicative of said multi-photon process, in particular multi-photon fluorescence signals or higher harmonics signals.

    摘要翻译： 描述了用于诱导和检测多光子过程，特别是样品中的多光子荧光或更高次谐波产生的系统。 该系统包括动态可控光源，所述动态可控光源包括第一子光源，所述第一子光源是电可控制的，以便产生具有第一波长的光的可控时间依赖强度图案， 和至少一个光放大器，从而允许对多光子激发的产生的主动时间控制。 该系统还包括用于将由所述动态可控光源产生的光传送到采样点的光束传送单元，以及用于检测指示所述多光子过程，特别是多光子荧光信号的信号的检测器单元或检测器组件， 高次谐波信号。