公开(公告)号：EP3678780A1

公开(公告)日：2020-07-15

申请号：EP18779131.4

申请日：2018-09-06

申请人： The Charles Stark Draper Laboratory, Inc.

发明人： BORENSTEIN, Jeffrey, T. ,  BALESTRINI, Jenna, L. ,  TANDON, Vishal ,  KRATCHMAN, Louis, B.

IPC分类号： B01L3/00 ,  C12M3/06 ,  C12M1/12 ,  C12M1/42

公开(公告)号：EP3411115B1

公开(公告)日：2020-03-04

申请号：EP17704625.7

申请日：2017-01-30

申请人： The Charles Stark Draper Laboratory, Inc.

发明人： BERNSTEIN, Jonathan ,  FREEMAN, Daniel ,  IRION, Reed ,  INGERSOLL, Brett ,  DUWEL, Amy ,  CZARNECKI, Andrew ,  DANIELS, Brian ,  ACHYUTA, Anilkumar Harapanahalli ,  MCLAUGHLIN, Bryan

IPC分类号： A61N1/378 ,  A61N1/372 ,  H01L41/00 ,  A61N1/375 ,  A61N1/36 ,  H02N2/18

公开(公告)号：EP3599475A1

公开(公告)日：2020-01-29

申请号：EP19185356.3

申请日：2019-07-09

申请人： The Charles Stark Draper Laboratory, Inc.

发明人： MARIANO, Laura J. ,  IRVINE, John M.

IPC分类号： G01R33/46

摘要： A 2-D MRS (magnetic resonance spectroscopy), or equivalently, NMR (nuclear magnetic resonance), pre-processing method produces clean MRS signals from raw data for possible use, among other applications, for diagnoses of neurological disorders such as PTSD and mTBI of the brain. The specific 2-D MRS data referred to in this invention are the 2-D MRS Correlation Spectroscopy or 2-D COSY data.

公开(公告)号：EP3598940A1

公开(公告)日：2020-01-29

申请号：EP19187144.1

申请日：2019-07-18

申请人： The Charles Stark Draper Laboratory, Inc.

发明人： MARIANO, Laura J. ,  IRVINE, John M. ,  KESHAVA, Nirmal

IPC分类号： A61B5/055 ,  A61B5/00 ,  G01R33/465 ,  G01R33/485

摘要： A MRS (magnetic resonance spectroscopy or nuclear magnetic resonance NMR)-based PTSD (post-traumatic stress disorder) and mTBI (mild traumatic brain injury) diagnostic system and method uses MRS signals, already pre-processed by the MRS scanner software. The signals are collected in vivo from specific regions of the brain. A wavelet decomposition is applied to the MRS signals, and the amplitude of the wavelet coefficients and their location in the MRS signals are used as features for training diagnostic classifiers of disease states. These classifiers are identified through analysis of features of individuals whose health status is known. Once the classifiers are trained, patients can be diagnosed by using the same wavelet features extracted from in vivo MRS scans of their brain regions.

公开(公告)号：EP3562546A1

公开(公告)日：2019-11-06

申请号：EP18707586.6

申请日：2018-02-14

申请人： The Charles Stark Draper Laboratory Inc.

发明人： WHEELER, Jesse ,  LACHAPELLE, John ,  BJUNE, Caroline, K. ,  PARKS, Philip, D., II ,  SEGURA, Carlos

IPC分类号： A61N1/372 ,  A61N1/05 ,  A61N1/36 ,  A61B5/01 ,  A61B5/021 ,  A61B5/024 ,  A61B5/03 ,  A61B5/04

公开(公告)号：EP3548891A1

公开(公告)日：2019-10-09

申请号：EP17817973.5

申请日：2017-11-29

申请人： The Charles Stark Draper Laboratory, Inc.

发明人： ANGIONE, Stephanie ,  COOPER, Madeline ,  COPPETA, Jonathan ,  MULHERN, Thomas ,  AZIZGOLSHANI, Hesham

IPC分类号： G01N33/543 ,  C12Q1/6834

公开(公告)号：EP3522981A1

公开(公告)日：2019-08-14

申请号：EP17859066.7

申请日：2017-10-04

申请人： The Charles Stark Draper Laboratory, Inc. ,  Board of Regents, The University of Texas System

发明人： COGAN, Stuart ,  FREEMAN, Daniel Kenneth ,  O'BRIEN, Jonathan Michael ,  ROMERO-ORTEGA, Mario

IPC分类号： A61N1/372 ,  A61N1/378

公开(公告)号：EP3516422A1

公开(公告)日：2019-07-31

申请号：EP16781618.0

申请日：2016-09-29

申请人： The Charles Stark Draper Laboratory, Inc. ,  VEONEER US INC.

发明人： DEBITETTO, Paul ,  GRAHAM, Matthew ,  JONES, Troy ,  LOMMEL, Peter ,  DEMERLY, Jon, D.

IPC分类号： G01S19/45 ,  G01S19/46 ,  G01S19/48 ,  G01S19/49 ,  G01C21/28 ,  G01S13/06

公开(公告)号：EP3509837A2

公开(公告)日：2019-07-17

申请号：EP17849562.8

申请日：2017-09-07

申请人： The Government Of The United States Of America As The Secretary of The Navy ,  The Charles Stark Draper Laboratory, Inc.

发明人： KUB, Francis, J. ,  HOBART, Karl, D. ,  IMHOFF, Eugene, A. ,  MYERS-WARD, Rachael, L. ,  COOK, Eugene ,  BERNSTEIN, Jonathan ,  WEINBERG, Marc

IPC分类号： B32B9/00 ,  B81B7/02

公开(公告)号：EP3500179A1

公开(公告)日：2019-06-26

申请号：EP17762276.8

申请日：2017-08-22

申请人： The Charles Stark Draper Laboratory, Inc. ,  The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： BERLIN, Andrew, A. ,  DESAI, Salil ,  RIED, Thomas ,  SALTHOUSE, Chris

IPC分类号： A61B10/02 ,  A61B5/00