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公开(公告)号：EP3548891A1
公开(公告)日：2019-10-09
申请号：EP17817973.5
申请日：2017-11-29
发明人： ANGIONE, Stephanie , COOPER, Madeline , COPPETA, Jonathan , MULHERN, Thomas , AZIZGOLSHANI, Hesham
IPC分类号： G01N33/543 , C12Q1/6834
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公开(公告)号：EP4388071A1
公开(公告)日：2024-06-26
申请号：EP22772660.1
申请日：2022-08-19
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公开(公告)号：EP4025684A1
公开(公告)日：2022-07-13
申请号：EP20790088.7
申请日：2020-09-04
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公开(公告)号：EP4025683A1
公开(公告)日：2022-07-13
申请号：EP20780816.3
申请日：2020-09-04
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公开(公告)号：EP3831923A1
公开(公告)日：2021-06-09
申请号：EP20211221.5
申请日：2020-12-02
发明人： BORENSTEIN, Jeffrey , MOORE, Nathan , DOTY, Daniel , HAGGERTY, Timothy , CHAREST, Joseph , GIMBEL, Alla , MOTT, Vienna , ISENBERG, Brett , AZIZGOLSHANI, Hesham , CAIN, Brian , MESCHER, Mark
摘要： A microfluidic device for modeling a tumor-immune microenvironment can include a multiwell plate defining a plurality of microenvironment units fluidically coupled with a plurality of wells. Each microenvironment unit of the plurality of microenvironment units can include one or more compartments. Each microenvironment unit can include a trapping feature positioned within the one or more compartments. The trapping feature can be defined by a portion of at least one of a sidewall or a floor of the one or more compartments. The trapping feature can restrict movement of a tissue sample introduced into the one or more compartments and to allow fluid to flow past the tissue sample. The microfluidic device can include a plurality of micropumps each coupled with a respective well and configured to control movement of a respective fluid sample through each respective well.
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