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公开(公告)号：EP2898100A4
公开(公告)日：2016-05-11
申请号：EP13838770
申请日：2013-09-20
发明人： CHIU ROSSA WAI KWUN , CHAN KWAN CHEE , LO YUK-MING DENNIS , LUN MIU FAN , JIANG PEIYONG , CHAN WAI MAN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6886 , C12Q2600/154
摘要： Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal/tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother/patient. A methylation profile can be determined for fetal/tumor tissue using tissue-specific alleles to identify DNA from the fetus/tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus/tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer.
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公开(公告)号：EP2883466A4
公开(公告)日：2016-03-16
申请号：EP13827494
申请日：2013-07-29
发明人： CHAN CHEEKOOI , PENG SIXIANG , LUXIMON AMEERSING
IPC分类号： A41H5/01
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113.发明公开NONINVASIVE PRENATAL DIAGNOSIS OF FETAL TRISOMY BY ALLELIC RATIO ANALYSIS USING TARGETED MASSIVELY PARALLEL SEQUENCING 有权利用靶向大规模并行测序法进行同种异体分析的无创性初步诊断
公开(公告)号：EP2834376A4
公开(公告)日：2015-11-18
申请号：EP13773129
申请日：2013-04-08
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/156 , C12Q2600/158 , G06F19/20 , G06F19/22 , C12Q2537/16
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公开(公告)号：EP2670435A4
公开(公告)日：2015-03-11
申请号：EP12741908
申请日：2012-01-18
申请人： UNIV HONG KONG
发明人： NG LUI OILIN IRENE , TUNG KWOKKWAN
IPC分类号： A61K39/395 , A61P35/00 , C07K16/18 , C07K16/30 , G01N33/574
CPC分类号： C07K16/303 , C07K16/18 , C07K2317/76 , G01N33/57438
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公开(公告)号：EP2720722A4
公开(公告)日：2014-12-03
申请号：EP12800682
申请日：2012-06-15
CPC分类号： A61K31/795 , A61K31/10 , A61K31/573 , A61K31/721 , A61K31/728 , A61K31/734 , C07K16/22
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116.发明公开PHARMACEUTICAL COMPOSITION CONTAINING CYCLOMETALATED N-HETEROCYCLIC CARBENE COMPLEXES FOR CANCER TREATMENT 有权与ZYKLOMETALLIERTEN N-杂环卡宾用于癌症治疗的药物组合物
公开(公告)号：EP2493896A4
公开(公告)日：2014-09-10
申请号：EP10825938
申请日：2010-10-27
申请人： UNIV HONG KONG
发明人： CHE CHIMING , SUN WAIYIN RAYMOND , CHOW LOKFUNG , YAN JING
IPC分类号： C07F1/12 , A61K31/787 , A61K35/00 , A61P35/02 , A61P35/04 , C07F17/00 , C07F17/02 , C08F132/00 , C08F134/00
CPC分类号： C07F15/0086 , A61K31/555 , C07F1/00
摘要： The present disclosure is related to a pharmaceutical composition for treatment of cancer comprising a cyclometalated N-heterocyclic carbene complex. The cyclometalated N-heterocyclic carbene complex contains a gold(III) or a platinum(II) atom. The pharmaceutical composition possesses anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of topoisomerase and/or poisoning of topoisomerase.
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公开(公告)号：EP2638061A4
公开(公告)日：2014-02-19
申请号：EP11839154
申请日：2011-11-11
申请人： UNIV HONG KONG
发明人： CHEN ZHIWEI , ZHOU JINGYING
IPC分类号： C07K14/705 , A61K38/17 , A61P31/18 , A61P35/00 , C07K19/00 , C12N1/21 , C12N15/11 , C12N15/62
CPC分类号： C07K14/70521 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/57 , C07K14/005 , C07K2319/00 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C12N2740/16034 , C12N2740/16222
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公开(公告)号：EP2229189A4
公开(公告)日：2013-05-15
申请号：EP09703458
申请日：2009-01-16
申请人： UNIV HONG KONG , YUEN CHI KEUNG
发明人： YUEN CHI KEUNG , IP WING YUK
CPC分类号： A61L27/58 , A61L27/04 , A61L27/38 , A61L27/427 , A61L31/005 , A61L31/022 , A61L31/124 , A61L31/148 , B33Y80/00
摘要： The present invention relates to uses of resorbable medical implants that are metallic or semi-metallic, to produce soft tissues, membranous tissues, organs or organ parts within the body by fibrosis. The present invention further relates to such uses when the implants are made of specified alloys or metals, e.g. magnesium and its alloys. The present invention further relates to such uses when the implant is surface modified. The present invention further relates to such uses when the implant is pre-implanted at another part of the body before implantation into the target site.
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公开(公告)号：EP2459584A4
公开(公告)日：2013-02-13
申请号：EP10803809
申请日：2010-07-29
发明人： CHO CHI HIN , LI ZHIJIE
IPC分类号： C07K7/06 , A61K49/00 , C07K14/47 , C07K14/705
CPC分类号： C07K14/47 , A61K38/00 , A61K49/0002 , A61K49/0043 , A61K49/0056 , C07K7/06 , C07K14/705
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120.发明公开METHOD OF INDUSTRIALLY PRODUCING A YARN AND THE TEXTILE PRODUCT THEREOF, AND A RING SPINNING MACHINE THAT CARRIES THE METHOD 审中-公开用于纱线的工业生产和纺织产品以及一种环锭纺纱机方法用于执行该方法
公开(公告)号：EP2176453A4
公开(公告)日：2011-07-20
申请号：EP08750969
申请日：2008-05-13
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