公开(公告)号：EP1407006B9

公开(公告)日：2006-10-18

申请号：EP02787945.1

申请日：2002-12-13

申请人： Bavarian Nordic A/S

发明人： HELLER, Karl ,  KRAMER, Jutta

IPC分类号： C12N7/02 ,  C12N15/86 ,  A61K39/275

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/275 ,  C12N15/86 ,  C12N2710/24143 ,  C12N2710/24151

摘要： The present invention relates to a method for the recovery of poxviruses, in particular modified Vaccinia virus Ankara (MVA), from infected cells. According to the present invention the virus-infected cells are subjected to a high-pressure homogenization to obtain a virus containing homogenate. The virus containing homogenate can be subjected to at least one purification step to obtain apoxvirus-enriched fraction. The invention further relates to the virus containing fraction and the virus containing homogenate obtained by the method according to the present invention.

公开(公告)号：EP1689872A1

公开(公告)日：2006-08-16

申请号：EP04790902.3

申请日：2004-10-27

申请人： Bavarian Nordic A/S

发明人： LEYRER, Sonja

IPC分类号： C12N15/86 ,  A61K39/275

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/285 ,  A61K48/00 ,  A61K2039/5256 ,  C12N15/86 ,  C12N2710/24143

摘要： The invention concerns promoters, in particular for the expression of genes and/or coding sequences in vaccinia viruses such as Modified vaccinia virus Ankara (MVA). The invention further concerns expression cassettes comprising said promoter, vectors comprising said expression cassettes as well as pharmaceutical compositions and vaccines.

公开(公告)号：EP1506223B1

公开(公告)日：2005-11-16

申请号：EP03730029.0

申请日：2003-05-14

申请人： Bavarian Nordic A/S

发明人： HOWLEY, Paul ,  LEYRER, Sonja ,  FELDER, Eva

IPC分类号： C07K14/16 ,  C12N15/62

CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/40 ,  C12N2710/24143 ,  C12N2740/16322 ,  C12N2740/16334

摘要： The invention relates to fusion proteins comprising the amino acid sequence of at least four HIV proteins selected from Vif, Vpr, Vpu, Rev, Tat and Nef or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins having the natural N and C termini. The invention further concerns nucleic acids encoding said proteins, vectors comprising said nucleic acids, and methods for producing said proteins. The fusion protein, nucleic acids and vectors are usable as vaccines for the at least partial prophylaxis against HIV infections.

公开(公告)号：EP1536015A1

公开(公告)日：2005-06-01

申请号：EP04000943.3

申请日：2004-01-17

申请人： Bavarian Nordic A/S

发明人： Leyrer, Sonja, Dr.

IPC分类号： C12N15/86 ,  A61K39/275

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/285 ,  A61K48/00 ,  A61K2039/5256 ,  C12N15/86 ,  C12N2710/24143

摘要： The invention concerns promoters, in particular for the expression of genes and/or coding sequences in vaccinia viruses such as Modified vaccinia virus Ankara (MVA). The invention further concerns expression cassettes comprising said promoter, vectors comprising said expression cassettes as well as pharmaceutical compositions and vaccines.

公开(公告)号：EP1420822A2

公开(公告)日：2004-05-26

申请号：EP03732280.7

申请日：2003-04-16

申请人： Bavarian Nordic A/S

发明人： CHAPLIN, Paul ,  SUTER, Mark ,  ACKERMANN, Mathias ,  FRANCHINI, Marco ,  VOLLSTEDT, Sabine ,  HEFTI, Hans, Peter

IPC分类号： A61K39/285 ,  A61K39/245

CPC分类号： A61K39/285 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/5254 ,  A61K2039/55 ,  A61K2039/58 ,  C12N7/00 ,  C12N2710/16634 ,  C12N2710/24134 ,  C12N2710/24143 ,  C12N2710/24151 ,  C12N2710/24161 ,  Y02A50/386 ,  Y02A50/39 ,  Y02A50/394

摘要： The invention concern the use of a virus for the preparation of a medicament for the vaccination or treatment of a neonatal or prenatal animal, including a human, wherein the virus is capable of infecting the cells of the neonatal or prenatal animal, including a human, but not capable of being replicated to infectious progeny virus in the neonatal or prenatal animal, including a human. The virus is preferably a Modified Vaccinia Virus Ankara. In particular, the invention concerns the vaccination of neonates against infections with viruses belonging the same virus group than the virus used for vaccination. Moreover, the invention concerns the vaccination of neonates against antigens selected from foreign antigens and tumour antigens, wherein the tumour antigen and/or the foreign antigen are different from the antigens associated with the virus. The invention further concerns the use of viruses as defined above to increase the level of factors which activate dendritic cells or their precursor cells and/or to increase the number of dendritic cells or their precursor cells and/or to increase the production and/or cellular content of an interferon (IFN) or IL-12.

公开(公告)号：EP0948319B1

公开(公告)日：2003-10-22

申请号：EP97954822.9

申请日：1997-12-18

申请人： Bavarian Nordic A/S ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： PIECHACZYK, Marc ,  PELEGRIN, Mireia, Les Jardins du Château ,  MARIN, Mariana, Résidence La Charmeraie ,  SALLER, Robert ,  SALMONS, Brian

IPC分类号： A61K9/16 ,  A61K9/50

CPC分类号： A61K9/1635 ,  A61K9/1652 ,  A61K9/5026 ,  A61K9/5042

摘要： The present invention relates to capsules encapsulating antibody-producing cells, and to the use of such capsules and encapsulated cells, respectively, for implantation in vivo for long term delivery or sustained delivery of antibodies of therapeutic interest.

公开(公告)号：EP4164682A1

公开(公告)日：2023-04-19

申请号：EP21731178.6

申请日：2021-06-10

申请人： Bavarian Nordic A/S

发明人： HAUSMANN, Jürgen ,  STEIGERWALD, Robin ,  HABJAN, Matthias ,  MEDINA ECHEVERZ, Jose ,  RAMBICHLER, Stephan

IPC分类号： A61K39/12 ,  A61P31/14

公开(公告)号：EP3988651A1

公开(公告)日：2022-04-27

申请号：EP21204501.7

申请日：2008-05-07

申请人： Bavarian Nordic A/S

发明人： POST HANSEN, Sara ,  DJURUP, René

IPC分类号： C12N7/02

摘要： The present invention relates to methods for purification of Vaccinia viruses (VV) and/ or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production.

公开(公告)号：EP3971298A2

公开(公告)日：2022-03-23

申请号：EP21190638.3

申请日：2014-11-25

申请人： Bavarian Nordic A/S

发明人： Hausmann, Jürgen ,  Wolferstätter, Michael

IPC分类号： C12N15/86

摘要： Provided herein are recombinant poxviruses comprising heterologous or native nucleic acids specifying excess double-stranded RNA (dsRNA) early in infection, which may further comprise heterologous nucleic acids encoding one or more costimulatory molecules, and/or heterologous nucleic acids encoding one or more infectious disease-associated antigens or tumor-associated antigens, as well as pharmaceutical compositions comprising such recombinant poxviruses and methods and uses thereof. The recombinant poxviruses provided herein enhance innate and adaptive immune activation in subjects compared to identical recombinant poxviruses lacking heterologous or native transcription units specifying excess early dsRNA.

公开(公告)号：EP3142689B1

公开(公告)日：2020-11-11

申请号：EP15724454.2

申请日：2015-05-08

申请人： Bavarian Nordic A/S

发明人： FOY, Susan ,  MANDL, Stefanie ,  ROUNTREE, Ryan

IPC分类号： A61K39/00 ,  A61K39/395