公开(公告)号：EP1123000B1

公开(公告)日：2004-12-29

申请号：EP99960142.0

申请日：1999-10-22

申请人： Medtronic, Inc. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： LASKE, Timothy, Gerald ,  IAIZZO, Paul, A. ,  HJELLE, Mark, A. ,  MORISSETTE, Josee ,  WAHLSTROM, Dale, A.

IPC分类号： A01N1/02

CPC分类号： A01N1/02 ,  A01N1/0247

公开(公告)号：EP0956355B1

公开(公告)日：2004-10-20

申请号：EP97937274.5

申请日：1997-08-13

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： FOSTER, Douglas, N. ,  FARRIS, James, A. ,  FOSTER, Linda, K.

IPC分类号： C12N15/79 ,  C12N5/10 ,  C07K14/47 ,  C12N7/00

CPC分类号： C07K14/4746 ,  C12N7/00 ,  C12N2710/16351 ,  C12N2720/12051

摘要： This invention relates to the introduction of p53 under the control of the metallothionein promoter into primary cells to produce immortalized cell lines. The cells are useful as substrates for viral propagation, as contaminant-free sources for recombinant protein production, for recombinant virus production and as cell substrates to support primary cells and improve virus yield during virus propagation.

公开(公告)号：EP1458228A2

公开(公告)日：2004-09-22

申请号：EP02734541.2

申请日：2002-05-23

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： BLANCHETTE, Robert, A. ,  VAN BEEK, Henry, Heuveling

IPC分类号： A01B79/00

CPC分类号： A01G23/10 ,  A61K36/83 ,  A61K36/835

摘要： The present invention provides agarwood and/or agarwood resin from cultivated trees, and methods of generating agarwood and/or agarwood resin in cultivated trees.

公开(公告)号：EP1386180A1

公开(公告)日：2004-02-04

申请号：EP02719421.6

申请日：2002-04-01

申请人： Regents of the University of Minnesota

发明人： LIU, Haiying ,  CHEN, Wei ,  UGURBIL, Kamil

IPC分类号： G01V3/00

CPC分类号： G01R33/4625

摘要： NMR spectroscopy data recovery methods and apparatus for improving the quality of an NMR spectrum are disclosed. The NMR spectrum is improved by acquiring more than the half spin-echo data signal(301) and using an iterative numerical method to reconstruct the missing data points of the corresponding full symmetrical spin-echo data signal. The method includes filtering the initial data signal to extract a low-resolution phase term (302). The low-resolution phase term is used to form a phase-constrained initial data signal, which is Fourier-transformed to obtain a reconstructed data signal (303). The reconstructed data signal is modified to include the original spin-echo signal data (304). The formation of the reconstructed spin-echo data signal and subsequent modification is iterated until convergence is obtained. The reconstructed data signal is then Fourier-transformed to form a reconstructed NMR spectrum (305).

公开(公告)号：EP1304383A3

公开(公告)日：2003-12-17

申请号：EP02076967.5

申请日：1997-08-13

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Olszewski, Neil ,  Lockhart, Benham ,  Tzafrir, Iris ,  Somers, David A. ,  Torbert, Kimberly A.

IPC分类号： C12N15/82 ,  A01H5/00

CPC分类号： C07K14/005 ,  C12N15/8216 ,  C12N15/8222 ,  C12N2730/00022

摘要： An isolated and purified DNA molecule comprising a sugarcane bacilliform virus promoter and expression cassettes comprising said promoter are provided. Also provided is a method of using a sugarcane bacilliform virus promoter to express proteins, RNA transcripts, or mixtures thereof, in transgenic plants.

摘要翻译： 提供了包含甘蔗杆状病毒启动子的分离和纯化的DNA分子和包含所述启动子的表达盒。 还提供了使用甘蔗杆状病毒启动子在转基因植物中表达蛋白质，RNA转录物或其混合物的方法。

公开(公告)号：EP0801082B1

公开(公告)日：2003-04-09

申请号：EP97111264.4

申请日：1991-08-27

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Barany, George ,  Chang, Jane ,  Sole, Nuria A. ,  Albericio, Fernando ,  Zalipski, Samuel

IPC分类号： C08F8/00 ,  C07K1/04

CPC分类号： C07K1/042 ,  C08F8/00 ,  C08G65/329 ,  Y02P20/55 ,  C08F12/08

公开(公告)号：EP1289554A1

公开(公告)日：2003-03-12

申请号：EP01941869.8

申请日：2001-06-01

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Wijkstrom, Martin ,  Kirchhof, Nicole

发明人： HERING, Bernhard, J. ,  WIJKSTROM, Martin ,  KIRCHHOF, Nicole

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2812 ,  A61K2039/505 ,  C07K16/2875

摘要： A method for the prevention or reversal of islet cell transplant rejection, or for therapy for autoimmune diseases, is provided comprising administering compounds such as monoclonal antibodies, that bind specifically to CD40L and the CD4 receptor.

公开(公告)号：EP1145731A3

公开(公告)日：2002-10-23

申请号：EP01303108.3

申请日：2001-04-02

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  University of Virginia Patent Foundation

发明人： Kucharczyk, John ,  Gillies, George T.

IPC分类号： A61M25/00

CPC分类号： A61B5/14503 ,  A61B5/14539 ,  A61B5/411 ,  A61B5/416 ,  A61B2562/17 ,  A61M2025/0036 ,  A61M2025/004

摘要： A multi-lumen, multi-functional catheter (2) system comprising a plurality of axial lumens (6,8,10,12,14,16), at least one lumen supporting a functionality other than material delivery and material removal.

公开(公告)号：EP0682526B1

公开(公告)日：2002-09-04

申请号：EP94909571.5

申请日：1994-02-08

申请人： Avant Immunotherapeutics, Inc. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： LEVIN, James L. ,  REGAL, Jean F. ,  TOTH, Carol A.

IPC分类号： A61K38/55 ,  A61K9/72 ,  A61K38/17 ,  A61K9/00 ,  A61P11/00

CPC分类号： A61K9/0078 ,  A61K38/00 ,  C07K14/705

摘要： The present invention relates to formulations for pulmonary administration by inhalation that comprise a complement inhibitory protein, and uses thereof in the prophylactic or therapeutic treatment of diseases or disorders involving complement, especially diseases or disorders of the lung. In particular, the proteins are complement receptors of fragments thereof or soluble members of the complement receptor family that contain the conserved SCR motif and that are able to inhibit complement activity. More particularly the present invention relates to the direct treatment of certain complement related lung disorders by administering complement receptor proteins via the pulmonary route, in particular, direct delivery to the lungs of a complement receptor protein by aerosolization and subsequent inhalation. The invention also relates to use of a complement inhibitory protein to treat bronchoconstriction or anaphylaxis, or both.

公开(公告)号：EP1231942A1

公开(公告)日：2002-08-21

申请号：EP00922210.0

申请日：2000-04-15

申请人： MAYO FOUNDATION FOR MEDICALEDUCATION AND RESEARCH ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： HOGENKAMP, Henricus, P., C. ,  COLLINS, Douglas, A.

IPC分类号： A61K47/48 ,  A61K51/04

CPC分类号： A61K51/041 ,  A61K47/551 ,  A61K51/04 ,  A61K51/0485

摘要： The invention provides cobalamin derivatives which are useful for medical treatment and diagnosis.