公开(公告)号：EP1140080A1

公开(公告)日：2001-10-10

申请号：EP99958307.3

申请日：1999-12-13

申请人： Aventis Pharma S.A.

发明人： STUTZMANN, Jean-Marie ,  RANDLE, John

IPC分类号： A61K31/425

CPC分类号： A61K31/00 ,  Y10S514/878 ,  Y10S514/879

摘要： The invention concerns the use of riluzole or one of its pharmaceutically acceptable salts for preventing and/or treating acoustic traumas and, in particular, different types of deafness and tinnitus.

公开(公告)号：EP1133295A1

公开(公告)日：2001-09-19

申请号：EP99956108.7

申请日：1999-11-22

申请人： Aventis Pharma S.A.

发明人： DIB, Michel ,  MEININGER, Vincent

IPC分类号： A61K31/48 ,  A61P21/00 ,  A61P25/00

CPC分类号： A61K31/435 ,  Y02A50/465

摘要： The invention concerns the use of nicergoline for treating pyramidal spasmodism of neurological diseases involving a pathology of the cerebrospinal tract.

公开(公告)号：EP1128829A1

公开(公告)日：2001-09-05

申请号：EP99972101.2

申请日：1999-11-09

申请人： Aventis Pharma S.A.

发明人： DIB, Michel

IPC分类号： A61K31/425

CPC分类号： A61K31/425 ,  A61K31/355 ,  A61K2300/00

摘要： The invention concerns a combination of alpha-tocopherol and riluzole or a pharmaceutically acceptable salt thereof and the use of said combination for treating amyotrophic lateral sclerosis.

公开(公告)号：EP2381922B1

公开(公告)日：2012-10-24

申请号：EP09805745.8

申请日：2009-12-18

申请人： Pierre Fabre Dermo-Cosmétique

发明人： FIORINI-PUYBARET, Christel

IPC分类号： A61K8/97 ,  A61Q5/02 ,  A61Q5/00

CPC分类号： A61K8/97 ,  A61Q5/00 ,  A61Q5/02

公开(公告)号：EP2478085A2

公开(公告)日：2012-07-25

申请号：EP10762719.2

申请日：2010-09-10

申请人： Pierre Fabre Medicament

发明人： SAMSON, Arnaud

IPC分类号： C12M1/18 ,  B01L3/00

CPC分类号： C12M23/12 ,  B01L3/5085 ,  B01L2300/0829 ,  Y10T29/49

摘要： The subject of the present invention is a microplate, or microtitration plate, having an invagination consisting of a continuous peripheral channel making it possible to add thereto, in a single delivery step, a liquid acting as "evaporation curtain". The invention also relates to a device comprising such a microplate, to a manufacturing process and to the use of such a microplate.

公开(公告)号：EP2445480A2

公开(公告)日：2012-05-02

申请号：EP10734255.2

申请日：2010-06-17

申请人： Pierre Fabre Dermo-Cosmétique

发明人： MANDEAU, Anne ,  DUPLAN, Hélène

IPC分类号： A61K8/97 ,  A61Q19/08 ,  A61K8/92

CPC分类号： A61Q19/08 ,  A61K8/922 ,  A61K8/97

摘要： The present invention relates to an extract of whole seeds of
Moringa sp. , containing oil (having triglycerides, fatty acids, and polar lipids) and polyphenols, and to the use thereof in cosmetic and/or dermatological compositions.

公开(公告)号：EP2079482B1

公开(公告)日：2011-02-23

申请号：EP07858450.5

申请日：2007-10-15

申请人： Pierre Fabre Medicament

发明人： HAEUW, Jean-François ,  GOETSCH, Liliane

IPC分类号： C07K16/28

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/34

摘要： The present invention relates to the use of at least one antibody, or a functional fragment thereof, capable of binding to the CD151 protein and thus of inhibiting tumour growth, for the preparation of a medicament for use in the treatment of cancer. The invention also relates to a composition for the treatment of cancer, comprising, as active ingredient, at least one anti-CD151 antibody, or a functional fragment thereof, capable of binding to the CD151 protein and/or of inhibiting the development of primary tumours and/or of inhibiting its metastasis-promoting activity, wherein said antibodies may consist of the TS151 and/or TS151r antibodies.

公开(公告)号：EP2089374B1

公开(公告)日：2010-08-04

申请号：EP07870250.3

申请日：2007-11-06

申请人： Pierre Fabre Medicament

发明人： VACHER, Bernard ,  BRUNEL, Yves ,  MAUREL, Jean-Louis

IPC分类号： C07D327/02 ,  C07C323/20

CPC分类号： C07D327/02 ,  C07B2200/07 ,  C07C319/20 ,  C07C323/20

摘要： The invention relates to a new method for preparing N- [3- [ (2-methoxyphényl) sulfanyl] -2-methylpropyl] -3,4- dihydro-2H-1, 5-benzoxathiepin-3-amine.

公开(公告)号：EP1450750B1

公开(公告)日：2009-10-21

申请号：EP02793210.2

申请日：2002-11-07

申请人： Aventis Pharma S.A.

发明人： BACQUE, Eric ,  BIGOT, Antony ,  CARRY, Jean-Christophe ,  MIGNANI, Serge ,  RONAN, Baptiste ,  TABART, Michel

IPC分类号： C07D417/06 ,  A61K31/4178

CPC分类号： C07D213/40 ,  C07D213/55 ,  C07D213/64 ,  C07D213/89 ,  C07D417/06 ,  C07F7/1856

摘要： The invention concerns the use of 2-amino-4-pyridylmethyl-thiazoline derivatives of formula (I), wherein: either R1 = R2 = Cl, or C1-C4 alkyl, or hydroxy; or C1-C4 alkoxy or at least one of the two R1 and R2 is hydrogen and the other a C1-C4 alkyl radical, a hydroxy, a C1-C4 alkoxy or a chlorine or their pharmaceutically acceptable salts as inhibitors of inducible NO-synthase.

公开(公告)号：EP2079482A2

公开(公告)日：2009-07-22

申请号：EP07858450.5

申请日：2007-10-15

申请人： Pierre Fabre Medicament

发明人： HAEUW, Jean-François ,  GOETSCH, Liliane

IPC分类号： A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/34

摘要： The present invention relates to the use of at least one antibody, or a functional fragment thereof, capable of binding to the CD151 protein and thus of inhibiting tumour growth, for the preparation of a medicament for use in the treatment of cancer. The invention also relates to a composition for the treatment of cancer, comprising, as active ingredient, at least one anti-CD151 antibody, or a functional fragment thereof, capable of binding to the CD151 protein and/or of inhibiting the development of primary tumours and/or of inhibiting its metastasis-promoting activity, wherein said antibodies may consist of the TS151 and/or TS151r antibodies.