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    Processes using a phosphorus complex
    122.
    发明公开
    Processes using a phosphorus complex 失效
    使用磷复合物的方法

    公开(公告)号：EP0283270A3

    公开(公告)日：1989-12-20

    申请号：EP88302305.3

    申请日：1988-03-16

    申请人： ICI AMERICAS INC.

    发明人： Timony, Peter Edward ,  Bay, Elliott ,  Leone-Bay, Andrea

    IPC分类号： C07F9/54 ,  C07B39/00

    CPC分类号： C07C17/093 ,  C07B39/00 ,  C07C17/16 ,  C07C22/06 ,  C07C19/01 ,  C07C25/06

    摘要： A process for the preparation of a phosphorus complex corresponding to the following general formula:
    wherein R represents optionally substituted aryl, wherein the substitution may comprise at least one selected from nitro, chloro, fluoro, alkyl, fluoro-alkyl and alkoxy, or optionally substituted alkyl; characterised in that it comprises reacting phosphorus pentachloride and a phosphonic dichloride corresponding to the following general formula:
        RPOCl₂
    wherein R is as defined above; in the presence of an inert solvent boiling at a temperature of from 120 to 150°C, which is capable of co-distilling a phosphorus oxychloride reaction product, and co-distilling a phosphorus oxychloride reaction product, the molar ratio of phosphorus pentachloride:phosphonic dichloride being from 0.1:1 to 10:1 is disclosed. There is further disclosed a process for chlorinating compounds containing a carbon atom bonded to a hetero-atom selected from oxygen, nitrogen and sulfur which comprises contacting the carbon hetero-atom containing compound with a chloro phosphorus complex corresponding to the following general formula:
    wherein R represents optionally substituted aryl or optionally substituted alkyl, so that the hetero-atom is replaced by at least one chlorine atom; the reaction may be extended to compounds containing the carbon to chlorine bond alpha to a carbon atom having at least one hydrogen atom, it may be further dehydrochlorinated by either heating to a temperature of from 50 to 300°C or by reaction with a selected base.

    摘要翻译： 一种制备对应于下列通式的磷络合物的方法：其中R代表任意取代的芳基，其中取代基可以包括选自硝基，氯，氟，烷基，氟 - 烷基和烷氧基中的至少一种， 或任选取代的烷基; 其特征在于它包括使五氯化磷与对应于以下通式的膦酰氯反应：RPOCl 2，其中R如上定义; 在沸点为120〜150℃的惰性溶剂的存在下，其能够共同蒸馏三氯氧化磷反应产物，并共同蒸馏出三氯氧化磷反应产物，五氯化磷：膦酸的摩尔比 公开了二氯化物为0.1:1至10:1。 还公开了一种氯化含有与选自氧，氮和硫的杂原子键合的碳原子的化合物的方法，该方法包括使含碳杂杂原子的化合物与对应于以下通式的氯磷络合物接触：其中R表示任选取代的芳基或任选取代的烷基，使得杂原子被至少一个氯原子代替; 该反应可以延伸至含有至少一个氢原子的碳原子的碳与氯键的化合物，也可以通过加热至50至300℃的温度或通过与选定的碱反应而进一步脱氯化氢 。

    Aminophenol derivatives
    123.
    发明公开
    Aminophenol derivatives 失效
    氨基酚衍。

    公开(公告)号：EP0343866A1

    公开(公告)日：1989-11-29

    申请号：EP89305073.2

    申请日：1989-05-19

    申请人： ICI AMERICAS INC.

    发明人： Schwartz, John Anthony

    IPC分类号： C07D241/28 ,  A61K31/495

    CPC分类号： C07D241/26 ,  Y10S514/869

    摘要： Certain amine containing phenolic pyrazines of formula III possess eukalemic diuretic properties and are of value in treating diseases and conditions in which a eukalemic diuretic effect is required, for example in treating edema, hypertension and/or related conditions.

    摘要翻译： 某些含有式III的胺类吡嗪类化合物具有有益的利尿利尿性质，并且在治疗需要用于患有白血病利尿作用的疾病和病症方面是有价值的，例如在治疗水肿，高血压和/或相关病症中。

    Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists
    125.
    发明公开
    Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists 失效
    酰基磺酰胺 - 衍生物vonα-Carbocyclyltoluylsäurenund ihre Verwendung als Leukotrienantagonisten。

    公开(公告)号：EP0337765A2

    公开(公告)日：1989-10-18

    申请号：EP89303621.0

    申请日：1989-04-12

    申请人： ICI AMERICAS INC.

    发明人： Brown, Frederick Jeffrey ,  Maduskuie, Thomas Peter, Jr. ,  Matassa, Victor Giulio ,  Yee, Ying Kwong

    IPC分类号： C07C311/51 ,  A61K31/18 ,  C07D295/18 ,  C07C233/65 ,  C07C233/63 ,  A61K31/535

    CPC分类号： C07C311/51

    摘要： This invention comprises novel carbocyclic compounds of formula I (wherein A, Z, R¹¹ and R¹² are defined in the specification) derived from acylsulfon­amide derivatives of α-carbocyclyltoluic acids wherein said compounds of formula I antagonize the actions of one or more of the arachidonic acid metabolites known as leukotrienes. The invention also provides pharma­ceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.

    摘要翻译： 本发明包括衍生自α-碳环丙酰甲酰基酸的酰基磺酰胺衍生物的式I（其中A，Z，R 1和R 1）的新型碳环化合物，其中所述式 我对抗一种或多种称为白三烯的花生四烯酸代谢物的作用。 本发明还提供式I化合物的药学上可接受的盐; 含有式I化合物或其盐的药物组合物，用于治疗例如过敏性或炎症性疾病或内毒素性或创伤性休克病症; 以及用于制造式I化合物的方法以及用于此类制备的中间体。

    Non-crystalline tris(2-methyl-4-hydroxy-5-tert.butylphenyl)butane
    126.
    发明公开
    Non-crystalline tris(2-methyl-4-hydroxy-5-tert.butylphenyl)butane 失效
    Nichtkristallines三（2-甲基-4-羟基-5-叔丁基苯基）丁烷。

    公开(公告)号：EP0318319A1

    公开(公告)日：1989-05-31

    申请号：EP88311211.2

    申请日：1988-11-25

    申请人： ICI AMERICAS INC.

    发明人： Smith, Jerry Howard ,  Stephen, John Fergus

    IPC分类号： C07C39/15

    CPC分类号： C07C39/15

    摘要： A non-crystalline 1,1,3-tris(2-methyl-4-hydroxy-5-tert-­butylphenyl)butane having an amorphous X-ray diffraction pattern and a melt transition temperature of 113-119°C is made by an improved process and offers improvements over crystalline materials as a stabiliser of polymeric materials such as polypropylene.

    摘要翻译： 具有无定形X射线衍射图和113-119℃熔融转变温度的非结晶1,1,3-三（2-甲基-4-羟基-5-叔丁基苯基）丁烷由 改进的方法，并提供作为聚合物材料如聚丙烯的稳定剂的结晶材料的改进。

    Fungicidal pyridyl cyclopropane carboxamidines
    127.
    发明公开
    Fungicidal pyridyl cyclopropane carboxamidines 失效
    Fungizide吡啶基环丙烷甲脒。

    公开(公告)号：EP0314429A2

    公开(公告)日：1989-05-03

    申请号：EP88310013.3

    申请日：1988-10-25

    申请人： ICI AMERICAS INC.

    发明人： Baker, Don Robert ,  Brownell, Keith Harvey

    IPC分类号： C07D213/75 ,  A01N53/00

    CPC分类号： C07D213/75 ,  A01N53/00

    摘要： Novel fungicidal pyridyl cyclopropane carboxamidines having the general structural formula
    and tautomers thereof wherein
    R is selected from the group consisting of hydrogen, pyridyl, substituted pyridyl, C₁-C₃ alkoxy, C₁-C₆ alkyl, acyl, carbamoyl, sulfonyl and cyano;
    R₁ is selected from the group consisting of halogen, C₁-C₃ alkoxy and C₁-C₃ alkenyloxy;
    R₂ is selected from the group consisting of hydrogen and C₁-C₃ alkyl;
    R₃ is selected from the group consisting of hydrogen, alkyl, aryl or arylalkyl;
    and fungicidally acceptable organic and inorganic salts thereof.

    摘要翻译： 具有一般结构式的新型杀真菌吡啶环丙烷甲酰胺及其互变异构体，其中R选自氢，吡啶基，取代的吡啶基，C 1 -C 3烷氧基，C 1 -C 6烷基，酰基，氨基甲酰基，磺酰基和氰基; R 1选自卤素，C 1 -C 3烷氧基和C 1 -C 3烯氧基; R 2选自氢和C 1 -C 3烷基; R3选自氢，烷基，芳基或芳基烷基; 和杀真菌可接受的有机和无机盐。

    Composition for external use containing an ethoxylated compound
    129.
    发明公开
    Composition for external use containing an ethoxylated compound 失效
    Zusammensetzung zuräusserlichenVerabreichung，die eine Ethoxylat-Verbindungenthält。

    公开(公告)号：EP0307083A2

    公开(公告)日：1989-03-15

    申请号：EP88306949.4

    申请日：1988-07-28

    申请人： ICI AMERICAS INC.

    发明人： Greenshields, James Nairn ,  Walters, Peter Paul

    IPC分类号： A61K7/48 ,  A61K7/06 ,  A61K7/15

    CPC分类号： A61K8/39 ,  A61K8/86 ,  A61Q11/00 ,  A61Q15/00 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/002 ,  A61Q19/10 ,  Y10S424/10 ,  Y10S514/83 ,  Y10S514/919

    摘要： A composition for external use contains at least one active ingredient and a capped ethoxylated alcohol of the formula RO(EO) x R¹ where R and R¹ are both hydrocarbon or substituted hydrocarbon and x is at least two. R is preferably a higher alkyl group and R¹ is a lower alkyl group. x is preferably at least 4. The ethoxylated alcohol is typically used in an amount to provide a soothing effect. The ethoxylated alcohol may be incorporated into cosmetic or pharmaceutical compositions such as shaving cream, pre-­and after-shave lotions, sunburn lotions, lotions and creams for chapped lips etc., insect bite lotions etc., mouth wash, and anti-perspirant.

    摘要翻译： 外用组合物含有至少一种式RO（EO）xR 1的活性成分和封端的乙氧基化醇，其中R和R 1都是烃或取代的烃，x是至少两个。 R优选为高级烷基，R 1为低级烷基。 x优选为至少4.乙氧基化醇通常以提供舒缓作用的量使用。 乙氧基化醇可以掺入到化妆品或药物组合物中，例如剃须膏，剃须前和剃须后的乳液，晒伤乳液，用于劈裂的嘴唇的洗剂和乳霜等，昆虫咬乳液等，漱口水和防汗剂。