IMPROVED DUAL SPECIFICITY POLYPEPTIDE MOLECULE
    124.
    发明公开

    公开(公告)号:EP3428194A1

    公开(公告)日:2019-01-16

    申请号:EP18183508.3

    申请日:2018-07-13

    IPC分类号: C07K16/46

    摘要: The present invention relates to a bispecific polypeptide molecule comprising a first polypeptide chain and a second polypeptide chain providing a binding region derived from a T cell receptor (TCR) being specific for a major histocompatibility complex (MHC)-associated peptide epitope, and a binding region derived from an antibody capable of recruiting human immune effector cells by specifically binding to a surface antigen of said cells, as well as methods of making the bispecific polypeptide molecule, and uses thereof.