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公开(公告)号：EP4450087A2
公开(公告)日：2024-10-23
申请号：EP24194122.8
申请日：2018-03-23
IPC分类号： A61K39/395
摘要： The present invention pertains to antigen recognizing constructs against tumor associated antigens (TAA), in particular against Preferentially Expressed Antigen of Melanoma (PRAME). The invention in particular provides novel T cell receptor (TCR) based molecules which are selective and specific for the tumor expressed antigen of the invention. The TCR of the invention, and TAA binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of TAA expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.
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2.发明公开
公开(公告)号：EP4321529A3
公开(公告)日：2024-07-17
申请号：EP23216383.2
申请日：2019-02-08
发明人： Schuster, Heiko , Hoffgaard, Franziska , Fritsche, Jens , Schoor, Oliver , Weinschenk, Toni , Kowalewski, Daniel , Tsou, Chih-Chiang
CPC分类号： A61K38/08 , C07K7/06 , C07K14/4748 , A61P37/00 , A61P35/00 , C12N5/0636 , A61K39/001102 , A61K39/4644 , A61K39/001114 , A61K39/001118 , A61K39/4611 , A61K35/17
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：EP4377330A1
公开(公告)日：2024-06-05
申请号：EP22755209.8
申请日：2022-07-27
发明人： YOUSEF, Sara , BRUNK, Fabian , MORITZ, Andreas , BUNK, Sebastian , WAGNER, Claudia , MAURER, Dominik , UNVERDORBEN, Felix
IPC分类号： C07K14/47 , A61P35/00 , C07K16/30 , A61K39/00 , C07K14/725
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公开(公告)号：EP4277649A1
公开(公告)日：2023-11-22
申请号：EP22702170.6
申请日：2022-01-14
发明人： HANNEN, Ricarda , HUKELMANN, Jens , KÖHLER, Florian , KOWALEWSKI, Daniel , SCHUSTER, Heiko , SCHOOR, Oliver , RÖMER, Michael , TSOU, Chih-Chiang , FRITSCHE, Jens
IPC分类号： A61K39/00
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5.发明公开
公开(公告)号：EP4219524A3
公开(公告)日：2023-10-18
申请号：EP22211062.9
申请日：2017-04-05
发明人： Mahr, Andrea , Weinschenk, Toni , WIEBE, Anita , Schoor, Oliver , Fritsche, Jens , Singh, Harpreet
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：EP4219543A1
公开(公告)日：2023-08-02
申请号：EP23150210.5
申请日：2018-11-05
发明人： MAURER, Dominik , HOFMANN, Martin , HUTT, Meike , BUNK, Sebastian , UNVERDORBEN, Felix , ALTEN, Leonie , WAGNER, Claudia
IPC分类号： C07K14/725 , C07K14/78 , A61P35/00 , A61K39/00 , C07K16/28 , C07K16/18 , C07K16/30 , C12N5/0783 , C12N15/62
摘要： The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.
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公开(公告)号：EP4032544A3
公开(公告)日：2022-12-21
申请号：EP21207265.6
申请日：2017-12-07
IPC分类号： A61K39/00 , C07K14/725 , C07K14/47
摘要： The present invention pertains to antigen recognizing constructs against tumor associated antigens (MAGEA1). The invention in particular provides novel T cell receptor (TCR) based molecules which are selective and specific for the tumor expressed antigen of the invention. The TCR of the invention, and TAA binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of TAA expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.
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公开(公告)号：EP4007778A1
公开(公告)日：2022-06-08
申请号：EP20754675.5
申请日：2020-07-31
发明人： PSZOLLA, Gabriele , HOFMANN, Martin , UNVERDORBEN, Felix , HUTT, Meike , MAURER, Dominik , BUNK, Sebastian
IPC分类号： C07K16/46
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公开(公告)号：EP3985029A1
公开(公告)日：2022-04-20
申请号：EP21191794.3
申请日：2018-07-13
IPC分类号： C07K16/46
摘要： The present invention relates to a bispecific polypeptide molecule comprising a first polypeptide chain and a second polypeptide chain providing a binding region derived from a T cell receptor (TCR) being specific for a major histocompatibility complex (MHC)-associated peptide epitope, and a binding region derived from an antibody capable of recruiting human immune effector cells by specifically binding to a surface antigen of said cells, as well as methods of making the bispecific polypeptide molecule, and uses thereof.
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10.发明公开
公开(公告)号：EP3897698A2
公开(公告)日：2021-10-27
申请号：EP19831680.4
申请日：2019-12-18
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