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公开(公告)号：EP4361139A1
公开(公告)日：2024-05-01
申请号：EP22864455.5
申请日：2022-08-29
发明人： NAGAI, Mitsuo , FUKUYAMA, Takashi , KAMADA, Yasuaki , NIIJIMA, Jun , KURODA, Hirofumi , KAROJI, Yuki , MURAKAMI, Keiichi , OMORI, Masayuki , MIYASHITA, Yusuke , KAMADA, Atsushi , MATSUDA, Masaaki
IPC分类号： C07D401/12 , C07D209/32
CPC分类号： Y02P20/55 , C07D401/12 , C07D209/32
摘要： The invention provides a production process allowing more high-yield and efficient synthesis of key intermediates (compound (2i) or a salt thereof, and compound (1g)) for production of E7090, which is useful as an FGFR inhibitor.
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公开(公告)号：EP4361138A1
公开(公告)日：2024-05-01
申请号：EP22827611.9
申请日：2022-06-22
发明人： QIAN, Wenyuan , YANG, Chundao
IPC分类号： C07D401/12 , C07D401/14 , C07D409/14 , C07D411/14 , C07D417/14 , A61K31/444 , A61K31/497 , A61P29/00 , A61P37/00
CPC分类号： A61K31/444 , A61K31/497 , A61P29/00 , A61P37/00 , C07D401/12 , C07D401/14 , C07D409/14 , C07D417/14 , C07D411/14
摘要： A sulfoximine compound and a use thereof. Specifically disclosed is a compound represented by the following formula or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP4361137A1
公开(公告)日：2024-05-01
申请号：EP22204452.1
申请日：2022-10-28
发明人： ZOLLO, Massimo , ASADZADEH, Fatemeh , FERRUCCI, Veronica , DE ANTONELLIS, Pasqualino , BIBBO', Francesca , SORICE, Carmen
IPC分类号： C07D401/04 , A61P35/00 , A61K31/53
CPC分类号： C07D401/04 , A61P35/00
摘要： There are disclosed compounds able to modulate and specifically inhibit the activity of Prune1 protein, pharmaceutical compositions containing them and the use thereof alone or in combination with chemotherapeutic agents in the prevention or treatment of Prune 1-overexpressing tumors and metastasis.
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公开(公告)号：EP4359400A1
公开(公告)日：2024-05-01
申请号：EP22744048.4
申请日：2022-06-22
CPC分类号： C07D401/14 , C07C55/10 , C07C55/12 , C07C57/15 , C07B2200/1320130101
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公开(公告)号：EP4175951B1
公开(公告)日：2024-05-01
申请号：EP21742686.5
申请日：2021-07-02
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： A61P35/00 , C07D401/14 , C07D413/14 , C07D471/04 , C07D498/04 , A61K45/06 , C07D519/00 , C07D491/107 , C07D487/04 , C07D473/32 , C07F9/65583 , C07F9/6561
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公开(公告)号：EP3724178B1
公开(公告)日：2024-05-01
申请号：EP18830663.3
申请日：2018-12-17
IPC分类号： C07D401/14 , C07D401/06 , C07D471/04 , C07D471/10 , C07D491/113 , C07D495/04 , C07D491/107 , C07D491/20 , C07D495/10 , C07D497/10 , A61K31/496 , A61P35/00 , A61P35/02
CPC分类号： C07D471/10 , C07D491/107 , C07D491/20 , C07D495/04 , C07D495/10 , C07D497/10 , A61P35/00 , A61P35/02 , C07D401/06 , C07D401/14 , C07D471/04 , C07D491/113
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127.发明公开
公开(公告)号：EP4355741A1
公开(公告)日：2024-04-24
申请号：EP22744559.0
申请日：2022-06-15
申请人： Biotheryx, Inc.
发明人： CHAN, Kyle W.H. , CHOURASIA, Aparajita Hoskote , ERDMAN, Paul E. , FUNG, Leah M. , HECHT, David Aaron , LAM, Imelda , PAPA, Patrick , SCHOOLMEESTERS, Angela , TORRES, Eduardo
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/517 , A61P35/00
CPC分类号： A61P35/00 , C07D401/12 , C07D401/14 , C07D403/14 , C07D403/12
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公开(公告)号：EP4353717A1
公开(公告)日：2024-04-17
申请号：EP22862531.5
申请日：2022-01-31
申请人： Mindrank AI Ltd.
发明人： ZHANG, Long , NIU, Zhangming , TANG, Bowen
IPC分类号： C07D401/14 , C07D405/14 , C07D405/06 , C07D409/14 , C07D471/04 , A61K31/506 , A61K31/496 , A61P3/00
CPC分类号： A61K31/496 , A61K31/506 , A61P3/00 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D471/04
摘要： The present invention relates to a novel aryl ether substituted heterocyclic compound having GLP1R agonist activity. Specifically, disclosed are a compound as a GLP1R agonist represented by formula (I), or a pharmaceutically acceptable salt, solvate, hydrate, isotope substituent or isomer thereof.
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公开(公告)号：EP4353712A1
公开(公告)日：2024-04-17
申请号：EP22306531.9
申请日：2022-10-11
申请人： Biodol Therapeutics , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique , UNIVERSITE DE MONTPELLIER , Université de Strasbourg
IPC分类号： C07D215/40 , C07D217/02 , C07D237/30 , C07D241/42 , C07D401/12 , A61P29/00 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/502
CPC分类号： C07D401/12 , C07D215/40 , C07D217/02 , C07D237/30 , C07D241/42 , A61P29/00
摘要： The present invention relates to a compound of formula (I) or any of its acceptable salts (I)
wherein W, X, Y and Z each independently represents =CH- or -N-, provided that at most two of W, X, Y and Z both represent a -N- group, R1 represents a linear or cyclic nitrogen containing (C4-C8)alkyl group, said group being a non aromatic (C4-C8)alkyl group that can be linear or cyclic comprising 4 to 8 carbon atoms that contains at least one nitrogen atom, that interrupts said alkyl chain, said group being optionally interrupted by one or two oxygen atoms and optionally substituted by a (C1-C4)alkyl group or by a (C3-C6)cycloalkyl group, R2 represents a hydrogen atom, a halogen atom, a (C1-C4)alkyl group, a (C1-C4)alkoxy group, a (C1-C4)fluoroalkyl group, a -CO-(C1-C4)alkyl group, a -CONH2 group, a SO2-NH2 group or a cyano group, R3 represents a hydrogen atom, a halogen atom, a (C1-C4)alkyl group, a (C1-C4)alkoxy group, a (C1-C4)fluoroalkyl group, a cyano group, a (C1-C4)alkylsulfonyl group or a SO2-NH2 group, and R4, R5 and R6 independently represent a hydrogen atom, a halogen atom, a -COOH group, a (C1-C4)fluoroalkyl group, a (C1-C4)alkylsulfonyl group or a (C1-C4)alkoxy group.
The present invention further related to a pharmaceutical composition comprising it and to its use in the prevention and/or the treatment of pain.-
公开(公告)号：EP4351653A1
公开(公告)日：2024-04-17
申请号：EP22820971.4
申请日：2022-06-08
发明人： STRUTHERS, R. Scott , ZHAO, Jian , ZHU, Yunfei
IPC分类号： A61K47/54 , A61K51/04 , A61P35/00 , C07D401/14
CPC分类号： A61P35/00 , C07D405/14 , A61K47/545 , C07D417/14 , C07D491/22 , C07D475/00 , C07K5/06034
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