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公开(公告)号：EP4062942A1
公开(公告)日：2022-09-28
申请号：EP21163944.8
申请日：2021-03-22
IPC分类号： A61K47/54 , A61K47/55 , C07D275/04 , A61P35/00 , A61P37/00
摘要： The present application relates to a compound having the formula (I)
A-L-B (I)
wherein
A is represented by
L is a bond or a self-immolative spacer;
B is represented by
The compound is capable of releasing molecular cargo in the presence of a reductase and is thus suitable for treating, ameliorating, preventing or diagnosing a disorder selected from a neoplastic disorder; atherosclerosis; an autoimmune disorder; an inflammatory disease; a chronic inflammatory autoimmune disease; ischaemia; and reperfusion injury.-
12.发明公开
公开(公告)号：EP4061560A1
公开(公告)日：2022-09-28
申请号：EP20808418.6
申请日：2020-11-20
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公开(公告)号：EP3984527A1
公开(公告)日：2022-04-20
申请号：EP20201629.1
申请日：2020-10-13
摘要： Method for producing high yield nano-in-micro (NIM) encapsulated bioactive siRNA dry powder comprising the steps of:
- providing an aqueous suspension comprising polyplexes, in particular polyelectrolyte complexes, formed from at least a polyamine, and/or polyamide and/or polyester and siRNA, wherein the polyplexes are provided with and/or encapsulated into water soluble excipients, in particular highly purified water and/or sugar alcohol and/or sugar;
- spray drying the aqueous suspension using a spray drying apparatus, preferably a Büchi B-290, by feeding the aqueous suspension to a spray drying atomizing nozzle and subjecting the atomized droplets to a heated gas stream of a carrier gas, preferably dried and cleaned air, in particular through a multicomponent atomizing nozzle for the suspension and an atomizing gas;
- collecting a spray dried powder in an accumulation means of the spray drying apparatus
characterized in that
the temperature in the vicinity of an outlet opening of the spray drying apparatus, in particular an outlet opening connecting a spray drying chamber with the accumulation means, during feeding of the aqueous suspension to the nozzle is controlled by temperature controlling means to be limited to an upper threshold temperature which is equal to or below a melting temperature of the respective naked siRNA.-
公开(公告)号：EP3878924A1
公开(公告)日：2021-09-15
申请号：EP20162632.2
申请日：2020-03-12
摘要： A method of forming a nitridophosphate is disclosed, the method including forming a precursor mixture by combining a metal source material, a phosphorus source material, and a nitrogen source material, and heating the precursor mixture at a maximum temperature between 800 °C and 1300°C in an atmosphere including nitrogen gas at a pressure between 2 MPa and 500 MPa.
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公开(公告)号：EP3847188A1
公开(公告)日：2021-07-14
申请号：EP19762132.9
申请日：2019-08-30
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公开(公告)号：EP3699142A1
公开(公告)日：2020-08-26
申请号：EP19461514.2
申请日：2019-02-20
IPC分类号： C01B32/184 , B82Y15/00 , C12Q1/68 , G01N27/414 , C01B32/194
摘要： Method of immobilization of nucleic acid structures on graphene, said method comprising the steps of providing at least one type of nucleic acid structure having at least one type of molecule-modified oligonucleotide, wherein said molecule is able to attach to graphene via π-interactions, and contacting said nucleic acid structure having at least one type of molecule-modified oligonucleotide with graphene layer at temperature from the range of 0-100 °C, so that immobilization of nucleic acid structures on the graphene is achieved.
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17.发明公开
公开(公告)号：EP3689450A1
公开(公告)日：2020-08-05
申请号：EP19154191.1
申请日：2019-01-29
摘要： The invention relates to a method for producing a metal organic framework, MOF, film (12) on a substrate (14). The method comprises providing a precursor solution (22) on a main surface (14a) of the substrate (14), the precursor solution (22) comprising organic building blocks (30) and metallic precursors (32), wherein the organic building blocks (30) and the metallic precursors (32) are selected to form organometallic compounds (34) allowing a formation of an anisotropic MOF. The method further comprises forming a MOF film (12) on the main surface (14a) of the substrate (14) by forming organometallic compounds (34) from at least some of the organic building blocks (30) and at least some of the metallic precursors (32) of the precursor solution (22), wherein a modulator (28) is provided for mediating at least partly the morphology of the MOF film (12) during the formation of the MOF film (12) such as to increase a roughness of the MOF film (12). The invention further relates to a MOF and the use of a MOF.
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公开(公告)号：EP3475296A1
公开(公告)日：2019-05-01
申请号：EP17731842.5
申请日：2017-06-13
发明人： RÖMER, Lin , SLOTTA, Ute , ENGERT, Julia , WINTER, Gerhard , LUCKE, Matthias , SCHEIBEL, Thomas
IPC分类号： C07K14/435 , C12N15/62 , A61K38/00
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