公开(公告)号：EP4062942A1

公开(公告)日：2022-09-28

申请号：EP21163944.8

申请日：2021-03-22

申请人： Ludwig-Maximilians-Universität München

发明人： Thorn-Seshold, Oliver ,  Thorn-Seshold, Julia ,  Felber, Jan ,  Zeisel, Lukas

IPC分类号： A61K47/54 ,  A61K47/55 ,  C07D275/04 ,  A61P35/00 ,  A61P37/00

摘要： The present application relates to a compound having the formula (I)

         A-L-B     (I)

wherein
A is represented by

L is a bond or a self-immolative spacer;
B is represented by

The compound is capable of releasing molecular cargo in the presence of a reductase and is thus suitable for treating, ameliorating, preventing or diagnosing a disorder selected from a neoplastic disorder; atherosclerosis; an autoimmune disorder; an inflammatory disease; a chronic inflammatory autoimmune disease; ischaemia; and reperfusion injury.