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11.发明授权
公开(公告)号：EP3215509B1
公开(公告)日：2020-02-26
申请号：EP15856385.8
申请日：2015-11-06
发明人： SKERLJ, Renato, T. , LANSBURY, Peter, T. , GOOD, Andrew, C. , BOURQUE, Elyse Marie, Josée , SILVERMAN, Richard B. , KRAINC, Dimitri , ZHENG, Jianbin
IPC分类号： C07D487/04 , A61K31/519 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P43/00
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12.发明公开
公开(公告)号：EP3440083A1
公开(公告)日：2019-02-13
申请号：EP17779798.2
申请日：2017-04-06
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公开(公告)号：EP3313387A1
公开(公告)日：2018-05-02
申请号：EP16815292.4
申请日：2016-06-23
IPC分类号： A61K31/17 , A61K31/423 , A61K31/513 , A61P25/16 , A61P25/28
CPC分类号： A61K31/513 , A61K31/423
摘要： The invention relates to the treatment of neurodegenerative disorders with ceramidase inhibitor.
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公开(公告)号：EP3452481A1
公开(公告)日：2019-03-13
申请号：EP17793402.3
申请日：2017-05-05
IPC分类号： C07D487/14 , C07D513/04 , C07D495/04 , C07D491/048 , C07D498/04 , A61K31/519 , A61P25/16 , A61P27/06 , A61P3/10 , A61P13/12 , A61P25/24 , A61P25/28 , A61P25/08 , A61P25/18 , A61P25/22 , A61P43/00
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15.发明公开
公开(公告)号：EP3440081A1
公开(公告)日：2019-02-13
申请号：EP17779799.0
申请日：2017-04-06
发明人： SKERLJ, Renato, T. , BOURQUE, Elyse Marie Josee , LANSBURY,Peter, T. , GREENLEE, William, J. , GOOD, Andrew, C.
IPC分类号： C07D487/04 , A61K31/519 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P43/00
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16.发明公开
公开(公告)号：EP3429590A1
公开(公告)日：2019-01-23
申请号：EP17767536.0
申请日：2017-03-16
IPC分类号： A61K31/519 , A61P25/16 , A61P25/28
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17.发明公开
公开(公告)号：EP3344632A1
公开(公告)日：2018-07-11
申请号：EP16843038.7
申请日：2016-09-02
IPC分类号： C07D513/04 , C07D498/04 , C07D471/04 , A61K31/542 , A61K31/4985 , A61P25/16 , A61P3/10 , A61P13/12 , A61P25/08 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/06 , A61P43/00 , A61P35/00 , A61P25/00
CPC分类号： C07D513/04 , C07D487/04 , C07D498/04
摘要： The invention provides heterobicyclic pyrimidinone compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary heterobicyclic pyrimidinone compounds described herein include 6-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b)][1,3]thiazine-7-carboxamide compounds.
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18.发明公开
公开(公告)号：EP3344625A1
公开(公告)日：2018-07-11
申请号：EP16843039.5
申请日：2016-09-02
IPC分类号： C07D471/04 , C07D513/04 , A61K31/519 , A61P25/16 , A61P25/24 , A61P25/28 , A61P27/06 , A61P35/02 , A61P3/10 , A61P13/12
CPC分类号： C07D513/04 , C07D471/04
摘要： The invention provides heterobicyclic pyrimidinone compounds such as thiazolo[3,2-a]pyrimidinone compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary heterobicyclic pyrimidinone compounds described herein include 5-oxo- 2,3-dihydro-5H-hiazolo[3,2-a]pyrimidine-6-carboxarnide compounds.
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19.发明公开
公开(公告)号：EP3215510A4
公开(公告)日：2018-04-11
申请号：EP15856978
申请日：2015-11-06
IPC分类号： C07D487/04 , A61K31/519 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P43/00 , C07D519/00
CPC分类号： A61K31/519 , A61K31/13 , A61K31/16 , A61K2300/00 , C07D487/04 , C07D519/00
摘要： The invention provides substituted imidazo┌1,5-a┐pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,5-a]pyrimidine compounds described herein include substituted 2,4-dimethyl-N-phenylimidazo[1,5-a]pyrimidine-8-carbox-amide compounds and variants thereof.
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