公开(公告)号：EP4436562A1

公开(公告)日：2024-10-02

申请号：EP22823340.9

申请日：2022-11-25

申请人： OMEICOS Therapeutics GmbH

发明人： FISCHER, Robert ,  KONKEL, Anne ,  LOSSIE, Janine ,  INABA, Taro ,  SCHUNCK, Wolf-Hagen

IPC分类号： A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61K31/22 ,  A61K31/341 ,  A61K31/35 ,  A61K31/40 ,  A61K31/41 ,  A61K31/421 ,  A61K31/5375 ,  A61P3/10 ,  A61P9/04 ,  A61P9/06

CPC分类号： A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61K31/22 ,  A61K31/41 ,  A61K31/341 ,  A61K31/421 ,  A61K31/35 ,  A61K31/40 ,  A61K31/5375 ,  A61P9/04 ,  A61P9/06 ,  A61P3/10

公开(公告)号：EP4398888A1

公开(公告)日：2024-07-17

申请号：EP22778154.9

申请日：2022-09-07

申请人： Plakous Therapeutics, Inc.

发明人： WASHBURN, Scott, A. ,  TOMBLYN, Seth

IPC分类号： A61K31/00 ,  A61K35/00 ,  A61P25/00 ,  A61P27/02 ,  A61K38/57 ,  A61P19/02

CPC分类号： A61K35/50 ,  A61P25/00 ,  A61P27/02 ,  A61K38/57 ,  A61P19/02 ,  A61K31/137 ,  A61K31/16 ,  C12N2502/02520130101 ,  C12N5/0622

公开(公告)号：EP4272743A3

公开(公告)日：2024-07-10

申请号：EP23177574.3

申请日：2012-09-19

申请人： Allergan, Inc.

发明人： Abad, Jaun Carlos

IPC分类号： A61K31/27 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/4178 ,  A61K31/5415 ,  A61K45/06 ,  A61P27/02 ,  A61P27/06 ,  A61P27/10 ,  A61K31/4025 ,  A61K31/415

CPC分类号： A61K45/06 ,  A61K9/0048 ,  A61K31/27 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/325 ,  A61K31/4178 ,  A61K31/5415 ,  A61K31/16 ,  A61K31/541 ,  A61P27/02 ,  A61P27/06 ,  A61P27/10

摘要： The present invention is directed to compositions and methods for treating ocular conditions, including presbyopia, mild hyperopia, irregular astigmatism, hyperopic accommodative esotropia, and glaucoma. The compositions can also be used to potentiate or enhance interventions that retard, reverse, or modify the aging process of the crystalline lens and its surrounding tissues. The compositions include a cholinergic agent, such as a muscarinic acetylcholine receptor M3 agonist, and an alpha agonist having an imidazoline group or a non-steroidal anti-inflammatory agent (NSAID) having COX-2 selectivity. It has been found that an alpha agonist having an imidazoline group or non-steroidal anti-inflammatory agent (NSAID) having COX-2 selectivity in combination with a cholinergic agent, such as pilocarpine, act synergistically to improve the accommodative and focusing ability of the eye while minimizing the side effects from each compound.

公开(公告)号：EP3406246A2

公开(公告)日：2018-11-28

申请号：EP18173735.4

申请日：2013-09-10

申请人： Board of Regents of the Nevada System of Higher Education, on Behalf of the University of Nevada, Reno

发明人： BURKIN, Dean ,  WUEBBLES, Ryan

IPC分类号： A61K31/404 ,  A61K45/06 ,  A61K31/541 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/496 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4365 ,  A61K31/42 ,  A61P21/00 ,  A61P21/04

CPC分类号： A61K31/404 ,  A61K31/16 ,  A61K31/19 ,  A61K31/20 ,  A61K31/277 ,  A61K31/341 ,  A61K31/343 ,  A61K31/36 ,  A61K31/37 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4035 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4365 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/473 ,  A61K31/496 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/53 ,  A61K31/5365 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/541 ,  A61K31/551 ,  A61K31/57 ,  A61K31/575 ,  A61K31/661 ,  A61K38/05 ,  A61K38/39 ,  A61K45/06

摘要： Disclosed herein are α7β1 integrin modulatory agents and methods of using such to treat conditions associated with decreased α7β1 integrin expression or activity, including muscular dystrophy. In one example, methods for treating a subject with muscular dystrophy are disclosed. The methods include administering an effective amount of an α7β1 integrin modulatory agent to the subject with muscular dystrophy, wherein the α7β1 integrin modulatory agent increases α7β1 integrin expression or activity as compared to α7β1 integrin expression or activity prior to treatment, thereby treating the subject with muscular dystrophy. Also disclosed are methods of enhancing muscle regeneration, repair, or maintenance in a subject and methods of enhancing α7β1 integrin expression by use of the disclosed α7β1 integrin modulatory agents. Methods of prospectively preventing or reducing muscle injury or damage in a subject are also disclosed.

公开(公告)号：EP2858634B1

公开(公告)日：2018-10-03

申请号：EP13804151.2

申请日：2013-06-06

申请人： Olatec Therapeutics LLC

发明人： ST. LAURENT, Joseph P. ,  JONES, Gerald S. ,  BRESSE, David M.

IPC分类号： A61K31/10 ,  A61K31/095 ,  A61K9/20 ,  A61K9/48 ,  A61P29/00 ,  A61P25/00 ,  A61K9/00 ,  A61K47/08 ,  A61K47/14 ,  A61K9/06 ,  A61K31/145 ,  A61K31/16

CPC分类号： A61K31/16 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/06 ,  A61K31/145 ,  A61K47/08 ,  A61K47/14 ,  A61K47/18 ,  A61K47/32

摘要： The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and ω-(methylsulfonyl)alkylamine or ω-(methylsulfonyl)alkylamide. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering ω-(methylsulfonyl)alkylamine or ω-(methylsulfonyl)alkylamide, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.

公开(公告)号：EP3364948A1

公开(公告)日：2018-08-29

申请号：EP16787385.0

申请日：2016-10-20

申请人： TETEC Tissue Engineering Technologies AG

发明人： WURST, Helmut ,  GAISSMAIER, Christoph ,  CLAUSEN, Nils

IPC分类号： A61K9/08 ,  A61K47/42 ,  A61P19/02

CPC分类号： A61K47/6903 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/16 ,  A61K31/40 ,  A61K31/728 ,  A61K38/385 ,  A61K47/10 ,  A61K47/42 ,  A61K2300/00 ,  A61P19/02

摘要： The invention relates to medical compositions, a medical hydrogel, a medical kit, and a multi-chamber discharge device for use in the prevention and/or treatment of a disease of the facet joints and/or in the replacement and/or regeneration of facet joint cartilage.

公开(公告)号：EP3357493A1

公开(公告)日：2018-08-08

申请号：EP16851937.9

申请日：2016-09-30

申请人： Tohoku University

发明人： NAKAZAWA, Toru ,  AKAIKE, Takaaki ,  KUNIKATA, Hiroshi

IPC分类号： A61K31/195 ,  A61K31/198 ,  A61K38/00 ,  A61P27/02 ,  A61P39/06

CPC分类号： A61K31/16 ,  A61K31/195 ,  A61K31/198 ,  A61K31/4162 ,  A61K38/00 ,  A61P27/02

摘要： The present invention addresses the problem of providing an intraocular irrigating solution that allows the intraocular tissue to be sufficiently protected during ophthalmic surgery and further has high safety. The problem is solved by an intraocular irrigating solution containing at least one of active sulfur molecules of which examples include cysteine persulfide and glutathione persulfide.

公开(公告)号：EP3215124A4

公开(公告)日：2018-07-11

申请号：EP15857120

申请日：2015-11-05

申请人： NORDQUIST ROBERT E ,  ROSACKER JAMES A ,  DOWNES PATRICK J ,  CHEN WEI R

发明人： NORDQUIST ROBERT E ,  ROSACKER JAMES A ,  DOWNES PATRICK J ,  CHEN WEI R

IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K31/00 ,  A61K31/10 ,  A61K31/167 ,  A61K31/407 ,  A61K31/445 ,  A61K31/506 ,  A61K31/519 ,  A61K31/60 ,  A61K47/10 ,  A61K47/20 ,  A61K47/36

CPC分类号： A61K47/36 ,  A61K9/0014 ,  A61K9/0034 ,  A61K9/06 ,  A61K31/045 ,  A61K31/10 ,  A61K31/16 ,  A61K31/167 ,  A61K31/192 ,  A61K31/407 ,  A61K31/445 ,  A61K31/451 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/60 ,  A61K31/722 ,  A61K45/06 ,  A61K47/10 ,  A61K47/20 ,  A61K2300/00

摘要： Transdermal compositions including chitosan, glycated chitosan, or a combination thereof are provided for use in treatment methods wherein the compositions are externally applied for relieving pain and inflammation, treating erectile dysfunction, treating acne, causing hair growth, and for veterinary treatment of animals for relieving pain and inflammation.

公开(公告)号：EP3331610A1

公开(公告)日：2018-06-13

申请号：EP16739411.3

申请日：2016-07-06

申请人： Ruprecht-Karls-Universität Heidelberg ,  Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： OSSWALD, Matthias ,  WICK,Wolfgang ,  WINKLER, Frank ,  JUNG, Erik ,  BLAES, Jonas

IPC分类号： A61P35/00 ,  C12N15/113 ,  A61K31/155 ,  A61K31/495 ,  A61K31/4985 ,  A61K31/522 ,  A61K31/713

CPC分类号： A61K39/39558 ,  A61K31/13 ,  A61K31/155 ,  A61K31/16 ,  A61K31/495 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/515 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/7105 ,  A61K31/713 ,  A61K2300/00 ,  A61P35/00 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2330/50

摘要： The present invention relates to agents for use in the treatment of glioma, in particular astrocytoma WHO IF and 111°, as well as IV0 (glioblastoma), in a subject.

公开(公告)号：EP3230259A4

公开(公告)日：2018-05-23

申请号：EP15867510

申请日：2015-12-07

申请人： UNIV NEW YORK STATE RES FOUND

发明人： DEL POETA MAURIZIO ,  MOR VISESATO

IPC分类号： C07C251/86 ,  A61K31/15 ,  A61K31/16 ,  A61K31/7048 ,  A61K31/7072 ,  A61K38/12 ,  A61P31/10

CPC分类号： C07C251/86 ,  A01N37/28 ,  A61K31/16 ,  A61K31/4196 ,  A61K31/7048 ,  A61K31/7072 ,  A61K38/12 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides a compound having the structure: (I).