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11.发明公开METHODS AND COMPOSITIONS FOR INCREASING THE EFFICIENCY OF THERAPEUTIC ANTIBODIES USING ALLOREACTIVE NATURAL KILLER CELLS 审中-公开方法和组合物增加了治疗抗体的效率同种异体自然杀伤细胞
公开(公告)号：EP1648508A1
公开(公告)日：2006-04-26
申请号：EP04769123.3
申请日：2004-07-23
发明人： VELARDI, Andrea
IPC分类号： A61K39/395
CPC分类号： A61K35/17 , A61K2039/505 , C07K16/2887 , C07K2317/24 , C12N5/0646
摘要： The present invention relates, generally, to methods and compositions for increasing the efficiency of therapeutic antibodies. Their efficiency is enhanced through the increase of the ADCC mechanism. More particularly, the invention relates to the use of a therapeutic antibody in combination with alloreactive natural killer cells in order to enhance the efficiency of the treatment with therapeutic antibody in human subjects.
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12.发明公开GALACTOSAMINOGALACTAN COMPRISING 1-4 LINKED GALACTOSE AND 1-4 LINKED N-ACETYLGALACTOSAMINE FOR USE IN THE TREATMENT OF AT LEAST ONE INFLAMMATORY DISEASE 审中-公开GALACTOSAMINOGALACTAN 1-4个联网的半乳糖和交联的1-4 N-乙酰FOR USE IN至少一种抗疾病的治疗
公开(公告)号：EP2945638A1
公开(公告)日：2015-11-25
申请号：EP14700421.2
申请日：2014-01-14
发明人： LATGE, Jean-Paul , FONTAINE, Thierry Vincent Gérard , VAN DE VEERDONK, Frank Leo , GRESNIGT, Mark Sebastiaan , NETEA, Mihai , JOOSTEN, Leo AB , ROMANI, Luigina , BOZZA, Silvia , DE LUCA, Antonella
IPC分类号： A61K31/715 , A61K31/726 , A61P37/00 , A61P1/00
CPC分类号： A61K31/715 , A61K31/726 , A61K45/06
摘要： A first object of the invention is galactosaminogalactan comprising α1-4 linked galactose, α1-4 linked N-acetylgalactosamine, and optionally α1-4 linked galactosamine, for use in the treatment of at least one inflammatory disease. Another object of the invention is a pharmaceutical composition comprising a galactosaminogalactan comprising α1-4 linked galactose, α1-4 linked N-acetylgalactosamine, and optionally α1-4 linked galactosamine, as defined herein, and optionally a pharmaceutically acceptable carrier. Another object of the invention is a pharmaceutical composition according to the invention, for use in the treatment of at least one inflammatory disease. Another object of the invention is an inhibitor of IL-1RA for use in the treatment of human fungal diseases. Another object of the invention is a pharmaceutical composition comprising an inhibitor of IL-1RA, and optionally a pharmaceutically acceptable carrier.
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13.发明授权System for coding, decoding and wireless transmission of sensor data 有权系统，用于编码，解码和传感器数据的传输drähtlosen
公开(公告)号：EP2660755B1
公开(公告)日：2015-06-03
申请号：EP13161946.2
申请日：2013-04-02
发明人： Alimenti, Federico , Roselli, Luca
IPC分类号： G06K19/07
CPC分类号： G06K19/0716 , G06K19/0723
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公开(公告)号：EP2591367B1
公开(公告)日：2015-02-25
申请号：EP11738258.0
申请日：2011-07-06
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2835
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公开(公告)号：EP2591367A1
公开(公告)日：2013-05-15
申请号：EP11738258.0
申请日：2011-07-06
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2835
摘要： The present invention relates to method of identifying whether or not an individual has Parkinson's disease (PD). In particular, the invention relates to a method for identifying whether or not an individual has PD as opposed to another neurodegenerative disease. The method of the invention comprises measuring the concentration of a-synuclein (α-syn) and the concentration of unphosphorylated tau (tau) and/or phosphorylated tau (p-tau) in a cerebrospinal fluid sample taken from an individual. The method also comprises calculating the ratio of the concentration of tau and/or p-tau to the concentration of α-syn, and thereby determining whether or not the individual has PD.
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16.发明公开Methods and compositions for increasing the efficiency of therapeutic antibodies using NK cell potentiating compounds 审中-公开方法和组合物用于提高使用的化合物的治疗性抗体的效力即加强NK细胞
公开(公告)号：EP2292264A3
公开(公告)日：2012-12-19
申请号：EP10189264.4
申请日：2004-07-23
发明人： Velardi, Andrea , Romagne, François
IPC分类号： A61K39/395 , G01N33/50 , C07K16/28 , C12N5/0783
CPC分类号： C07K16/2803 , A61K2035/124 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K2317/732 , C07K2317/76 , C12N5/0646 , G01N33/5047 , G01N2333/70535 , G01N2500/10
摘要： The present invention relates, generally, to methods and compositions for increasing the efficiency of therapeutic antibodies. Their efficiency is enhanced through the increase of the ADCC mechanism. More particularly, the invention relates to the use of a therapeutic antibody in combination with compounds that block an inhibitory receptor or stimulate an activating receptor of an NK cell in order to enhance the efficiency of the treatment with therapeutic antibodies in human subjects.
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17.发明公开
公开(公告)号：EP2373299A2
公开(公告)日：2011-10-12
申请号：EP09807677.1
申请日：2009-12-18
发明人： CALAFIORE, Riccardo , LUCA, Giovanni , CALVITTI, Mario , BECCHETTI, Ennio , PUCCETTI, Paolo , FALLARINO, Francesca , NASTRUZZI, Claudio
CPC分类号： A61J3/07 , A61K9/5036 , A61K9/5089 , A61K35/48
摘要： The invention relates to the use of Sertoli cells (SC) microencapsulated into hydrogel-based microcapsules, for the prevention and/or treatment of Type 1 diabetes mellitus (T1DM) and to a process for producing microcapsules, preferably shaped as microspheres.
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18.发明公开Methods and compositions for increasing the efficiency of therapeutic antibodies using NK cell potentiating compounds 审中-公开方法和组合物用于提高使用的化合物的治疗性抗体的效力即加强NK细胞
公开(公告)号：EP2292264A2
公开(公告)日：2011-03-09
申请号：EP10189264.4
申请日：2004-07-23
发明人： Velardi, Andrea , Romagne, François
IPC分类号： A61K39/395 , G01N33/50
CPC分类号： C07K16/2803 , A61K2035/124 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K2317/732 , C07K2317/76 , C12N5/0646 , G01N33/5047 , G01N2333/70535 , G01N2500/10
摘要： The present invention relates, generally, to methods and compositions for increasing the efficiency of therapeutic antibodies. Their efficiency is enhanced through the increase of the ADCC mechanism. More particularly, the invention relates to the use of a therapeutic antibody in combination with compounds that block an inhibitory receptor or stimulate an activating receptor of an NK cell in order to enhance the efficiency of the treatment with therapeutic antibodies in human subjects.
摘要翻译： 本发明涉及，基因反弹，用于增加治疗性抗体的效率的方法和组合物。 他们的效率是通过ADCC机制的增加而增强。 更具体地，本发明涉及联合使用的治疗性抗体与化合物确实抑制性受体的块或刺激，以便增强与在人受试者中的治疗性抗体治疗的效率激活NK细胞的受体。
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