公开(公告)号：EP2998313B1

公开(公告)日：2018-10-10

申请号：EP13884437.8

申请日：2013-10-25

申请人： Caregen Co., Ltd.

发明人： CHUNG, Yong Ji ,  KIM, Eun Mi ,  LEE, Eung-Ji ,  LEE, Tae-Hoon ,  LEE, Young-Min

IPC分类号： A61P37/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61P37/00 ,  C07K14/70521 ,  G01N33/5023 ,  G01N2333/4703 ,  G01N2333/70535 ,  G01N2500/02 ,  G01N2500/10

摘要： A peptide according to the present invention can perform a function identical or similar to the function of natural CTLA-4 and has an excellent degree of skin penetration due to a small size. The peptide according to the present invention effectively binds to antigen presenting cell surface proteins (CD80 and CD86) to inhibit activity of T cells and thus is capable of inhibiting the expression of inflammatory cytokines (for example, IL-2 and IFN-³). As a result, a composition comprising the peptide according to the present invention exhibits excellent effects in terms of preventing, treating, or improving Th1-mediated immune diseases. Therefore, the superior activity and stability of the peptide according to the present invention can be useful when applied to medicine, quasi-drugs, and cosmetics.

公开(公告)号：EP3137504A4

公开(公告)日：2018-02-28

申请号：EP15785500

申请日：2015-04-30

申请人： HANALL BIOPHARMA CO LTD

发明人： KIM SUNG WUK ,  PARK SEUNG KOOK ,  JEONG JAE KAP ,  AHN HYEA KYUNG ,  KIM MIN SUN ,  KIM EUN SUN ,  YONG HAE-YOUNG ,  SHIN DONGOK ,  SONG YEON JUNG ,  YOO TAE HYOUNG

IPC分类号： C07K16/46 ,  A61K39/395 ,  A61P37/00 ,  C07K16/18 ,  C12N15/13 ,  C12N15/63 ,  G01N33/53

CPC分类号： C07K16/283 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/564 ,  G01N33/566 ,  G01N33/6854 ,  G01N2333/70535

摘要： The present disclosure relates to an isolated anti-FcRn antibody, which is an antibody binding to FcRn (stands for neonatal Fc receptor, also called FcRP, FcRB or Brambell receptor) that is a receptor with a high affinity for IgG or a fragment thereof, a method of preparing thereof, a composition for treating autoimmune disease, which comprises the antibody, and a method of treating and diagnosing autoimmune diseases using the antibody. The FcRn-specific antibody according to the present disclosure binds to FcRn non-competitively with IgG to reduce serum pathogenic auto-antibody levels, and thus can be used for the treatment of autoimmune diseases.

公开(公告)号：EP2662691B1

公开(公告)日：2017-10-11

申请号：EP13164630.9

申请日：2013-04-22

申请人： University Clinic of Respiratory and Allergic Diseases Golnik

发明人： Korosec, Peter ,  Kosnik, Mitja ,  Silar, Mira

IPC分类号： G01N33/50 ,  G01N33/68

CPC分类号： G01N33/5094 ,  G01N33/6893 ,  G01N2333/70535 ,  G01N2800/24

公开(公告)号：EP3010938A4

公开(公告)日：2017-08-09

申请号：EP14813232

申请日：2014-06-20

申请人： HANALL BIOPHARMA CO LTD

发明人： KIM SUNG WUK ,  PARK SEUNG KOOK ,  JEONG JAE KAP ,  KIM MIN SUN ,  KIM EUN SUN ,  HEO JEONG HAING ,  SONG YEON JUNG ,  YONG HAE-YOUNG ,  SHIN DONGOK

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K49/00 ,  A61P37/00 ,  C07K14/705 ,  C12N15/13 ,  G01N33/566

CPC分类号： C07K14/705 ,  A61K49/0004 ,  C07K16/283 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/566 ,  G01N2333/70535

公开(公告)号：EP2998313A4

公开(公告)日：2016-12-21

申请号：EP13884437

申请日：2013-10-25

申请人： CAREGEN CO LTD

发明人： CHUNG YOUNG JI ,  KIM EUN MI ,  LEE EUNG-JI ,  LEE TAE-HOON ,  LEE YOUNG-MIN

IPC分类号： C07K7/08 ,  A61K38/10 ,  A61P37/08

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K14/70521 ,  G01N33/5023 ,  G01N2333/4703 ,  G01N2333/70535 ,  G01N2500/02 ,  G01N2500/10

摘要： A peptide according to the present invention can perform a function identical or similar to the function of natural CTLA-4 and has an excellent degree of skin penetration due to a small size. The peptide according to the present invention effectively binds to antigen presenting cell surface proteins (CD80 and CD86) to inhibit activity of T cells and thus is capable of inhibiting the expression of inflammatory cytokines (for example, IL-2 and IFN-³). As a result, a composition comprising the peptide according to the present invention exhibits excellent effects in terms of preventing, treating, or improving Th1-mediated immune diseases. Therefore, the superior activity and stability of the peptide according to the present invention can be useful when applied to medicine, quasi-drugs, and cosmetics.

公开(公告)号：EP3030251A1

公开(公告)日：2016-06-15

申请号：EP14752766.7

申请日：2014-08-08

申请人： Onyx Therapeutics, Inc.

发明人： TUCH, Brian ,  DEGENHARDT, Jeremiah ,  LOEHR, Andrea ,  KWEI, Kevin ,  KIRK, Christopher, J.

IPC分类号： A61K38/05 ,  A61K38/07 ,  A61K31/145 ,  A61P35/02 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  A61K31/145 ,  A61K31/69 ,  A61K38/05 ,  A61K38/07 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2333/70535

摘要： Methods of treating a tumor in a subject and methods of determining a treatment regimen for a subject with a tumor are provided herein. In exemplary aspects, the methods comprise measuring the level of expression of immunoglobulin, FCGR2B, a gene listed in Table 4, or a combination thereof. In exemplary aspects, the subject is a subject from which a sample was obtained, wherein the level of immunoglobulin, FCGR2B, a gene listed in Table 4, or a combination thereof, has been measured from the sample. Related kits, computer readable-storage media, systems, and methods implemented by a processor in a computer are further provided.

摘要翻译： 本文提供了治疗受试者肿瘤的方法和确定肿瘤受试者的治疗方案的方法。 在示例性方面，所述方法包括测量免疫球蛋白，FCGR2B，表4所列基因或其组合的表达水平。 在示例性方面，受试者是从样品中测量样品的受试者，其中免疫球蛋白的水平，FCGR2B，表4中列出的基因或其组合。 还提供了由计算机中的处理器实现的相关工具包，计算机可读存储介质，系统和方法。

公开(公告)号：EP2917731A4

公开(公告)日：2016-06-01

申请号：EP13854034

申请日：2013-11-08

申请人： MACFARLANE BURNET INST FOR MEDICAL RES & PUBLIC HEALTH LTD

发明人： ANDERSON DAVID ANDREW ,  GARCIA MARY LOUISE ,  BARNES NADINE CARMEL ,  HANAFIAH KHAYRIYYAH MOHD ,  LANDAY ALAN LEE

IPC分类号： G01N33/53 ,  C12N15/12

CPC分类号： C07K14/70503 ,  C07K2319/00 ,  G01N33/56983 ,  G01N33/6854 ,  G01N2333/08 ,  G01N2333/10 ,  G01N2333/16 ,  G01N2333/70535 ,  G01N2469/20 ,  G01N2800/06

摘要： The specification describes an antibody capture process comprising (i) obtaining a biological sample comprising antibodies, (ii) contacting the biological sample with recombinant pIgR or a dIgA-binding variant, wherein the pIgR or variant binds dIgA and forms a pIgR-dIgA complex. The process may further comprise (iii) directly or indirectly assessing the level of the pIgR-dIgA complex or the level of a complex between pIgR-dIgA and an antigen of interest. There is also an antibody capture process for determining gut wall integrity in a test subject, wherein the level or ratio of SIgA to dIgA is compared to a corresponding level or ratio from a control subject. The specification provides kits embodying the process and recombinant pIgR when used for, or for use, in capturing or detecting dIgA and/or IgM.

摘要翻译： 本说明书描述了抗体捕获方法，其包括（i）获得包含抗体的生物样品，（ii）使生物样品与重组pIgR或dIgA结合变体接触，其中pIgR或变体结合dIgA并形成pIgR-dIgA复合物。 该方法可进一步包括（iii）直接或间接评估pIgR-dIgA复合物的水平或pIgR-dIgA与感兴趣的抗原之间的复合物的水平。 还有一种用于确定测试对象中的肠壁完整性的抗体捕获方法，其中将SIgA与dIgA的水平或比例与来自对照受试者的相应水平或比例进行比较。 本说明书提供了用于捕获或检测dIgA和/或IgM或用于捕获或检测dIgA和/或IgM的方法和实施该方法的重组pIgR的试剂盒。

公开(公告)号：EP2171444B1

公开(公告)日：2015-02-25

申请号：EP08781438.0

申请日：2008-07-07

申请人： Becton Dickinson and Company

发明人： GOLDBERG, Edward

IPC分类号： G01N33/50 ,  G01N33/569

CPC分类号： G01N33/5047 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/56972 ,  G01N2333/705 ,  G01N2333/70507 ,  G01N2333/7051 ,  G01N2333/70514 ,  G01N2333/70535 ,  G01N2333/70553 ,  G01N2333/70589 ,  G01N2333/70596

公开(公告)号：EP2158220A1

公开(公告)日：2010-03-03

申请号：EP08756842.4

申请日：2008-06-26

申请人： F-Star Biotechnologische Forschungs - Und Entwicklungsges. M.B.H.

发明人： HIMMLER, Gottfried ,  RÜKER, Florian ,  WOZNIAK-KNOPP, Gordana ,  MUDDE, Geert ,  REDL, Gerda

IPC分类号： C07K16/00 ,  C40B40/10 ,  C40B40/02

CPC分类号： C07K16/005 ,  C07K16/32 ,  C07K2317/52 ,  C07K2317/569 ,  C07K2318/10 ,  C40B30/04 ,  G01N33/6857 ,  G01N2333/70535

摘要： The present invention relates to a method of preparing a genetic package displaying oligomers of modular antibody domains binding to a target and to a scaffold ligand as well as to vectors and libraries of genetic packages produced thereby. The invention further relates to methods of selecting suitable linker sequences for use in such oligomer display.

摘要翻译： 本发明涉及一种制备显示与靶标和支架配体结合的模块抗体结构域的寡聚体的遗传包装的方法，以及由此产生的遗传包装的载体和文库。 本发明还涉及选择用于这种低聚物显示的合适的接头序列的方法。

公开(公告)号：EP1836557A4

公开(公告)日：2009-01-21

申请号：EP05851842

申请日：2005-11-18

申请人： TRILLIUM DIAGNOSTICS LLC

发明人： DAVIS BRUCE H ,  BAGWELL C BRUCE ,  HUNSBERGER BENJAMIN

IPC分类号： G06F7/00 ,  G01N33/48 ,  G01N33/537

CPC分类号： G01N33/6872 ,  G01N33/537 ,  G01N33/56972 ,  G01N33/582 ,  G01N2333/70535 ,  G01N2333/70596 ,  G01N2496/05 ,  G01N2800/26

摘要： The invention relates a method of quantifying CD64 and CD 163 expression in leukocytes and, specifically to a kit for use with a flow cytometer including a suspension of quantitative fluorescent microbead standards, fluorescent labeled antibodies directed to CD64 and CD 163, and analytical software. The software is used to take information on the microbead suspension and fluorescent labeled antibodies from a flow cytometer and analyse data, smooth curves, calculate new parameters, provide quality control measures and notify of expiration of the assay system.