公开(公告)号：EP2560973B1

公开(公告)日：2016-11-16

申请号：EP10850401.0

申请日：2010-10-21

申请人： Abbvie Inc.

发明人： WANG, Ying ,  BREWER, Jason, T. ,  AKRITOPOULOU-ZANZE, Irini ,  DJURIC, Stevan, W. ,  POHLKI, Frauke ,  BRAJE, Wilfried ,  RELO, Ana-Lucia

IPC分类号： C07D487/04 ,  C07D498/04 ,  C07D471/04 ,  C07D471/14 ,  A61K31/4985 ,  A61K31/551 ,  A61K31/553 ,  A61P25/28 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D471/14 ,  C07D487/14 ,  C07D491/04 ,  C07D498/04 ,  Y02E60/321

摘要： The present application relates to 1,2,3,4)4a,5,6,7-octahydropyrazino[1,2- a ][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1)2- a ][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1 H- pyrido[3,4- d (][2]benzazepine, 1,2,3,4,4a,5,6,7- octahydropyrazino[1,2- a ][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7 H -pyrazino[1,2- a ][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1 H- pyrazino[2,1- d ][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2- d ]pyrido[3,2-6] [1,4]diazepine derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.