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公开(公告)号：EP3668504A1
公开(公告)日：2020-06-24
申请号：EP18846740.1
申请日：2018-08-15
发明人： BRADY, Patrick , BRAJE, Wilfried , DAI, Yujia , DOHERTY, George , GONG, Jane , JANTOS, Katja , JI, Cheng , JUDD, Andrew , KUNZER, Aaron , MASTRACCHIO, Anthony , RISI, Roberto , SONG, Xiaohong , SOUERS, Andrew , SULLIVAN, Gerard , TAO, Zhi-Fu , TESKE, Jesse , WANG, Xilu , WENDT, Michael , YU, Yiyun , ZHU, Guidong , PENNING, Thomas , LAI, Chunqiu , KLING, Andreas , POHLKI, Frauke , POTIN, Dominique , GUILLIER, Fabrice
IPC分类号： A61K31/395 , A61P35/00 , C07D515/22
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公开(公告)号：EP3668503A1
公开(公告)日：2020-06-24
申请号：EP18845893.9
申请日：2018-08-15
发明人： BRADY, Patrick , BRAJE, Wilfried , DAI, Yujia , DOHERTY, George , GONG, Jane , JANTOS, Katja , JI, Cheng , JUDD, Andrew , KUNZER, Aaron , MASTRACCHIO, Anthony , RISI, Roberto , SONG, Xiaohong , SOUERS, Andrew , SULLIVAN, Gerard , TAO, Zhi-fu , TESKE, Jesse , WANG, Xilu , WENDT, Michael , YU, Yiyun , ZHU, Guidong , PENNING, Thomas , LAI, Chunqiu
IPC分类号： A61K31/395 , A61P35/00 , C07D515/22
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公开(公告)号：EP3668502A1
公开(公告)日：2020-06-24
申请号：EP18845598.4
申请日：2018-08-15
申请人： AbbVie Inc. , Abbvie Deutschland GmbH & Co. KG , Braje, Wilfried , Doherty, George , Jantos, Katja , Ji, Cheng , Judd, Andrew , Kunzer, Aaron , Mastracchio, Anthony , Song, Xiaohong , Souers, Andrew , Sullivan, Gerard , Tao, Zhi-Fu , Lai, Chunqiu , Kling, Andreas , Pohlki, Frauke , Teske, Jesse , Wendt, Michael , Brady, Patrick , Wang, Xilu , Penning, Thomas , Michaelides, Michael
发明人： BRAJE, Wilfried , DOHERTY, George , JANTOS, Katja , JI, Cheng , JUDD, Andrew , KUNZER, Aaron , MASTRACCHIO, Anthony , SONG, Xiaohong , SOUERS, Andrew , SULLIVAN, Gerard , TAO, Zhi-Fu , LAI, Chunqui , KLING, Andreas , POHLKI, Frauke , TESKE, Jessc , WENDT, Michael , BRADY, Patrick , WANG, Xilu , PENNING, Thomas , MICHAELIDES, Michael
IPC分类号： A61K31/395 , A61P35/00 , C07D515/22
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4.发明公开
公开(公告)号：EP3408258A1
公开(公告)日：2018-12-05
申请号：EP17701874.4
申请日：2017-01-27
发明人： BRAJE, Wilfried , BRITZE, Katarina , DIETRICH, Justin, D. , JOLIT, Anais , KASCHEL, Johannes , KLEE, Johanna , LINDNER, Tanja
IPC分类号： C07D215/227 , C07B37/04 , C07B43/04 , C07B43/06 , C07D405/04 , C07D239/26 , C07D409/04 , C07F5/02 , C07D307/36
CPC分类号： C07B63/04 , C07B37/04 , C07B43/04 , C07B43/06 , C07C41/46 , C07C67/62 , C07C209/90 , C07C213/10 , C07C231/22 , C07C253/32 , C07C269/08 , C07C273/189 , C07C303/42 , C07C319/26 , C07D205/04 , C07D207/34 , C07D209/08 , C07D209/48 , C07D211/06 , C07D213/74 , C07D215/227 , C07D239/26 , C07D239/42 , C07D307/36 , C07D307/81 , C07D311/58 , C07D405/04 , C07D409/04 , C07D471/04 , C07D495/04 , C07F5/02 , C07F5/025
摘要： The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.
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5.发明公开
公开(公告)号：EP2895485A1
公开(公告)日：2015-07-22
申请号：EP13762483.9
申请日：2013-09-13
发明人： KOOLMAN, Hannes , BRAJE, Wilfried , MACK, Helmut , HAUPT, Andreas , RELO, Ana Lucia , DRESCHER, Karla , BAKKER, Margaretha Henrica Maria , LAKICS, Viktor , HOFT, Carolin , XU, Ruxu , ZHAO, Xiaona
IPC分类号： C07D471/06 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06 , C07D487/16
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
摘要翻译： 本发明涉及三环喹啉和喹喔啉衍生物，涉及含有这些化合物的药物组合物，其用作5-HT 2C受体的调节剂，特别是激动剂或部分激动剂，其用于制备预防或治疗 对5-HT 2C受体的调节作出反应的病症和障碍，以及用于预防或治疗对5-HT 2C受体调节作用的病症和障碍的方法。
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公开(公告)号：EP2571353A1
公开(公告)日：2013-03-27
申请号：EP10851903.4
申请日：2010-11-19
申请人： AbbVie Inc. , Abbott GmbH & Co. KG
发明人： AKRITOPOULOU-ZANZE, Irini , BRAJE, Wilfried , DJURIC, Stevan W. , WILSON, Noel S. , TURNER, Sean C. , KRUGER, Albert W. , RELO, Ana-Lucia , SHEKHAR, Shashank , WELCH, Dennie S. , ZHAO, Hongyu , GANDARILLA, Jorge , GASIECKI, Alan F. , LI, Huanqiu , THOMPSON, Christina M. , ZHANG, Min
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译： 本申请涉及芳基 - 和杂芳基稠合的decahydropyrroloazepine，octahydrooxepinopyrrole，octahydropyrrolothiazepine氧化钛，decahydrocyclohepta并[c]吡咯，和三烯并[c]吡咯的式（I）worin R1，R2，R3，R4，R5，A，Y1的衍生物 ，Y2，Y3和如说明书中所定义。 因此，本申请涉及组合物，包含测试的化合物，用于鉴定受试化合物处理用于制造检验化合物，以及一种使用测试化合物和组合物的疾病病症的方法，与方法。
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公开(公告)号：EP3988555A1
公开(公告)日：2022-04-27
申请号：EP21197248.4
申请日：2018-08-15
发明人： BRAJE, Wilfried , DOHERTY, George , JANTOS, Katja , JI, Cheng , JUDD, Andrew , KUNZER, Aaron , MASTRACCHIO, Anthony , SONG, Xiaohong , SOUERS, Andrew , SULLIVAN, Gerard , TAO, Zhi-Fu , TESKE, Jesse , WANG, Xilu , WENDT, Michael , PENNING, Thomas , LAI, Chunqiu , KLING, Andreas , POHKLI, Frauke
IPC分类号： C07D515/22 , A61K31/395 , A61P35/00
摘要： The present disclosure provides for compounds of formula (I)
wherein A 2 , A 3 , A 4 , A 6 , A 7 , A 8 , A 15 , R A , R 5 , R 9 , R 10A , R 10B , R 11 , R 12 , R 13 , R 14 , R 16 , W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).-
8.发明公开
公开(公告)号：EP3601255A1
公开(公告)日：2020-02-05
申请号：EP18716451.2
申请日：2018-03-20
发明人： BACKFISCH, Gisela , BAKKER, Margaretha , BLACK, Lawrence , BRAJE, Wilfried , DRESCHER, Karla , ERHARD, Thomas , HAUPT, Andreas , HOFT, Carolin , KLING, Andreas , LAKICS, Viktor , MACK, Helmut , RELO, Ana Lucia , OELLIEN, Frank
IPC分类号： C07D401/12 , C07D405/12 , C07D207/16 , A61P25/24 , A61P25/14 , A61P9/00 , A61P25/22 , A61P25/28 , A61P25/18 , A61P25/30 , A61P3/10 , A61K31/40
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9.发明授权HETEROCYCLIC COMPOUNDS AS POSITIVE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 (MGLU2 RECEPTOR) 有权杂环化合物代谢型谷氨酸受体2（的mGlu2 PRS）作为正调节剂
公开(公告)号：EP2167464B1
公开(公告)日：2014-12-03
申请号：EP08759978.3
申请日：2008-05-23
发明人： GENESTE, Hervé , SAUER, Daryl , BRAJE, Wilfried , AMBERG, Wilhelm , MEZLER, Mario , BAKKER, Margaretha Henrica Maria
IPC分类号： C07D209/26 , C07D231/12 , C07D333/58 , C07D239/26 , C07D277/28 , C07D233/58 , C07D409/04 , C07D409/06 , C07D333/20 , C07D307/14 , C07D213/36 , C07D213/38
CPC分类号： C07D209/14 , C07D207/335 , C07D209/26 , C07D213/36 , C07D213/38 , C07D215/12 , C07D231/12 , C07D233/58 , C07D239/26 , C07D261/08 , C07D277/28 , C07D307/14 , C07D307/54 , C07D333/20 , C07D333/58 , C07D407/04 , C07D409/04 , C07D409/06
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公开(公告)号：EP2560973A1
公开(公告)日：2013-02-27
申请号：EP10850401.0
申请日：2010-10-21
申请人： Abbvie Inc.
发明人： WANG, Ying , BREWER, Jason, T. , AKRITOPOULOU-ZANZE, Irini , DJURIC, Stevan, W. , POHLKI, Frauke , BRAJE, Wilfried , RELO, Ana-Lucia
IPC分类号： C07D487/04 , C07D498/04 , C07D471/04 , C07D471/14 , A61K31/4985 , A61K31/551 , A61K31/553 , A61P25/28 , A61P3/04 , A61P3/10
CPC分类号： C07D487/04 , C07D471/04 , C07D471/14 , C07D487/14 , C07D491/04 , C07D498/04 , Y02E60/321
摘要： The present application relates to 1,2,3,4)4a,5,6,7-octahydropyrazino[1,2- a ][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1)2- a ][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1 H- pyrido[3,4- d (][2]benzazepine, 1,2,3,4,4a,5,6,7- octahydropyrazino[1,2- a ][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7 H -pyrazino[1,2- a ][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1 H- pyrazino[2,1- d ][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2- d ]pyrido[3,2-6] [1,4]diazepine derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , and Y 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
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